Product References
The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors.
British journal of pharmacology
Ruiz-Cantero MC,Cortés-Montero E,Jain A,Montilla-García Á,Bravo-Caparrós I,Shim J,Sánchez-Blázquez P,Woolf CJ,Baeyens JM,Cobos EJ
Published figure using Sigma-1 Receptor polyclonal antibody (Product # 42-3300) in Western Blot
Sat Apr 01 00:00:00 UTC 2023
αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers.
International journal of molecular sciences
Garzón-Niño J,Cortés-Montero E,Rodríguez-Muñoz M,Sánchez-Blázquez P
42-3300 was used in Western Blot, Immunohistochemistry to suggest that the pharmacological ß-Endorphin-specific epsilon receptor is a s1R-regulated MOR and that ß-Endorphin and aN-acetyl ß-Endorphin are endogenous ligands of s1R.
Thu Dec 29 00:00:00 UTC 2022
αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers.
International journal of molecular sciences
Garzón-Niño J,Cortés-Montero E,Rodríguez-Muñoz M,Sánchez-Blázquez P
42-3300 was used in Western Blot, Immunohistochemistry to suggest that the pharmacological ß-Endorphin-specific epsilon receptor is a s1R-regulated MOR and that ß-Endorphin and aN-acetyl ß-Endorphin are endogenous ligands of s1R.
Thu Dec 29 00:00:00 UTC 2022
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
Nature cardiovascular research
Song L,Bekdash R,Morikawa K,Quejada JR,Klein AD,Aina-Badejo D,Yoshida K,Yamamoto HE,Chalan A,Yang R,Patel A,Sirabella D,Lee TM,Joseph LC,Kawano F,Warren JS,Soni RK,Morrow JP,Yazawa M
42-3300 was used in Western Blot to demonstrate that SIGMAR1 is a potential therapeutic target for Timothy syndrome and possibly other inherited arrhythmias such as LQTS1 and LQTS2.
Tue Feb 01 00:00:00 UTC 2022
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
Nature cardiovascular research
Song L,Bekdash R,Morikawa K,Quejada JR,Klein AD,Aina-Badejo D,Yoshida K,Yamamoto HE,Chalan A,Yang R,Patel A,Sirabella D,Lee TM,Joseph LC,Kawano F,Warren JS,Soni RK,Morrow JP,Yazawa M
42-3300 was used in Western Blot to demonstrate that SIGMAR1 is a potential therapeutic target for Timothy syndrome and possibly other inherited arrhythmias such as LQTS1 and LQTS2.
Tue Feb 01 00:00:00 UTC 2022
The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain.
Biomolecules
Rodríguez-Muñoz M,Cortés-Montero E,Onetti Y,Sánchez-Blázquez P,Garzón-Niño J
Published figure using Sigma-1 Receptor polyclonal antibody (Product # 42-3300) in Western Blot
Fri Nov 12 00:00:00 UTC 2021
Region-Dependent Modulation of Neural Plasticity in Limbic Structures Early after Traumatic Brain Injury.
Neurotrauma reports
Hoffman AN,Watson S,Fanselow MS,Hovda DA,Giza C
42-3300 was used in Western Blotting to measured how synaptic proteins respond to lateral fluid percussion injury brain regions known to regulate emotion and memory, including the basolateral amygdala, dorsal and ventral hippocampus, and medial prefrontal cortex.
Tue May 04 00:00:00 UTC 2021
The ALS-related σ1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium.
International journal of molecular sciences
Rodríguez-Muñoz M,Cortés-Montero E,Garzón-Niño J,Sánchez-Blázquez P
Published figure using Sigma-1 Receptor polyclonal antibody (Product # 42-3300) in Western Blot
Sun Oct 04 00:00:00 UTC 2020
Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue.
