Product References
SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet-Induced Obese Mice.
Antioxidants & redox signaling
Gao T,Wang J,Xiao M,Wang J,Wang S,Tang Y,Zhang J,Lu G,Guo H,Guo Y,Liu Q,Li J,Gu J
Mon Apr 01 00:00:00 UTC 2024
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
International journal of biological sciences
Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX
Thu Feb 09 00:00:00 UTC 2023
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
International journal of biological sciences
Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX
Thu Feb 09 00:00:00 UTC 2023
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
International journal of biological sciences
Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX
Thu Feb 09 00:00:00 UTC 2023
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
International journal of biological sciences
Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX
Thu Feb 09 00:00:00 UTC 2023
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Science translational medicine
Kartha N,Gianopulos JE,Schrank Z,Cavender SM,Dobersch S,Kynnap BD,Wallace-Povirk A,Wladyka CL,Santana JF,Kim JC,Yu A,Bridgwater CM,Fuchs K,Dysinger S,Lampano AE,Notta F,Price DH,Hsieh AC,Hingorani SR,Kugel S
Wed May 03 00:00:00 UTC 2023
Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression.
Molecular nutrition & food research
Wang G,Chen L,Qin S,Geng H,Xia C,Zheng Y,Lei X,Zhang J,Wu S,Yao J,Deng L
Wed Mar 01 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.
Archives of biochemistry and biophysics
Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D
Sat Jul 15 00:00:00 UTC 2023
Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.
The Journal of nutrition
Kanzaki K,Wada M
Tue Aug 01 00:00:00 UTC 2023
Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.
The Journal of nutrition
Kanzaki K,Wada M
Tue Aug 01 00:00:00 UTC 2023
NRF3 activates mTORC1 arginine-dependently for cancer cell viability.
iScience
Hirose S,Waku T,Tani M,Masuda H,Endo K,Ashitani S,Aketa I,Kitano H,Nakada S,Wada A,Hatanaka A,Osawa T,Soga T,Kobayashi A
Fri Feb 17 00:00:00 UTC 2023
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
EMBO molecular medicine
Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M
Mon Jul 10 00:00:00 UTC 2023
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.
Cell reports
Yin S,Liu L,Ball LE,Wang Y,Bedford MT,Duncan SA,Wang H,Gan W
Tue Apr 25 00:00:00 UTC 2023
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Molecular cell
Jiang C,Dai X,He S,Zhou H,Fang L,Guo J,Liu S,Zhang T,Pan W,Yu H,Fu T,Li D,Inuzuka H,Wang P,Xiao J,Wei W
Thu Jan 05 00:00:00 UTC 2023
Sestrin2 prevents neonatal incision pain and re-incision enhanced hyperalgesia in adult rats.
Brain research
Shi X,Wang C,Zhao T,Gu M,Yang J,Sun N,Huang Y,Yao Y,Yu L,Yan M
Sat Apr 15 00:00:00 UTC 2023
Sestrin2 prevents neonatal incision pain and re-incision enhanced hyperalgesia in adult rats.
Brain research
Shi X,Wang C,Zhao T,Gu M,Yang J,Sun N,Huang Y,Yao Y,Yu L,Yan M
Sat Apr 15 00:00:00 UTC 2023
Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3.
Cells
Iglesias M,Wang H,Krause-Hauch M,Ren D,Zoungrana LI,Li Z,Zhang J,Wei J,Yadav N,Patel K,Fatmi MK,Liu R,Lesnefsky EJ,Li J
Wed Mar 08 00:00:00 UTC 2023
SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells.
Cells
Güttler A,Weinholdt C,Ruff E,Reidt J,Darnstaedt E,Wildemann A,Petrenko M,Keßler J,Kappler M,Grosse I,Vordermark D,Bache M
Sat Dec 31 00:00:00 UTC 2022
Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes.
Biochimica et biophysica acta. General subjects
Sawa R,Ohnishi A,Ohno M,Nagata M,Wake I,Okimura Y
Thu Sep 01 00:00:00 UTC 2022
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
Nature communications
Kim K,Yoo HC,Kim BG,Kim S,Sung Y,Yoon I,Yu YC,Park SJ,Kim JH,Myung K,Hwang KY,Kim S,Han JM
Wed May 25 00:00:00 UTC 2022
E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
Molecular cell
Wang D,Xu C,Yang W,Chen J,Ou Y,Guan Y,Guan J,Liu Y
Thu Feb 17 00:00:00 UTC 2022
E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
Molecular cell
Wang D,Xu C,Yang W,Chen J,Ou Y,Guan Y,Guan J,Liu Y
Thu Feb 17 00:00:00 UTC 2022
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Autophagy
Yan G,Li X,Zheng Z,Gao W,Chen C,Wang X,Cheng Z,Yu J,Zou G,Farooq MZ,Zhu X,Zhu W,Zhong Q,Yan X
Thu Dec 01 00:00:00 UTC 2022
Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.
Frontiers in pharmacology
Yan M,Jin S,Liu Y,Wang L,Wang Z,Xia T,Chang Q
Fri Apr 01 00:00:00 UTC 2022
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Science (New York, N.Y.)
Cangelosi AL,Puszynska AM,Roberts JM,Armani A,Nguyen TP,Spinelli JB,Kunchok T,Wang B,Chan SH,Lewis CA,Comb WC,Bell GW,Helman A,Sabatini DM
Fri Jul 01 00:00:00 UTC 2022
Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway.
Antioxidants (Basel, Switzerland)
Kim JK,Yang HJ,Go Y
Tue Sep 20 00:00:00 UTC 2022
Sestrins' Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats.
Gerontology
Wrońska A,Zubrzycki A,Kmieć Z
Wed Jul 06 00:00:00 UTC 2022
Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.
Cancer cell international
Wei J,Zheng X,Li W,Li X,Fu Z
Fri Feb 11 00:00:00 UTC 2022
Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.
Cancer cell international
Wei J,Zheng X,Li W,Li X,Fu Z
Fri Feb 11 00:00:00 UTC 2022
Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.
Cancer cell international
Wei J,Zheng X,Li W,Li X,Fu Z
Fri Feb 11 00:00:00 UTC 2022
Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.
Cancer cell international
Wei J,Zheng X,Li W,Li X,Fu Z
Fri Feb 11 00:00:00 UTC 2022
Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis.
