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AbboMax
Sgt-1A Monoclonal Antibody (5B12F5)
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FIGURE: 1 / 1
Sgt-1A Antibody (606-240) in IHC (P)
Immunohistochemistry: Human testis tissue (FFPE) stained with Mouse anti-sgt-1A (Cat# 606-240) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
606-240
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5B12F5
Immunogen
A recombinant protein Sgt A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: Testis
Cellular location: Nucleus.
Target Information
This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. Human Sgt1 (Suppressor of the G2 allele of Skp1) has been found to have two isoforms: Sgt-1A and Sgt-1B. This protein interacts with heat shock protein 90. Sgt1 protein translocates to the nucleus due to heat shock and the Ca(2+)-bound form of S100A6 is required for Sgt1 translocation. S100A6-Ca(2+)-mediated Sgt1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the Sgt1-Hsp90 complex. SUGT1(Sgt-1) protein expression was shown in lung , testis, liver, and brain. It is overexpressed in human colorectal cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein 40-6-3; Protein SGT1 homolog; putative 40-6-3 protein; Sgt1; SGT1, suppressor of G2 allele of SKP1; Suppressor of G2 allele of SKP1 homolog; suppressor of G2 allele of SKP1, S. cerevisiae, homolog of
Gene Aliases: SGT1; SUGT1
UniProt ID: (Human) Q9Y2Z0
Entrez Gene ID: (Human) 10910
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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