Proteintech

SYTL4 Polyclonal Antibody

SYTL4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SYTL4 Antibody (12128-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 12128-1-AP) (SYTL4 antibody) at dilution of 1:200 (under 10x lens).

SYTL4 Antibody in Immunoprecipitation (IP)

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Product Details

12128-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SYTL4 Fusion Protein Ag2772 (338-671 aa encoded by BC014913)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IGSMMSIYS EAGDFGNIFV TGRIAFSLKY EQQTQSLVVH VKECHQLAYA DEAKKRSNPY VKTYLLPDKS RQGKRKTSIK RDTVNPLYDE TLRYEIPESL LAQRTLQFSV WHHGRFGRNT FLGEAEIQMD SWKLDKKLDH CLPLHGKISA ESPTGLPSHK GELVVSLKYI PASKTPVGGD RKKSKGGEGG ELQVWIKEAK NLTAAKAGGT SDSFVKGYLL PMRNKASKRK TPVMKKTLNP HYNHTFVYNG VRLEDLQHMC LELTVWDREP LASNDFLGGV RLGVGTGISN GEVVDWMDST GEEVSLWQKM RQYPGSWAEG TLQLRSSMAK QKLGL (338-671 aa encoded by BC014913)

Target Information

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.

Theranostics

Liu XY,Jiang W,Ma D,Ge LP,Yang YS,Gou ZC,Xu XE,Shao ZM,Jiang YZ

Mon May 31 00:00:00 UTC 2021

SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.

Theranostics

Liu XY,Jiang W,Ma D,Ge LP,Yang YS,Gou ZC,Xu XE,Shao ZM,Jiang YZ

Mon May 31 00:00:00 UTC 2021

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Arteriosclerosis, thrombosis, and vascular biology

Adam F,Kauskot A,Kurowska M,Goudin N,Munoz I,Bordet JC,Huang JD,Bryckaert M,Fischer A,Borgel D,de Saint Basile G,Christophe OD,Ménasché G

Tue May 01 00:00:00 UTC 2018

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Arteriosclerosis, thrombosis, and vascular biology

Adam F,Kauskot A,Kurowska M,Goudin N,Munoz I,Bordet JC,Huang JD,Bryckaert M,Fischer A,Borgel D,de Saint Basile G,Christophe OD,Ménasché G

Tue May 01 00:00:00 UTC 2018

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Arteriosclerosis, thrombosis, and vascular biology

Adam F,Kauskot A,Kurowska M,Goudin N,Munoz I,Bordet JC,Huang JD,Bryckaert M,Fischer A,Borgel D,de Saint Basile G,Christophe OD,Ménasché G

Tue May 01 00:00:00 UTC 2018

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Arteriosclerosis, thrombosis, and vascular biology

Adam F,Kauskot A,Kurowska M,Goudin N,Munoz I,Bordet JC,Huang JD,Bryckaert M,Fischer A,Borgel D,de Saint Basile G,Christophe OD,Ménasché G

Tue May 01 00:00:00 UTC 2018

Proteomic analysis of insulin secretory granules in INS-1 cells by protein correlation profiling.

Biophysics reports

Li M,Du W,Zhou M,Zheng L,Song E,Hou J

Wed Mar 30 00:00:00 UTC 2022

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Nature communications

Takahashi A,Okada R,Nagao K,Kawamata Y,Hanyu A,Yoshimoto S,Takasugi M,Watanabe S,Kanemaki MT,Obuse C,Hara E

Tue May 16 00:00:00 UTC 2017

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Nature communications

Takahashi A,Okada R,Nagao K,Kawamata Y,Hanyu A,Yoshimoto S,Takasugi M,Watanabe S,Kanemaki MT,Obuse C,Hara E

Tue May 16 00:00:00 UTC 2017

Identification of tyrosine-phosphorylated proteins associated with lung cancer metastasis using label-free quantitative analyses.

Journal of proteome research

Wu HY,Tseng VS,Chen LC,Chang HY,Chuang IC,Tsay YG,Liao PC

Fri Aug 06 00:00:00 UTC 2010

Identification of tyrosine-phosphorylated proteins associated with lung cancer metastasis using label-free quantitative analyses.

Journal of proteome research

Wu HY,Tseng VS,Chen LC,Chang HY,Chuang IC,Tsay YG,Liao PC

Fri Aug 06 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Exophilin-2; Granuphilin; granuphilin b; granuphilin-a; granuphilin-b; synaptotagmin-like 4 (granuphilin-a); Synaptotagmin-like protein 4

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Gene Aliases: Gph; SLP4; SYTL4

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UniProt ID: (Human) Q96C24, (Mouse) Q9R0Q1, (Rat) Q8VHQ7

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Entrez Gene ID: (Human) 94121, (Mouse) 27359, (Rat) 140594

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Function(s)

calcium ion binding protein binding phospholipid binding calcium-dependent phospholipid binding Rab GTPase binding syntaxin binding clathrin binding neurexin family protein binding zinc ion binding metal ion binding

Process(es)

intracellular protein transport exocytosis synaptic vesicle exocytosis regulation of calcium ion-dependent exocytosis positive regulation of exocytosis negative regulation of insulin secretion calcium ion-regulated exocytosis of neurotransmitter positive regulation of protein secretion multivesicular body sorting pathway vesicle fusion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SYTL4 Polyclonal Antibody

SYTL4 Antibody (12128-1-AP) in IHC (P)

Product Details

12128-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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