Experimental & molecular medicine
Han D,Kim H,Kim S,Le QA,Han SY,Bae J,Shin HW,Kang HG,Han KH,Shin J,Park HW
Tue Mar 01 00:00:00 UTC 2022
Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.
Cell reports
Wilcock DJ,Badrock AP,Wong CW,Owen R,Guerin M,Southam AD,Johnston H,Telfer BA,Fullwood P,Watson J,Ferguson H,Ferguson J,Lloyd GR,Jankevics A,Dunn WB,Wellbrock C,Lorigan P,Ceol C,Francavilla C,Smith MP,Hurlstone AFL
Tue Jun 21 00:00:00 UTC 2022
ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.
The Journal of clinical investigation
Kouzu H,Tatekoshi Y,Chang HC,Shapiro JS,McGee WA,De Jesus A,Ben-Sahra I,Arany Z,Leor J,Chen C,Blackshear PJ,Ardehali H
Mon May 16 00:00:00 UTC 2022
Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1.
Cells
Blagojevic B,Almouhanna F,Poschet G,Wölfl S
Wed Nov 30 00:00:00 UTC 2022
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
The Journal of nutritional biochemistry
Yu C,Liu S,Niu Y,Fu L
Thu Sep 01 00:00:00 UTC 2022
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Redox biology
Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J
Wed Jun 01 00:00:00 UTC 2022
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Redox biology
Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J
Wed Jun 01 00:00:00 UTC 2022
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Redox biology
Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J
Wed Jun 01 00:00:00 UTC 2022
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Redox biology
Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J
Wed Jun 01 00:00:00 UTC 2022
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.
Cell death & disease
Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L
Fri Sep 09 00:00:00 UTC 2022
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.
Cell death & disease
Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L
Fri Sep 09 00:00:00 UTC 2022
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.
Cell death & disease
Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L
Fri Sep 09 00:00:00 UTC 2022
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.
Cell death & disease
Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L
Fri Sep 09 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Cell death & disease
Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y
Sat Jul 30 00:00:00 UTC 2022
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation.
Brain, behavior, and immunity
Sun J,Song FH,Wu JY,Zhang LQ,Li DY,Gao SJ,Liu DQ,Zhou YQ,Mei W
Sun May 01 00:00:00 UTC 2022
SESN2/NRF2 signaling activates as a direct downstream regulator of the PERK pathway against endoplasmic reticulum stress to improve the in vitro maturation of porcine oocytes.
Free radical biology & medicine
Park HJ,Yang SG,Koo DB
Sat Jan 01 00:00:00 UTC 2022
SESN2/NRF2 signaling activates as a direct downstream regulator of the PERK pathway against endoplasmic reticulum stress to improve the in vitro maturation of porcine oocytes.
Free radical biology & medicine
Park HJ,Yang SG,Koo DB
Sat Jan 01 00:00:00 UTC 2022
Leucine retention in lysosomes is regulated by starvation.
Proceedings of the National Academy of Sciences of the United States of America
Bandyopadhyay U,Todorova P,Pavlova NN,Tada Y,Thompson CB,Finley LWS,Overholtzer M
Tue Feb 08 00:00:00 UTC 2022
Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.
MethodsX
Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F
Fri Dec 02 00:00:00 UTC 2022
Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.
MethodsX
Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F
Fri Dec 02 00:00:00 UTC 2022
Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.
MethodsX
Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F
Fri Dec 02 00:00:00 UTC 2022
Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells.
Frontiers in pharmacology
Qu N,Qu J,Huang N,Zhang K,Ye T,Shi J,Chen B,Kan C,Zhang J,Han F,Hou N,Sun X,Pan R
Tue Jan 03 00:00:00 UTC 2023
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Molecular cell
Fiore A,Zeitler L,Russier M,Groß A,Hiller MK,Parker JL,Stier L,Köcher T,Newstead S,Murray PJ
Thu Mar 03 00:00:00 UTC 2022
Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway.
Journal of cellular physiology
Chen M,Xi Y,Chen K,Xiao P,Li S,Sun X,Han Z
Fri Jan 01 00:00:00 UTC 2021
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Human & experimental toxicology
Liu X,Li M,Zhu J,Huang W,Song J
Thu Jul 01 00:00:00 UTC 2021
Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction.
Frontiers in cell and developmental biology
Oh SY,Kang N,Kang JY,Kim KW,Choi JH,Yang YM,Shin DM
Tue Apr 13 00:00:00 UTC 2021
The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Sawa R,Wake I,Yamamoto Y,Okimura Y
Sun Aug 01 00:00:00 UTC 2021
Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload.
Frontiers in pharmacology
Zhang N,Liao HH,Feng H,Mou SQ,Li WJ,Aiyasiding X,Lin Z,Ding W,Zhou ZY,Yan H,Chen S,Tang QZ
Tue Dec 07 00:00:00 UTC 2021
Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages.
Life sciences
Wu D,Zhang H,Wu Q,Li F,Wang Y,Liu S,Wang J
Mon Feb 15 00:00:00 UTC 2021
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Free radical biology & medicine
Hsieh YH,Chao AC,Lin YC,Chen SD,Yang DI
Tue Jun 01 00:00:00 UTC 2021
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.
Neurobiology of disease
Mirra S,García-Arroyo R,B Domènech E,Gavaldà-Navarro A,Herrera-Úbeda C,Oliva C,Garcia-Fernàndez J,Artuch R,Villarroya F,Marfany G
Sun Aug 01 00:00:00 UTC 2021
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.
Neurobiology of disease
Mirra S,García-Arroyo R,B Domènech E,Gavaldà-Navarro A,Herrera-Úbeda C,Oliva C,Garcia-Fernàndez J,Artuch R,Villarroya F,Marfany G
Sun Aug 01 00:00:00 UTC 2021
Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis.
Nutrients
Veenstra JP,Vemu B,Tocmo R,Nauman MC,Johnson JJ
Sat Feb 27 00:00:00 UTC 2021
Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle-aged men.
American journal of physiology. Cell physiology
Zeng N,D'Souza RF,MacRae CL,Figueiredo VC,Pileggi CA,Markworth JF,Merry TL,Cameron-Smith D,Mitchell CJ
Thu Apr 01 00:00:00 UTC 2021
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
BMC cancer
Jang SK,Hong SE,Lee DH,Kim JY,Kim JY,Ye SK,Hong J,Park IC,Jin HO
Mon Jul 12 00:00:00 UTC 2021
Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer.
