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Invitrogen
SUV420H2 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C409)
FIGURE: 1 / 2
SUV420H2 Chimeric Antibody (MA5-48341) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of SUV420H2 in HEK293 cells using SUV420H2 Chimeric Monoclonal Antibody (Product # MA5-48341). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with SUV420H2 Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining. The nuclear stain is DAPI (blue) and the actin ... View More
Product Details
MA5-48341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RAB-C409
Immunogen
This antibody was obtained by recombinant antibody (rAb) phage display recognizing SUV420H2 protein under non-denaturing conditions.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074783
Product Specific Information
Specificity: This antibody recognizes KMT5C (Histone-lysine N-methyltransferase KMT5C). It binds to a folded domain, amino acids 2-248. KMT5C is a histone methyltransferase that regulates transcription and maintenance of genome integrity.
Target Information
SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H4]-lysine20 N-methyltransferase KMT5B; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; Histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; lysine (K)-specific methyltransferase 5C; Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; Su(var)4-20 homolog 2; Suppressor of variegation 4-20 homolog 2; suv4-20h2
Gene Aliases: KMT5C; PP7130; SUV420H2
UniProt ID: (Human) Q86Y97
Entrez Gene ID: (Human) 84787
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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