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This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.
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Protein Aliases: Armadillo repeat-containing protein 10; specific splicing variant involved in hepatocarcinogenesis; Splicing variant involved in hepatocarcinogenesis protein; SVH protein
Gene Aliases: 2810037C14Rik; ARMC10; PNAS-112; PNAS112; PSEC0198; RGD1305915; SVH
UniProt ID: (Human) Q8N2F6, (Rat) B1WBW4, (Mouse) Q9D0L7
Entrez Gene ID: (Human) 83787, (Rat) 296758, (Mouse) 67211
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