Gastroenterology research and practice
Fu H,Ni X,Ni F,Li D,Sun H,Kong H,Shan Y,Dai S
Mon Apr 25 00:00:00 UTC 2022
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Life sciences
Zhang J,Jiang D,Lin S,Cheng Y,Pan J,Ding W,Chen Y,Fan J
Thu Apr 01 00:00:00 UTC 2021
p53 induces a survival transcriptional response after nucleolar stress.
Molecular biology of the cell
Liao H,Gaur A,Mauvais C,Denicourt C
Fri Oct 01 00:00:00 UTC 2021
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
Molecular cell
Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N
Thu Jan 21 00:00:00 UTC 2021
Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs.
Frontiers in physiology
So B,Park J,Jang J,Lim W,Imdad S,Kang C
Wed Feb 23 00:00:00 UTC 2022
SAR1B senses leucine levels to regulate mTORC1 signalling.
Nature
Chen J,Ou Y,Luo R,Wang J,Wang D,Guan J,Li Y,Xia P,Chen PR,Liu Y
Sun Aug 01 00:00:00 UTC 2021
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Proceedings of the National Academy of Sciences of the United States of America
Condon KJ,Orozco JM,Adelmann CH,Spinelli JB,van der Helm PW,Roberts JM,Kunchok T,Sabatini DM
Tue Jan 26 00:00:00 UTC 2021
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.
Molecular cell
Vivas-García Y,Falletta P,Liebing J,Louphrasitthiphol P,Feng Y,Chauhan J,Scott DA,Glodde N,Chocarro-Calvo A,Bonham S,Osterman AL,Fischer R,Ronai Z,García-Jiménez C,Hölzel M,Goding CR
Thu Jan 02 00:00:00 UTC 2020
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
The Journal of experimental medicine
Recouvreux MV,Moldenhauer MR,Galenkamp KMO,Jung M,James B,Zhang Y,Lowy A,Bagchi A,Commisso C
Mon Sep 07 00:00:00 UTC 2020
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
BioMed research international
Du J,He W,Zhang C,Wu J,Li Z,Wang M,Feng S,Liang G
Mon Nov 23 00:00:00 UTC 2020
Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.
International journal of molecular sciences
Kim H,Jeon BT,Kim IM,Bennett SJ,Lorch CM,Viana MP,Myers JF,Trupp CJ,Whipps ZT,Kundu M,Chung S,Sun X,Khalimonchuk O,Lee J,Ro SH
Tue Aug 25 00:00:00 UTC 2020
Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.
International journal of molecular sciences
Kim H,Jeon BT,Kim IM,Bennett SJ,Lorch CM,Viana MP,Myers JF,Trupp CJ,Whipps ZT,Kundu M,Chung S,Sun X,Khalimonchuk O,Lee J,Ro SH
Tue Aug 25 00:00:00 UTC 2020
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Chemico-biological interactions
Fan Y,Xing Y,Xiong L,Wang J
Mon Jun 01 00:00:00 UTC 2020
mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer.
Cancers
Shin J,Bae J,Park S,Kang HG,Shin SM,Won G,Kim JS,Cho SG,Choi Y,Oh SM,Shin J,Kim JS,Park HW
Fri Sep 04 00:00:00 UTC 2020
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Toxicology and applied pharmacology
Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC
Wed Jul 15 00:00:00 UTC 2020
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Toxicology and applied pharmacology
Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC
Wed Jul 15 00:00:00 UTC 2020
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Toxicology and applied pharmacology
Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC
Wed Jul 15 00:00:00 UTC 2020
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Toxicology and applied pharmacology
Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC
Wed Jul 15 00:00:00 UTC 2020
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Brain research
Li Y,Wu J,Yu S,Zhu J,Zhou Y,Wang P,Li L,Zhao Y
Thu Oct 15 00:00:00 UTC 2020
Systematic quantitative analysis of ribosome inventory during nutrient stress.
Nature
An H,Ordureau A,Körner M,Paulo JA,Harper JW
Wed Jul 01 00:00:00 UTC 2020
Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway.
Metallomics : integrated biometal science
Yang D,Han B,Baiyun R,Lv Z,Wang X,Li S,Lv Y,Xue J,Liu Y,Zhang Z
Wed Dec 23 00:00:00 UTC 2020
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Autophagy
Lee DH,Park JS,Lee YS,Han J,Lee DK,Kwon SW,Han DH,Lee YH,Bae SH
Sun Nov 01 00:00:00 UTC 2020
Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
Oncology reports
Qi W,Li Z,Yang C,Jiangshan Dai J,Zhang Q,Wang D,Wu C,Xia L,Xu S
Sun Mar 01 00:00:00 UTC 2020
PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
Molecular cancer therapeutics
Lim JT,Singh N,Leuvano LA,Calvert VS,Petricoin EF,Teachey DT,Lock RB,Padi M,Kraft AS,Padi SKR
Tue Sep 01 00:00:00 UTC 2020
Correlation between sestrin2 expression and airway remodeling in COPD.
BMC pulmonary medicine
Zhang DW,Wei YY,Ji S,Fei GH
Mon Nov 16 00:00:00 UTC 2020
5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes.
Pharmaceutical biology
Chen X,Yang JH,Cho SS,Kim JH,Xu J,Seo K,Ki SH
Tue Dec 01 00:00:00 UTC 2020
Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion.
Redox biology
Ren D,Quan N,Fedorova J,Zhang J,He Z,Li J
Wed Jul 01 00:00:00 UTC 2020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.
Nature communications
Segalés J,Perdiguero E,Serrano AL,Sousa-Victor P,Ortet L,Jardí M,Budanov AV,Garcia-Prat L,Sandri M,Thomson DM,Karin M,Hee Lee J,Muñoz-Cánoves P
Mon Jan 13 00:00:00 UTC 2020
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Chinese journal of integrative medicine
Li W,Jiang YH,Wang Y,Zhao M,Hou GJ,Hu HZ,Zhou L
Wed Jan 01 00:00:00 UTC 2020
The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
The Journal of biological chemistry
Kowalsky AH,Namkoong S,Mettetal E,Park HW,Kazyken D,Fingar DC,Lee JH
Fri Feb 14 00:00:00 UTC 2020
ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
The Journal of nutrition
Xu D,Dai W,Kutzler L,Lacko HA,Jefferson LS,Dennis MD,Kimball SR
Fri May 01 00:00:00 UTC 2020
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Aging
Ding S,Ma N,Liu H,Tang M,Mei J
Tue Nov 24 00:00:00 UTC 2020
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
Annals of geriatric medicine and research
Hwang CY,Han YH,Lee SM,Cho SM,Yu DY,Kwon KS
Tue Dec 01 00:00:00 UTC 2020
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
JCI insight
Kanno A,Asahara SI,Furubayashi A,Masuda K,Yoshitomi R,Suzuki E,Takai T,Kimura-Koyanagi M,Matsuda T,Bartolome A,Hirota Y,Yokoi N,Inaba Y,Inoue H,Matsumoto M,Inoue K,Abe T,Wei FY,Tomizawa K,Ogawa W,Seino S,Kasuga M,Kido Y
Thu May 07 00:00:00 UTC 2020
Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway.
