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Proteintech
Sortilin Monoclonal Antibody (2B11B9)
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FIGURE: 1 / 9
Sortilin Antibody (68007-1-IG150UL) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 68007-1-IG150UL) (Sortilin antibody) at dilution of 1:2,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
68007-1-IG150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2B11B9
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin
Gene Aliases: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Nts3; Ntsr3; SORT1
UniProt ID: (Human) Q99523, (Mouse) Q6PHU5, (Rat) O54861
Entrez Gene ID: (Human) 6272, (Mouse) 20661, (Rat) 83576
ossification
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
multicellular organism development
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
glucose import
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
negative regulation of lipoprotein lipase activity
positive regulation of epithelial cell apoptotic process
transport
cell differentiation
intracellular protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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