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Invitrogen
Serum Amyloid P Polyclonal Antibody
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FIGURE: 1 / 4
Serum Amyloid P Antibody (PA5-96028) in IHC (P)
Immunohistochemistry analysis of Serum Amyloid P in paraffin-embedded mouse liver. Samples were incubated with Serum Amyloid P Polyclonal antibody (Product # PA5-96028) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-223 of human APCS (NP_0016301)
Conjugate
Form
Liquid
Concentration
1.73 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807830
Product Specific Information
Positive Samples: 293T
Immunogen sequence: MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV
Target Information
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 9.5S alpha-1-glycoprotein; APCS amyloid P-component serum protein; epididymis secretory sperm binding protein Li 92n; MGC88159; Pentaxin related; pentaxin-related; Pentraxin 2; pentraxin-2; pentraxin-related; PTX 2; SAMP; SAP; Serum amyloid P-component
Gene Aliases: APCS; HEL-S-92n; PTX2; SAP
UniProt ID: (Human) P02743, (Mouse) P12246, (Rat) P23680
Entrez Gene ID: (Human) 325, (Mouse) 20219, (Rat) 29339
negative regulation of acute inflammatory response
protein folding
acute-phase response
cellular protein metabolic process
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
negative regulation of monocyte differentiation
negative regulation of viral entry into host cell
negative regulation of viral process
chaperone-mediated protein complex assembly
negative regulation of wound healing
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
protein complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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