Biochemical and biophysical research communications
Han X,Ding C,Zhang G,Pan R,Liu Y,Huang N,Hou N,Han F,Xu W,Sun X
Thu May 14 00:00:00 UTC 2020
Treatment of ErbB2 breast cancer by mitochondrial targeting.
Cancer & metabolism
Eldad S,Hertz R,Vainer G,Saada A,Bar-Tana J
Fri Apr 15 00:00:00 UTC 2022
Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.
Journal of cellular biochemistry
Sundararajan S,Jayachandran I,Balasubramanyam M,Mohan V,Venkatesan B,Manickam N
Wed May 01 00:00:00 UTC 2019
Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.
Journal of cellular biochemistry
Sundararajan S,Jayachandran I,Balasubramanyam M,Mohan V,Venkatesan B,Manickam N
Wed May 01 00:00:00 UTC 2019
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
Journal of biophotonics
Xia J,Zeng W,Xia Y,Wang B,Xu D,Liu D,Kong MG,Dong Y
Tue Jan 01 00:00:00 UTC 2019
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
Journal of biophotonics
Xia J,Zeng W,Xia Y,Wang B,Xu D,Liu D,Kong MG,Dong Y
Tue Jan 01 00:00:00 UTC 2019
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
Oncotarget
Ding B,Haidurov A,Chawla A,Parmigiani A,van de Kamp G,Dalina A,Yuan F,Lee JH,Chumakov PM,Grossman SR,Budanov AV
Tue Dec 10 00:00:00 UTC 2019
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Xu D,Shimkus KL,Lacko HA,Kutzler L,Jefferson LS,Kimball SR
Wed May 01 00:00:00 UTC 2019
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Free radical biology & medicine
Park JS,Lee YS,Lee DH,Bae SH
Sat Jun 01 00:00:00 UTC 2019
Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK.
Cell death & disease
Jin HR,Du CH,Wang CZ,Yuan CS,Du W
Fri Apr 05 00:00:00 UTC 2019
Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.
Antioxidants & redox signaling
Yang JH,Kim KM,Cho SS,Shin SM,Ka SO,Na CS,Park BH,Jegal KH,Kim JK,Ku SK,Lee HJ,Park SG,Cho IJ,Ki SH
Sat Jul 20 00:00:00 UTC 2019
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Neuroscience
Wang P,Zhao Y,Li Y,Wu J,Yu S,Zhu J,Li L,Zhao Y
Mon Jul 01 00:00:00 UTC 2019
Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.
Toxicology and applied pharmacology
Park SJ,Cho SS,Kim KM,Yang JH,Kim JH,Jeong EH,Yang JW,Han CY,Ku SK,Cho IJ,Ki SH
Sun Sep 15 00:00:00 UTC 2019
Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism.
American journal of cancer research
Rajanala SH,Ringquist R,Cryns VL
Sat Apr 20 00:00:00 UTC 2024
Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.
American journal of physiology. Heart and circulatory physiology
Li R,Huang Y,Semple I,Kim M,Zhang Z,Lee JH
Mon Jul 01 00:00:00 UTC 2019
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Free radical biology & medicine
Shin D,Kim EH,Lee J,Roh JL
Sat Dec 01 00:00:00 UTC 2018
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Free radical biology & medicine
Shin D,Kim EH,Lee J,Roh JL
Sat Dec 01 00:00:00 UTC 2018
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Biochimica et biophysica acta. Molecular basis of disease
Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L
Mon Oct 01 00:00:00 UTC 2018
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Biochimica et biophysica acta. Molecular basis of disease
Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L
Mon Oct 01 00:00:00 UTC 2018
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.
The American journal of Chinese medicine
Jung JY,Park SM,Ko HL,Lee JR,Park CA,Byun SH,Ku SK,Cho IJ,Kim SC
Fri Aug 03 00:00:00 UTC 2018
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.
The American journal of Chinese medicine
Jung JY,Park SM,Ko HL,Lee JR,Park CA,Byun SH,Ku SK,Cho IJ,Kim SC
Fri Aug 03 00:00:00 UTC 2018
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Journal of molecular and cellular cardiology
Quan N,Wang L,Chen X,Luckett C,Cates C,Rousselle T,Zheng Y,Li J
Thu Feb 01 00:00:00 UTC 2018
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Journal of molecular and cellular cardiology
Quan N,Wang L,Chen X,Luckett C,Cates C,Rousselle T,Zheng Y,Li J
Thu Feb 01 00:00:00 UTC 2018
Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Kim JK,Lee JE,Jung EH,Jung JY,Jung DH,Ku SK,Cho IJ,Kim SC
Mon Jan 01 00:00:00 UTC 2018
Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Kim JK,Lee JE,Jung EH,Jung JY,Jung DH,Ku SK,Cho IJ,Kim SC
Mon Jan 01 00:00:00 UTC 2018
The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.
DNA repair
Zheng Y,Lei Q,Jongejan A,Mulder CL,van Daalen SKM,Mastenbroek S,Hwang G,Jordan PW,Repping S,Hamer G
Mon Oct 01 00:00:00 UTC 2018
The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.
DNA repair
Zheng Y,Lei Q,Jongejan A,Mulder CL,van Daalen SKM,Mastenbroek S,Hwang G,Jordan PW,Repping S,Hamer G
Mon Oct 01 00:00:00 UTC 2018
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
Molecular and cellular biochemistry
Kumar A,Shaha C
Sat Sep 01 00:00:00 UTC 2018
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
Molecular and cellular biochemistry
Kumar A,Shaha C
Sat Sep 01 00:00:00 UTC 2018
The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.
