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Invitrogen
Spastin Recombinant Rabbit Monoclonal Antibody (RM346)
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Product Details
MA5-27980
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM346
Immunogen
A peptide corresponding to the N-terminus of human Spastin
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2744995
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fidgetin-like 1; KIAA183; SPAST; spastic paraplegia 4 (autosomal dominant; spastin); Spastic paraplegia 4 protein; Spastin
Gene Aliases: ADPSP; FSP2; KIAA1083; SPAST; SPG4
UniProt ID: (Human) Q9UBP0
Entrez Gene ID: (Human) 6683
mitotic cytokinesis
microtubule bundle formation
ER to Golgi vesicle-mediated transport
axonogenesis
anterograde axonal transport
metabolic process
exit from mitosis
axonal transport of mitochondrion
positive regulation of microtubule depolymerization
cytoplasmic microtubule organization
nuclear envelope reassembly
positive regulation of cytokinesis
cytokinetic process
protein hexamerization
microtubule severing
mitotic spindle disassembly
protein homooligomerization
membrane fission
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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