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SUV39H1 Antibody (711473) in WB
Western blot analysis was performed on Nuclear extracts (30 µg lysate) of HCT 116 (Lane 1), COS-7 (Lane 2), A-431 (Lane 3), HeLa (Lane 4), Hep G2 (Lane 5) and A549 (Lane 6). The blots were probed with Anti-SUV39H1 Recombinant Rabbit Superclonal™ Antibody (Product # 711473, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 48 kDa band corresponding to SUV39H1 was observed across the cell lines tested. Known qua... View More
Product Details
711473
Product Specifications
Species Reactivity
Cynomolgus monkey,
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
3HCLC
Immunogen
Protein corresponding to human SUV39H1 (aa65-214)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2662108
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Sheep
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 homolog 1 (Drosophila)
Gene Aliases: H3-K9-HMTase 1; KMT1A; MG44; SUV39H; SUV39H1
UniProt ID: (Human) O43463
Entrez Gene ID: (Cynomolgus monkey) 102134179, (Human) 6839
transcription regulatory region sequence-specific DNA binding
chromatin binding
protein binding
zinc ion binding
S-adenosylmethionine-dependent methyltransferase activity
histone-lysine N-methyltransferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K9 specific)
protein N-terminus binding
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin organization
transcription, DNA-templated
rRNA processing
cellular response to DNA damage stimulus
cell cycle
viral process
cell differentiation
histone H3-K9 dimethylation
histone H3-K9 trimethylation
negative regulation of circadian rhythm
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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