European journal of applied physiology
Zeng N,D'Souza RF,Sorrenson B,Merry TL,Barnett MPG,Mitchell CJ,Cameron-Smith D
Fri Jun 01 00:00:00 UTC 2018
The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.
European journal of applied physiology
Zeng N,D'Souza RF,Sorrenson B,Merry TL,Barnett MPG,Mitchell CJ,Cameron-Smith D
Fri Jun 01 00:00:00 UTC 2018
Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation.
The FEBS journal
Kumar A,Giri S,Shaha C
Sun Apr 01 00:00:00 UTC 2018
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Scientific reports
Kumar A,Shaha C
Fri Jan 12 00:00:00 UTC 2018
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Scientific reports
Kumar A,Shaha C
Fri Jan 12 00:00:00 UTC 2018
Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.
Experimental gerontology
Zeng N,D'Souza RF,Mitchell CJ,Cameron-Smith D
Sat Sep 01 00:00:00 UTC 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 UTC 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 UTC 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 UTC 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 UTC 2018
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Marine drugs
Florean C,Kim KR,Schnekenburger M,Kim HJ,Moriou C,Debitus C,Dicato M,Al-Mourabit A,Han BW,Diederich M
Wed Dec 19 00:00:00 UTC 2018
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Marine drugs
Florean C,Kim KR,Schnekenburger M,Kim HJ,Moriou C,Debitus C,Dicato M,Al-Mourabit A,Han BW,Diederich M
Wed Dec 19 00:00:00 UTC 2018
SZT2 dictates GATOR control of mTORC1 signalling.
Nature
Peng M,Yin N,Li MO
Thu Mar 16 00:00:00 UTC 2017
SZT2 dictates GATOR control of mTORC1 signalling.
Nature
Peng M,Yin N,Li MO
Thu Mar 16 00:00:00 UTC 2017
Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.
Matrix biology : journal of the International Society for Matrix Biology
Tomasovic A,Kurrle N,Wempe F,De-Zolt S,Scheibe S,Koli K,Serchinger M,Schnütgen F,Sürün D,Sterner-Kock A,Weissmann N,von Melchner H
Mon May 01 00:00:00 UTC 2017
Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.
Matrix biology : journal of the International Society for Matrix Biology
Tomasovic A,Kurrle N,Wempe F,De-Zolt S,Scheibe S,Koli K,Serchinger M,Schnütgen F,Sürün D,Sterner-Kock A,Weissmann N,von Melchner H
Mon May 01 00:00:00 UTC 2017
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Free radical biology & medicine
Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT
Fri Sep 01 00:00:00 UTC 2017
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Free radical biology & medicine
Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT
Fri Sep 01 00:00:00 UTC 2017
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Archives of pharmacal research
Seo K,Ki SH,Park EY,Shin SM
Wed Feb 01 00:00:00 UTC 2017
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Archives of pharmacal research
Seo K,Ki SH,Park EY,Shin SM
Wed Feb 01 00:00:00 UTC 2017
Sestrin2 protects against acetaminophen-induced liver injury.
Chemico-biological interactions
Kim SJ,Kim KM,Yang JH,Cho SS,Kim JY,Park SJ,Lee SK,Ku SK,Cho IJ,Ki SH
Mon May 01 00:00:00 UTC 2017
Sestrin2 protects against acetaminophen-induced liver injury.
Chemico-biological interactions
Kim SJ,Kim KM,Yang JH,Cho SS,Kim JY,Park SJ,Lee SK,Ku SK,Cho IJ,Ki SH
Mon May 01 00:00:00 UTC 2017
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Biochimica et biophysica acta. Molecular cell research
Jegal KH,Park SM,Cho SS,Byun SH,Ku SK,Kim SC,Ki SH,Cho IJ
Sat Jul 01 00:00:00 UTC 2017
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Biochimica et biophysica acta. Molecular cell research
Jegal KH,Park SM,Cho SS,Byun SH,Ku SK,Kim SC,Ki SH,Cho IJ
Sat Jul 01 00:00:00 UTC 2017
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Experimental cell research
Li H,Liu S,Yuan H,Niu Y,Fu L
Mon May 01 00:00:00 UTC 2017
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Experimental cell research
Li H,Liu S,Yuan H,Niu Y,Fu L
Mon May 01 00:00:00 UTC 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 UTC 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 UTC 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 UTC 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 UTC 2017
Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.
Photochemistry and photobiology
Zhao B,Shah P,Qiang L,He TC,Budanov A,He YY
Sun Jan 01 00:00:00 UTC 2017
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Experimental and therapeutic medicine
Xing Y,Liu YX,Liu X,Wang SL,Li P,Lin XH,Sui CL,Xu C,Qi B,Tong Q
Thu Jun 01 00:00:00 UTC 2017
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Experimental and therapeutic medicine
Xing Y,Liu YX,Liu X,Wang SL,Li P,Lin XH,Sui CL,Xu C,Qi B,Tong Q
Thu Jun 01 00:00:00 UTC 2017
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 UTC 2020
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 UTC 2020
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 UTC 2020
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 UTC 2020
Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.
Physiological reports
Zeng N,D'Souza RF,Figueiredo VC,Markworth JF,Roberts LA,Peake JM,Mitchell CJ,Cameron-Smith D
Fri Dec 01 00:00:00 UTC 2017
Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.
Physiological reports
Zeng N,D'Souza RF,Figueiredo VC,Markworth JF,Roberts LA,Peake JM,Mitchell CJ,Cameron-Smith D
Fri Dec 01 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 UTC 2017
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Quan N,Sun W,Wang L,Chen X,Bogan JS,Zhou X,Cates C,Liu Q,Zheng Y,Li J
Fri Sep 01 00:00:00 UTC 2017
Stem cell function and stress response are controlled by protein synthesis.
Nature
Blanco S,Bandiera R,Popis M,Hussain S,Lombard P,Aleksic J,Sajini A,Tanna H,Cortés-Garrido R,Gkatza N,Dietmann S,Frye M
Thu Jun 16 00:00:00 UTC 2016
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Autophagy
Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH
Tue Aug 02 00:00:00 UTC 2016
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Autophagy
Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH
Tue Aug 02 00:00:00 UTC 2016
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.
Free radical biology & medicine
Seo K,Seo S,Ki SH,Shin SM
Thu Dec 01 00:00:00 UTC 2016
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.
