Rockland

Six3 Polyclonal Antibody

View all (15) SIX3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

600-401-A26

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:250
-

ELISA (ELISA)

1:10,000-1:15,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of mouse Six3 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This antibody reacts with mouse Six3. Cross-reactivity with Six3 from other sources has not been determined.

Target Information

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Homeobox protein SIX3; Sine oculis homeobox homolog 3; sine oculis-related homeobox 3 homolog

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Gene Aliases: E130112M24Rik; Six3; Six3a; Six3alpha; Six3b; Six3beta

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UniProt ID: (Mouse) Q62233

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Entrez Gene ID: (Mouse) 20473

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Function(s)
RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcription corepressor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity receptor binding protein binding histone deacetylase binding sequence-specific DNA binding
Process(es)
protein import into nucleus, translocation eye development epithelial cell maturation lens development in camera-type eye optic vesicle morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein import into nucleus multicellular organism development brain development proximal/distal axis specification neuroblast differentiation diencephalon development telencephalon development forebrain anterior/posterior pattern specification forebrain dorsal/ventral pattern formation cell proliferation in forebrain telencephalon regionalization pituitary gland development negative regulation of Wnt signaling pathway regulation of cell proliferation camera-type eye development negative regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter circadian behavior lens induction in camera-type eye regulation of neural retina development lens fiber cell differentiation neuroblast migration regulation of cell cycle phase transition regulation of neuroblast proliferation apoptotic process involved in development lens fiber cell apoptotic process regulation of neural precursor cell proliferation
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