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Abnova
SWAP70 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
SWAP70 Antibody (H00023075-D01P) in WB
Western Blot analysis of SWAP70 expression in transfected 293T cell line (H00023075-T02) by SWAP70 MaxPab polyclonal antibody.
Lane 1: SWAP70 transfected lysate(69.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SWAP70 transfected lysate(69.00 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00023075-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SWAP70 (NP_055870.2, 1 a.a. approximately 585 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGSLKEELLK AIWHAFTALD QDHSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD EGPVSNQGYM PYLNRFILEK VQDNFDKIEF NRMCWTLCVK KNLTKNPLLI TEEDAFKIWV IFNFLSEDKY PLIIVSEEIE YLLKKLTEAM GGGWQQEQFE HYKINFDDSK NGLSAWELIE LIGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMMKK GHRRKNWTER WFVLKPNIIS YYVSEDLKDK KGDILLDENC CVESLPDKDG KKCLFLVKCF DKTFEISASD KKKKQEWIQA IHSTIHLLKL GSPPPHKEAR QRRKELRKKQ LAEQEELERQ MKELQAANES KQQELEAVRK KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQAIQTTEA EKQELENQRV LKEQALQEAM EQLEQLELER KQALEQYEEV KKKLEMATNK TKSWKDKVAH HEGLIRLIEP GSKNPHLITN WGPAAFTEAE LEEREKNWKE KKTTE
Target Information
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ39540; KIAA0640 protein; SWAP-70; Switch-associated protein 70
Gene Aliases: HSPC321; KIAA0640; SWAP-70; SWAP70
UniProt ID: (Human) Q9UH65
Entrez Gene ID: (Human) 23075
positive regulation of cytosolic calcium ion concentration
negative regulation of actin filament depolymerization
positive regulation of actin filament bundle assembly
regulation of protein localization
negative regulation of cell-cell adhesion mediated by integrin
isotype switching
actin filament bundle assembly
positive regulation of mast cell chemotaxis
cell-cell adhesion
negative regulation of peptidyl-serine dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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