Free radical biology & medicine
Seo K,Seo S,Ki SH,Shin SM
Thu Dec 01 00:00:00 UTC 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 UTC 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 UTC 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 UTC 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 UTC 2016
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Molecular neurobiology
Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI
Mon Aug 01 00:00:00 UTC 2016
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Molecular neurobiology
Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI
Mon Aug 01 00:00:00 UTC 2016
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.
Apoptosis : an international journal on programmed cell death
Jegal KH,Ko HL,Park SM,Byun SH,Kang KW,Cho IJ,Kim SC
Sun May 01 00:00:00 UTC 2016
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.
Apoptosis : an international journal on programmed cell death
Jegal KH,Ko HL,Park SM,Byun SH,Kang KW,Cho IJ,Kim SC
Sun May 01 00:00:00 UTC 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Cellular signalling
Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS
Mon Aug 01 00:00:00 UTC 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Cellular signalling
Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS
Mon Aug 01 00:00:00 UTC 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Cellular signalling
Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS
Mon Aug 01 00:00:00 UTC 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Cellular signalling
Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS
Mon Aug 01 00:00:00 UTC 2016
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.
Toxicological sciences : an official journal of the Society of Toxicology
Sun W,Quan N,Wang L,Yang H,Chu D,Liu Q,Zhao X,Leng J,Li J
Sun May 01 00:00:00 UTC 2016
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.
Toxicological sciences : an official journal of the Society of Toxicology
Sun W,Quan N,Wang L,Yang H,Chu D,Liu Q,Zhao X,Leng J,Li J
Sun May 01 00:00:00 UTC 2016
Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.
Biological & pharmaceutical bulletin
Seo K,Seo S,Ki SH,Shin SM
Fri Jan 27 00:00:00 UTC 2017
Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.
Biological & pharmaceutical bulletin
Seo K,Seo S,Ki SH,Shin SM
Fri Jan 27 00:00:00 UTC 2017
JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Becattini B,Zani F,Breasson L,Sardi C,D'Agostino VG,Choo MK,Provenzani A,Park JM,Solinas G
Thu Sep 01 00:00:00 UTC 2016
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Free radical research
Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH
Thu Dec 01 00:00:00 UTC 2016
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Free radical research
Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH
Thu Dec 01 00:00:00 UTC 2016
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.
Cell reports
Reddy K,Cusack CL,Nnah IC,Khayati K,Saqcena C,Huynh TB,Noggle SA,Ballabio A,Dobrowolski R
Tue Mar 08 00:00:00 UTC 2016
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.
Cell reports
Reddy K,Cusack CL,Nnah IC,Khayati K,Saqcena C,Huynh TB,Noggle SA,Ballabio A,Dobrowolski R
Tue Mar 08 00:00:00 UTC 2016
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
eLife
Ro SH,Xue X,Ramakrishnan SK,Cho CS,Namkoong S,Jang I,Semple IA,Ho A,Park HW,Shah YM,Lee JH
Thu Feb 25 00:00:00 UTC 2016
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
eLife
Ro SH,Xue X,Ramakrishnan SK,Cho CS,Namkoong S,Jang I,Semple IA,Ho A,Park HW,Shah YM,Lee JH
Thu Feb 25 00:00:00 UTC 2016
The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.
PloS one
Mlitz V,Gendronneau G,Berlin I,Buchberger M,Eckhart L,Tschachler E
Mon Jun 26 00:00:00 UTC 2017
The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.
PloS one
Mlitz V,Gendronneau G,Berlin I,Buchberger M,Eckhart L,Tschachler E
Mon Jun 26 00:00:00 UTC 2017
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Scientific reports
Li L,Xiao L,Hou Y,He Q,Zhu J,Li Y,Wu J,Zhao J,Yu S,Zhao Y
Mon Jul 25 00:00:00 UTC 2016
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Scientific reports
Li L,Xiao L,Hou Y,He Q,Zhu J,Li Y,Wu J,Zhao J,Yu S,Zhao Y
Mon Jul 25 00:00:00 UTC 2016
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.
Scientific reports
Ding B,Parmigiani A,Divakaruni AS,Archer K,Murphy AN,Budanov AV
Wed Mar 02 00:00:00 UTC 2016
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.
Scientific reports
Ding B,Parmigiani A,Divakaruni AS,Archer K,Murphy AN,Budanov AV
Wed Mar 02 00:00:00 UTC 2016
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Genes & development
Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB
Sun Nov 15 00:00:00 UTC 2015
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Genes & development
Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB
Sun Nov 15 00:00:00 UTC 2015
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Diabetes
Tao R,Xiong X,Liangpunsakul S,Dong XC
Wed Apr 01 00:00:00 UTC 2015
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Diabetes
Tao R,Xiong X,Liangpunsakul S,Dong XC
Wed Apr 01 00:00:00 UTC 2015
Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.
Free radical biology & medicine
Yang JH,Kim KM,Kim MG,Seo KH,Han JY,Ka SO,Park BH,Shin SM,Ku SK,Cho IJ,Ki SH
Thu Jan 01 00:00:00 UTC 2015
Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.
Free radical biology & medicine
Yang JH,Kim KM,Kim MG,Seo KH,Han JY,Ka SO,Park BH,Shin SM,Ku SK,Cho IJ,Ki SH
Thu Jan 01 00:00:00 UTC 2015
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Morrison A,Chen L,Wang J,Zhang M,Yang H,Ma Y,Budanov A,Lee JH,Karin M,Li J
Sun Feb 01 00:00:00 UTC 2015
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Morrison A,Chen L,Wang J,Zhang M,Yang H,Ma Y,Budanov A,Lee JH,Karin M,Li J
Sun Feb 01 00:00:00 UTC 2015
Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.
Cell cycle (Georgetown, Tex.)
Ding B,Parmigiani A,Yang C,Budanov AV
Thu Aug 18 00:00:00 UTC 2016
Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.
Cell cycle (Georgetown, Tex.)
Ding B,Parmigiani A,Yang C,Budanov AV
Thu Aug 18 00:00:00 UTC 2016
Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.
Cellular signalling
Seo K,Ki SH,Shin SM
Wed Jul 01 00:00:00 UTC 2015
Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.
Cellular signalling
Seo K,Ki SH,Shin SM
Wed Jul 01 00:00:00 UTC 2015
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Cellular signalling
Yamani L,Li B,Larose L
Tue Dec 01 00:00:00 UTC 2015
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Cellular signalling
Yamani L,Li B,Larose L
Tue Dec 01 00:00:00 UTC 2015
Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.