International journal of molecular sciences
Cortés-Montero E,Rodríguez-Muñoz M,Ruiz-Cantero MDC,Cobos EJ,Sánchez-Blázquez P,Garzón-Niño J
42-3300 was used in Western Blotting to suggest that TRPA1 channels functionally associate with MORs, delta opioid receptors and NMDARs in the dorsal root ganglia, the spinal cord and brain areas.
Mon Dec 28 00:00:00 UTC 2020
Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.
Circulation
Wu S,Lu Q,Ding Y,Wu Y,Qiu Y,Wang P,Mao X,Huang K,Xie Z,Zou MH
42-3300 was used in Western Blotting to determine whether the diabetes mellitus-induced Fundc1 expression could increase MAM formation, and whether disruption of MAM formation improves diabetic cardiac function.
Tue Apr 16 00:00:00 UTC 2019
The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease.
Antioxidants & redox signaling
Cortés-Montero E,Rodríguez-Muñoz M,Sánchez-Blázquez P,Garzón J
42-3300 was used in Functional assay to demonstrate that HINT1 exhibits cysteine protease activity to remove SUMO from a variety of signaling proteins.
Sun Sep 01 00:00:00 UTC 2019
Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.
Frontiers in pharmacology
Cortés-Montero E,Sánchez-Blázquez P,Onetti Y,Merlos M,Garzón J
Published figure using Sigma-1 Receptor polyclonal antibody (Product # 42-3300) in Western Blot
Thu Oct 01 00:00:00 UTC 2020
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Molecular brain
Rodríguez-Muñoz M,Onetti Y,Cortés-Montero E,Garzón J,Sánchez-Blázquez P
42-3300 was used in Western Blotting to demonstrate that cannabidiol displays antagonist-like activity toward s1R to reduce the negative effects of N-methyl-D-aspartate acid receptor overactivity.
Mon Sep 17 00:00:00 UTC 2018
σ1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Hosszu A,Antal Z,Lenart L,Hodrea J,Koszegi S,Balogh DB,Banki NF,Wagner L,Denes A,Hamar P,Degrell P,Vannay A,Szabo AJ,Fekete A
42-3300 was used in Western Blotting to investigate the potential role of σ1-receptor activation in mediating protection from renal ischaemia-reperfusion injury in male rats.
Sun Jan 01 00:00:00 UTC 2017
Modulation of mesenteric collecting lymphatic contractions by σ1-receptor activation and nitric oxide production.
American journal of physiology. Heart and circulatory physiology
Trujillo AN,Katnik C,Cuevas J,Cha BJ,Taylor-Clark TE,Breslin JW
42-3300 was used in Western Blotting to investigate whether the activation of σ-receptors would reduce or weaken collecting lymphatic contractions.
Sun Oct 01 00:00:00 UTC 2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications
Sambo DO,Lin M,Owens A,Lebowitz JJ,Richardson B,Jagnarine DA,Shetty M,Rodriquez M,Alonge T,Ali M,Katz J,Yan L,Febo M,Henry LK,Bruijnzeel AW,Daws L,Khoshbouei H
42-3300 was used in Immunocytochemistry-immunoflourescence to demonstrate that σ1R activation prevents methamphetamine-induced, dopamine transporter-mediated increases in firing activity of dopamine neurons.
Wed Dec 20 00:00:00 UTC 2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications
Sambo DO,Lin M,Owens A,Lebowitz JJ,Richardson B,Jagnarine DA,Shetty M,Rodriquez M,Alonge T,Ali M,Katz J,Yan L,Febo M,Henry LK,Bruijnzeel AW,Daws L,Khoshbouei H
42-3300 was used in Immunocytochemistry-immunoflourescence to demonstrate that σ1R activation prevents methamphetamine-induced, dopamine transporter-mediated increases in firing activity of dopamine neurons.
Wed Dec 20 00:00:00 UTC 2017
Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI.
Theranostics
Shen B,Behera D,James ML,Reyes ST,Andrews L,Cipriano PW,Klukinov M,Lutz AB,Mavlyutov T,Rosenberg J,Ruoho AE,McCurdy CR,Gambhir SS,Yeomans DC,Biswal S,Chin FT
42-3300 was used in Western Blotting to demonstrate the potential of [18F]FTC-146 S1R PET/MR imaging in diagnosing, managing and treating patients with nerve injury.
