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NeoBiotechnologies
Spastin Monoclonal Antibody (Sp 6C6)
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Product Details
6683-MSM2-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
Sp 6C6
Immunogen
Recombinant full-length human Spastin protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fidgetin-like 1; KIAA183; SPAST; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant; spastin); spastic paraplegia 4 homolog; Spastic paraplegia 4 protein; Spastin; spastin {ECO:0000255|HAMAP-Rule:MF_03021}
Gene Aliases: ADPSP; FSP2; KIAA1083; mKIAA1083; SPAST; SPG4
UniProt ID: (Human) Q9UBP0, (Mouse) Q9QYY8, (Rat) B2RYN7
Entrez Gene ID: (Human) 6683, (Mouse) 50850, (Rat) 362700
microtubule bundle formation
ER to Golgi vesicle-mediated transport
cell cycle
multicellular organism development
nervous system development
metabolic process
cell differentiation
cytoplasmic microtubule organization
positive regulation of cytokinesis
protein hexamerization
microtubule severing
protein homooligomerization
cell division
axonogenesis
positive regulation of microtubule depolymerization
mitotic cytokinesis
anterograde axonal transport
exit from mitosis
axonal transport of mitochondrion
nuclear envelope reassembly
cytokinetic process
mitotic spindle disassembly
membrane fission
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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