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Invitrogen
Sarcomeric alpha Actin Monoclonal Antibody (5C5)
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Product Details
MA1-21597
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rabbit
Published species
Dog,
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
5C5
Immunogen
Purified rabbit striated muscle actin.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_557425
Product Specific Information
MA1-21597 detects alpha sarcomeric actin in bovine, guinea pig,human, rabbit, rat, fish, pig, snake, Xenopus and sheep samples.
Target Information
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: act; actg; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; actin, alpha, cardiac muscle 1; Actin, aortic smooth muscle; Alpha-actin-1; Alpha-actin-2; Alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; beta-actin; Cell growth-inhibiting gene 46 protein; cytoplasmic beta-actin; dfna20; dfna26; MGC75587; nemaline myopathy type 3
Gene Aliases: AAT6; ACTA; ACTA1; ACTA2; ACTC; ACTC1; ACTSA; ACTVS; ASD5; ASMA; CFTD; CFTD1; CFTDM; CMD1R; CMH11; GIG46; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; SHPM
UniProt ID: (Human) P68133, (Rabbit) P62740, (Human) P62736, (Human) P68032
Entrez Gene ID: (Human) 58, (Rabbit) 100009271, (Human) 59, (Human) 70, (Rabbit) 100340339, (Rabbit) 100009506
apoptotic process
positive regulation of gene expression
actin filament-based movement
muscle filament sliding
skeletal muscle thin filament assembly
actomyosin structure organization
actin-myosin filament sliding
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
mesenchyme migration
muscle contraction
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
cell growth
skeletal muscle fiber adaptation
response to steroid hormone
skeletal muscle fiber development
regulation of blood pressure
response to virus
vascular smooth muscle contraction
glomerular mesangial cell development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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