Invitrogen

Sodium Channel Pan Polyclonal Antibody

Sodium Channel Pan Antibody in Immunocytochemistry (ICC/IF)

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Sodium Channel Pan Antibody (PA5-104465) in ICC/IF

Immunocytochemistry analysis of Sodium Channel Pan in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Sodium Channel Pan polyclonal antibody (Product # PA5-104465) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFlu... View More

Sodium Channel Pan Antibody in Western Blot (WB)

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Product Details

PA5-104465

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

Immunohistochemistry (IHC)

1:50-1:200

Immunocytochemistry (ICC/IF)

1:100-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SCN1A(Accession P35498), corresponding to amino acid residues F1486-D1536.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2853766

Product Specific Information

Antibody detects endogenous levels of total pan Sodium Channel.

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-Feb; alternative product; ataxia 3; brain III voltage-gated sodium channel; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CTC-264K15.6; HBSC II; hH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; mH1; Mu-1; Na+ channel; NaCh6; NaN; Neuroendocrine sodium channel; Peripheral nerve protein type 4; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PN1; PN3; PN4; PN5; RIIA sodium channel protein; Sensory neuron sodium channel; Sensory neuron sodium channel 2; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; sodium channel 25; Sodium channel 6; sodium channel alpha-subunit; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain III subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel type X alpha polypeptide; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type 11 alpha polypeptide; sodium channel voltage-gated type 4 alpha polypeptide; sodium channel voltage-gated type I alpha polypeptide; sodium channel voltage-gated type II alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel voltage-gated type V alpha polypeptide; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel voltage-gated type XI alpha polypeptide; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage gated, type XI alpha subunit; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type 11, alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type 3, alpha subunit; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium channel, voltage-gated, type11, alpha polypeptide; SP-19; voltage gated sodium channel; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein

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Gene Aliases: 6430408L10; A230052E19Rik; AI853486; B230332M13; BFIC3; BFIS3; BFNIS; C630029C19Rik; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; dmu; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; Gm1000; HB1; HB2; HBA; HBBD; HBSCI; HBSCII; HH1; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; Kiaa4197; LQT3; MED; mH1; mH2; microI; mKIAA4197; mnd-2; mnd2; Na(v)1.2; Na(V)1.4; Na(V)1.8; NAC1; NAC1A; NAC2; NAC3; NaCh6; NachII; NaN; NaT; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.5c; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nbna1; NCHVS; NE-NA; NENA; nmf2; nmf335; nmf58; NSS2; nur14; PFHB1; PN1; PN3; PN4; PN5; RII/RIIA; RNSCPIIR; SCAL; SCIII; SCN; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; ScpII; seal; SFNP; SkM1; SkM2; SMEI; SNS; SNS-2; SNS2; SSS1; VF1