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Invitrogen
SYNPO2L Polyclonal Antibody
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SYNPO2L Antibody (PA5-96246) in WB
Western blot analysis of SYNPO2L in extracts of Mouse heart. Samples were incubated with SYNPO2L Polyclonal antibody (Product # PA5-96246) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-96246
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human SYNPO2L (NP_0011076051)
Conjugate
Form
Liquid
Concentration
0.03 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808048
Product Specific Information
Immunogen sequence: HVTPKTPPPM APKTPPPMTP KTPPPVAPKP PSRGLLDGLV NGAASSAGIP EPPRLQGRGG ELFAKRQSRA DRYVVEGTPG PGLGPRPRSP SPTPSLPPSW K; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, cytoskeleton
Target Information
SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Synaptopodin 2-like protein
Gene Aliases: 1110054M18Rik; Chap; Synpo2l
UniProt ID: (Mouse) Q8BWB1
Entrez Gene ID: (Mouse) 68760
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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