The Journal of nutrition
Kimball SR,Ravi S,Gordon BS,Dennis MD,Jefferson LS
Sun Nov 01 00:00:00 UTC 2015
Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.
The Journal of nutrition
Kimball SR,Ravi S,Gordon BS,Dennis MD,Jefferson LS
Sun Nov 01 00:00:00 UTC 2015
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
International journal of endocrinology
Chai D,Wang G,Zhou Z,Yang H,Yu Z
Fri Mar 20 00:00:00 UTC 2015
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
International journal of endocrinology
Chai D,Wang G,Zhou Z,Yang H,Yu Z
Fri Mar 20 00:00:00 UTC 2015
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Nature communications
Kim H,An S,Ro SH,Teixeira F,Park GJ,Kim C,Cho CS,Kim JS,Jakob U,Lee JH,Cho US
Fri Nov 27 00:00:00 UTC 2015
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Nature communications
Kim H,An S,Ro SH,Teixeira F,Park GJ,Kim C,Cho CS,Kim JS,Jakob U,Lee JH,Cho US
Fri Nov 27 00:00:00 UTC 2015
The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
Toxicology and applied pharmacology
Han JY,Cho SS,Yang JH,Kim KM,Jang CH,Park DE,Bang JS,Jung YS,Ki SH
Sat Aug 15 00:00:00 UTC 2015
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Toxicological sciences : an official journal of the Society of Toxicology
Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH
Wed Apr 01 00:00:00 UTC 2015
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Toxicological sciences : an official journal of the Society of Toxicology
Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH
Wed Apr 01 00:00:00 UTC 2015
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Toxicological sciences : an official journal of the Society of Toxicology
Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH
Wed Apr 01 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 UTC 2015
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Cell
Peng M,Yin N,Li MO
Thu Sep 25 00:00:00 UTC 2014
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Cell
Peng M,Yin N,Li MO
Thu Sep 25 00:00:00 UTC 2014
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America
Ro SH,Nam M,Jang I,Park HW,Park H,Semple IA,Kim M,Kim JS,Park H,Einat P,Damari G,Golikov M,Feinstein E,Lee JH
Tue May 27 00:00:00 UTC 2014
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America
Ro SH,Nam M,Jang I,Park HW,Park H,Semple IA,Kim M,Kim JS,Park H,Einat P,Damari G,Golikov M,Feinstein E,Lee JH
Tue May 27 00:00:00 UTC 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 UTC 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 UTC 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 UTC 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 UTC 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 UTC 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 UTC 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 UTC 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 UTC 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 UTC 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 UTC 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 UTC 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 UTC 2014
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
International journal of molecular medicine
Kim GT,Lee SH,Kim JI,Kim YM
Tue Apr 01 00:00:00 UTC 2014
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
International journal of molecular medicine
Kim GT,Lee SH,Kim JI,Kim YM
Tue Apr 01 00:00:00 UTC 2014
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Toxicology
Solhaug A,Torgersen ML,Holme JA,Lagadic-Gossmann D,Eriksen GS
Thu Dec 04 00:00:00 UTC 2014
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Toxicology
Solhaug A,Torgersen ML,Holme JA,Lagadic-Gossmann D,Eriksen GS
Thu Dec 04 00:00:00 UTC 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 UTC 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 UTC 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 UTC 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 UTC 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 UTC 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 UTC 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 UTC 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 UTC 2014
Hepatoprotective role of Sestrin2 against chronic ER stress.
Nature communications
Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH
Fri Jun 20 00:00:00 UTC 2014
Hepatoprotective role of Sestrin2 against chronic ER stress.
Nature communications
Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH
Fri Jun 20 00:00:00 UTC 2014
Hepatoprotective role of Sestrin2 against chronic ER stress.
Nature communications
Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH
Fri Jun 20 00:00:00 UTC 2014
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
The Journal of biological chemistry
Cam M,Bid HK,Xiao L,Zambetti GP,Houghton PJ,Cam H
Fri Feb 14 00:00:00 UTC 2014
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
The Journal of biological chemistry
Cam M,Bid HK,Xiao L,Zambetti GP,Houghton PJ,Cam H
Fri Feb 14 00:00:00 UTC 2014
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 UTC 2014
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 UTC 2014
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 UTC 2014
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 UTC 2014
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 UTC 2013
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 UTC 2013
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 UTC 2013
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 UTC 2013
The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Hepatology (Baltimore, Md.)
Buitrago-Molina LE,Marhenke S,Longerich T,Sharma AD,Boukouris AE,Geffers R,Guigas B,Manns MP,Vogel A
Sun Sep 01 00:00:00 UTC 2013
The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Hepatology (Baltimore, Md.)
Buitrago-Molina LE,Marhenke S,Longerich T,Sharma AD,Boukouris AE,Geffers R,Guigas B,Manns MP,Vogel A
Sun Sep 01 00:00:00 UTC 2013
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Cell death and differentiation
Ben-Sahra I,Dirat B,Laurent K,Puissant A,Auberger P,Budanov A,Tanti JF,Bost F
Mon Apr 01 00:00:00 UTC 2013
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Cell death and differentiation
Ben-Sahra I,Dirat B,Laurent K,Puissant A,Auberger P,Budanov A,Tanti JF,Bost F
Mon Apr 01 00:00:00 UTC 2013
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Antioxidants & redox signaling
Kallenborn-Gerhardt W,Lu R,Syhr KM,Heidler J,von Melchner H,Geisslinger G,Bangsow T,Schmidtko A
Tue Dec 10 00:00:00 UTC 2013
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Antioxidants & redox signaling
Kallenborn-Gerhardt W,Lu R,Syhr KM,Heidler J,von Melchner H,Geisslinger G,Bangsow T,Schmidtko A
Tue Dec 10 00:00:00 UTC 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 UTC 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 UTC 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 UTC 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 UTC 2013
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Toxicology and applied pharmacology
Jin SH,Yang JH,Shin BY,Seo K,Shin SM,Cho IJ,Ki SH
Thu Aug 15 00:00:00 UTC 2013
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Toxicology and applied pharmacology
Jin SH,Yang JH,Shin BY,Seo K,Shin SM,Cho IJ,Ki SH
Thu Aug 15 00:00:00 UTC 2013
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Disease models & mechanisms
Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H
Fri Nov 01 00:00:00 UTC 2013
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Disease models & mechanisms
Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H
Fri Nov 01 00:00:00 UTC 2013
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Disease models & mechanisms
Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H
Fri Nov 01 00:00:00 UTC 2013
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Disease models & mechanisms
Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H
Fri Nov 01 00:00:00 UTC 2013
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
PloS one
Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC
Mon Jul 07 00:00:00 UTC 2014
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
PloS one
Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC
Mon Jul 07 00:00:00 UTC 2014
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.