Mon Apr 30 00:00:00 UTC 2018
Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody.
Neuroscience
Mavlyutov TA,Duellman T,Kim HT,Epstein ML,Leese C,Davletov BA,Yang J
42-3300 was used in immunohistochemistry to utilize a highly specific antibody to monitor sigma-1 receptor expression in the dorsal root ganglion
Wed Sep 07 00:00:00 UTC 2016
The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.
Antioxidants & redox signaling
Rodríguez-Muñoz M,Sánchez-Blázquez P,Herrero-Labrador R,Martínez-Murillo R,Merlos M,Vela JM,Garzón J
42-3300 was used in immunohistochemistry and western blot to test if sigma1R is involved in the negative control that glutamate N-methyl-d-aspartate acid receptors exert on opioid antinociception
Wed Apr 01 00:00:00 UTC 2015
The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.
Antioxidants & redox signaling
Rodríguez-Muñoz M,Sánchez-Blázquez P,Herrero-Labrador R,Martínez-Murillo R,Merlos M,Vela JM,Garzón J
42-3300 was used in immunohistochemistry and western blot to test if sigma1R is involved in the negative control that glutamate N-methyl-d-aspartate acid receptors exert on opioid antinociception
Wed Apr 01 00:00:00 UTC 2015
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Oncotarget
Rodríguez-Muñoz M,Cortés-Montero E,Pozo-Rodrigálvarez A,Sánchez-Blázquez P,Garzón-Niño J
42-3300 was used in western blot to find out how neurological disorders are regulated in terms of sigma1R-HINT1 protein and the GPCR-NMDA receptor
Tue Nov 03 00:00:00 UTC 2015
The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
The international journal of neuropsychopharmacology
Sánchez-Blázquez P,Rodríguez-Muñoz M,Herrero-Labrador R,Burgueño J,Zamanillo D,Garzón J
42-3300 was used in Western Blotting to show that σ1R controls the extent of CB1-NMDAR interaction and its failure might constitute a vulnerability factor for cannabis abuse.
Mon Dec 01 00:00:00 UTC 2014
Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury.
Molecular pain
Bangaru ML,Weihrauch D,Tang QB,Zoga V,Hogan Q,Wu HE
42-3300 was used in western blot to examine σR expression in dorsal root ganglion at baseline and following spinal nerve ligation in rats.
Tue Sep 10 00:00:00 UTC 2013
Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury.
Molecular pain
Bangaru ML,Weihrauch D,Tang QB,Zoga V,Hogan Q,Wu HE
42-3300 was used in western blot to examine σR expression in dorsal root ganglion at baseline and following spinal nerve ligation in rats.
Tue Sep 10 00:00:00 UTC 2013
Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones.
Histochemistry and cell biology
Hayashi T,Lewis A,Hayashi E,Betenbaugh MJ,Su TP
42-3300 was used in immunocytochemistry and western blot to describe a protocol for the immunohistochemical detection of ER chaperones.
Wed Jun 01 00:00:00 UTC 2011
Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones.
Histochemistry and cell biology
Hayashi T,Lewis A,Hayashi E,Betenbaugh MJ,Su TP
42-3300 was used in immunocytochemistry and western blot to describe a protocol for the immunohistochemical detection of ER chaperones.
Wed Jun 01 00:00:00 UTC 2011
Sigma-1 receptors amplify dopamine D1 receptor signaling at presynaptic sites in the prelimbic cortex.
Biochimica et biophysica acta
Fu Y,Zhao Y,Luan W,Dong LY,Dong Y,Lai B,Zhu Y,Zheng P
Wed Dec 01 00:00:00 UTC 2010
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.jpg?time=20250104?time=20250104 "Sigma-1 Receptor Antibody (42-3300) in WB")
