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Secretogranin II Polyclonal Antibody

Secretogranin II Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Secretogranin II Antibody (20357-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 20357-1-AP (Secretogranin II antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Secretogranin II Antibody in Western Blot (WB)

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Product Details

20357-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCG2 Fusion Protein Ag14215

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

233 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Exploration and validation of the influence of angiogenesis-related factors in aortic valve calcification.

Frontiers in cardiovascular medicine

Kong X,Meng L,Wei K,Lv X,Liu C,Lin F,Gu X

Sun Feb 26 00:00:00 UTC 2023

Exploration and validation of the influence of angiogenesis-related factors in aortic valve calcification.

Frontiers in cardiovascular medicine

Kong X,Meng L,Wei K,Lv X,Liu C,Lin F,Gu X

Sun Feb 26 00:00:00 UTC 2023

Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.

Cell reports

Wang T,Xu J,Xu Y,Xiao J,Bi N,Gu X,Wang HL

Tue Mar 08 00:00:00 UTC 2022

Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.

Frontiers in neurology

Feng J,Lin H,Zhao Y,Yang Y,Zhuang X,Yu Y,Yu Y

Tue Jan 03 00:00:00 UTC 2023

Maturation and circuit integration of transplanted human cortical organoids.

Nature

Revah O,Gore F,Kelley KW,Andersen J,Sakai N,Chen X,Li MY,Birey F,Yang X,Saw NL,Baker SW,Amin ND,Kulkarni S,Mudipalli R,Cui B,Nishino S,Grant GA,Knowles JK,Shamloo M,Huguenard JR,Deisseroth K,Pașca SP

Sat Oct 01 00:00:00 UTC 2022

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.

The Journal of cell biology

Xu H,Chang F,Jain S,Heller BA,Han X,Liu Y,Edwards RH

Mon May 02 00:00:00 UTC 2022

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.

The Journal of cell biology

Xu H,Chang F,Jain S,Heller BA,Han X,Liu Y,Edwards RH

Mon May 02 00:00:00 UTC 2022

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.

The Journal of cell biology

Xu H,Chang F,Jain S,Heller BA,Han X,Liu Y,Edwards RH

Mon May 02 00:00:00 UTC 2022

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.

The Journal of cell biology

Xu H,Chang F,Jain S,Heller BA,Han X,Liu Y,Edwards RH

Mon May 02 00:00:00 UTC 2022

Potential biomarkers and immune cell infiltration involved in aortic valve calcification identified through integrated bioinformatics analysis.

Frontiers in physiology

Lv X,Wang X,Liu J,Wang F,Sun M,Fan X,Ye Z,Liu P,Wen J

Tue Jan 03 00:00:00 UTC 2023

Tumor Microenvironment Heterogeneity-Based Score System Predicts Clinical Prognosis and Response to Immune Checkpoint Blockade in Multiple Colorectal Cancer Cohorts.

Frontiers in molecular biosciences

Wang H,Li Z,Ou S,Song Y,Luo K,Guan Z,Zhao L,Huang R,Yu S

Sat Jul 16 00:00:00 UTC 2022

Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.

Molecular oncology

Fang C,Dai L,Wang C,Fan C,Yu Y,Yang L,Deng H,Zhou Z

Wed Dec 01 00:00:00 UTC 2021

Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.

Molecular oncology

Fang C,Dai L,Wang C,Fan C,Yu Y,Yang L,Deng H,Zhou Z

Wed Dec 01 00:00:00 UTC 2021

Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.

Molecular oncology

Fang C,Dai L,Wang C,Fan C,Yu Y,Yang L,Deng H,Zhou Z

Wed Dec 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Chromogranin C (Secretogranin II); Chromogranin-C; secretogranin 2; Secretogranin II; secretogranin II (chromogranin C); Secretogranin-2; secretoneurin; SgII

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Gene Aliases: Chcg; CHGC; EM66; Scg-2; SCG2; SgII; SN

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UniProt ID: (Human) P13521, (Mouse) Q03517, (Rat) P10362

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Entrez Gene ID: (Human) 7857, (Mouse) 20254, (Rat) 24765

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Function(s)

cytokine activity protein binding chemoattractant activity

Process(es)

MAPK cascade angiogenesis positive regulation of endothelial cell proliferation intracellular signal transduction eosinophil chemotaxis positive chemotaxis induction of positive chemotaxis negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of endothelial cell proliferation inflammatory response protein secretion endothelial cell migration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Secretogranin II Polyclonal Antibody

Secretogranin II Antibody (20357-1-AP) in IHC (P)

Product Details

20357-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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