Journal of cancer prevention
Kim GT,Lee SH,Kim YM
Sun Sep 01 00:00:00 UTC 2013
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.
Journal of cancer prevention
Kim GT,Lee SH,Kim YM
Sun Sep 01 00:00:00 UTC 2013
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Cell metabolism
Lee JH,Budanov AV,Talukdar S,Park EJ,Park HL,Park HW,Bandyopadhyay G,Li N,Aghajan M,Jang I,Wolfe AM,Perkins GA,Ellisman MH,Bier E,Scadeng M,Foretz M,Viollet B,Olefsky J,Karin M
Wed Sep 05 00:00:00 UTC 2012
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Cell metabolism
Lee JH,Budanov AV,Talukdar S,Park EJ,Park HL,Park HW,Bandyopadhyay G,Li N,Aghajan M,Jang I,Wolfe AM,Perkins GA,Ellisman MH,Bier E,Scadeng M,Foretz M,Viollet B,Olefsky J,Karin M
Wed Sep 05 00:00:00 UTC 2012
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Free radical biology & medicine
Shin BY,Jin SH,Cho IJ,Ki SH
Wed Aug 15 00:00:00 UTC 2012
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Free radical biology & medicine
Shin BY,Jin SH,Cho IJ,Ki SH
Wed Aug 15 00:00:00 UTC 2012
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Free radical biology & medicine
Shin BY,Jin SH,Cho IJ,Ki SH
Wed Aug 15 00:00:00 UTC 2012
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL
Sat Sep 01 00:00:00 UTC 2012
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL
Sat Sep 01 00:00:00 UTC 2012
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL
Sat Sep 01 00:00:00 UTC 2012
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Biochemical pharmacology
Caporali S,Alvino E,Levati L,Esposito AI,Ciomei M,Brasca MG,Del Bufalo D,Desideri M,Bonmassar E,Pfeffer U,D'Atri S
Sat Sep 01 00:00:00 UTC 2012
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Biochemical pharmacology
Caporali S,Alvino E,Levati L,Esposito AI,Ciomei M,Brasca MG,Del Bufalo D,Desideri M,Bonmassar E,Pfeffer U,D'Atri S
Sat Sep 01 00:00:00 UTC 2012
Highly reactive meso-like positions of dipyrihexaphyrin.
Chemical communications (Cambridge, England)
Setsune J,Yamato K
Fri May 11 00:00:00 UTC 2012
Highly reactive meso-like positions of dipyrihexaphyrin.
Chemical communications (Cambridge, England)
Setsune J,Yamato K
Fri May 11 00:00:00 UTC 2012
Mechanisms involved in alternariol-induced cell cycle arrest.
Mutation research
Solhaug A,Vines LL,Ivanova L,Spilsberg B,Holme JA,Pestka J,Collins A,Eriksen GS
Tue Feb 26 00:00:00 UTC 2013
Mechanisms involved in alternariol-induced cell cycle arrest.
Mutation research
Solhaug A,Vines LL,Ivanova L,Spilsberg B,Holme JA,Pestka J,Collins A,Eriksen GS
Tue Feb 26 00:00:00 UTC 2013
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 UTC 2012
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 UTC 2012
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 UTC 2012
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 UTC 2012
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
American journal of physiology. Endocrinology and metabolism
Lang CH,Frost RA,Bronson SK,Lynch CJ,Vary TC
Tue Jun 01 00:00:00 UTC 2010
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
American journal of physiology. Endocrinology and metabolism
Lang CH,Frost RA,Bronson SK,Lynch CJ,Vary TC
Tue Jun 01 00:00:00 UTC 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 UTC 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 UTC 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 UTC 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 UTC 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 UTC 2010
Artemis is a negative regulator of p53 in response to oxidative stress.
Oncogene
Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ
Thu Jun 04 00:00:00 UTC 2009
Artemis is a negative regulator of p53 in response to oxidative stress.
Oncogene
Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ
Thu Jun 04 00:00:00 UTC 2009
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Antioxidants & redox signaling
Woo HA,Bae SH,Park S,Rhee SG
Wed Apr 01 00:00:00 UTC 2009
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Antioxidants & redox signaling
Woo HA,Bae SH,Park S,Rhee SG
Wed Apr 01 00:00:00 UTC 2009
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Antioxidants & redox signaling
Woo HA,Bae SH,Park S,Rhee SG
Wed Apr 01 00:00:00 UTC 2009
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.
Journal of neurochemistry
Doonan F,Wallace DM,O'Driscoll C,Cotter TG
Wed Apr 01 00:00:00 UTC 2009
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.
Journal of neurochemistry
Doonan F,Wallace DM,O'Driscoll C,Cotter TG
Wed Apr 01 00:00:00 UTC 2009
Role of sestrin2 in peroxide signaling in macrophages.
FEBS letters
Essler S,Dehne N,Brüne B
Tue Nov 03 00:00:00 UTC 2009
Role of sestrin2 in peroxide signaling in macrophages.
FEBS letters
Essler S,Dehne N,Brüne B
Tue Nov 03 00:00:00 UTC 2009
A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.
Investigative ophthalmology & visual science
O'Connor JC,Wallace DM,O'Brien CJ,Cotter TG
Wed Oct 01 00:00:00 UTC 2008
A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.
Investigative ophthalmology & visual science
O'Connor JC,Wallace DM,O'Brien CJ,Cotter TG
Wed Oct 01 00:00:00 UTC 2008
Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.
Journal of cell science
Ding B,Chi SG,Kim SH,Kang S,Cho JH,Kim DS,Cho NH
Sun Jul 01 00:00:00 UTC 2007
Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.
Journal of cell science
Ding B,Chi SG,Kim SH,Kang S,Cho JH,Kim DS,Cho NH
Sun Jul 01 00:00:00 UTC 2007
