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Invitrogen
SnoN Monoclonal Antibody (OTI3F6)
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SnoN Antibody (MA5-26383) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a SKIL monoclonal antibody (Product # MA5-26383).
Product Details
MA5-26383
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3F6
Immunogen
Human recombinant protein fragment corresponding to amino acids 307-684 of SKIL produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725374
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein
Gene Aliases: SKIL; SNO; SnoA; SnoI; SnoN
UniProt ID: (Human) P12757
Entrez Gene ID: (Human) 6498
negative regulation of transcription from RNA polymerase II promoter
blastocyst formation
lymphocyte homeostasis
cell cycle arrest
transforming growth factor beta receptor signaling pathway
spermatogenesis
negative regulation of transforming growth factor beta receptor signaling pathway
response to cytokine
regulation of apoptotic process
negative regulation of cell differentiation
positive regulation of axonogenesis
lens fiber cell differentiation
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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