Proteintech

Spermidine synthase Polyclonal Antibody

Spermidine synthase Antibody in Immunocytochemistry (ICC/IF)

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Spermidine synthase Antibody (19858-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 19858-1-AP (Spermidine synthase antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Spermidine synthase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Spermidine synthase Antibody in Western Blot (WB)

Spermidine synthase Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19858-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Spermidine synthase Fusion Protein Ag13936 (1-302 aa encoded by BC000309)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEPGPDGPA ASGPAAIREG WFRETCSLWP GQALSLQVEQ LLHHRRSRYQ DILVFRSKTY GNVLVLDGVI QCTERDEFSY QEMIANLPLC SHPNPRKVLI IGGGDGGVLR EVVKHPSVES VVQCEIDEDV IQVSKKFLPG MAIGYSSSKL TLHVGDGFEF MKQNQDAFDV IITDSSDPMG PAESLFKESY YQLMKTALKE DGVLCCQGEC QWLHLDLIKE MRQFCQSLFP VVAYAYCTIP TYPSGQIGFM LCSKNPSTNF QEPVQPLTQQ QVAQMQLKYY NSDVHRAAFV LPEFARKALN DVS (1-302 aa encoded by BC000309)

Target Information

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. SRM synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4.

Translational pediatrics

Li C,Zhang W,Chang X,Di X,Xie Q,Lin B,Zhang H,Ye Z,Lan M,Lian J,Zhang H,Qiu X,Zeng J,Huang M

Tue Feb 28 00:00:00 UTC 2023

A search for acrolein scavengers among food components.

Amino acids

Uemura T,Uchida M,Nakamura M,Shimekake M,Sakamoto A,Terui Y,Higashi K,Ishii I,Kashiwagi K,Igarashi K

Sat Apr 01 00:00:00 UTC 2023

Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Biology of reproduction

Halloran KM,Stenhouse C,Moses RM,Seo H,Johnson GA,Wu G,Bazer FW

Tue May 17 00:00:00 UTC 2022

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.

The Journal of clinical investigation

Sandusky-Beltran LA,Kovalenko A,Placides DS,Ratnasamy K,Ma C,Hunt JB,Liang H,Calahatian JIT,Michalski C,Fahnestock M,Blair LJ,Darling AL,Baker JD,Fontaine SN,Dickey CA,Gamsby JJ,Nash KR,Abner E,Selenica MB,Lee DC

Mon Feb 15 00:00:00 UTC 2021

The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.

American journal of physiology. Cell physiology

Tabbaa M,Ruz Gomez T,Campelj DG,Gregorevic P,Hayes A,Goodman CA

Tue Jun 01 00:00:00 UTC 2021

Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.

Heliyon

Uemura T,Akasaka Y,Ikegaya H

Tue Sep 01 00:00:00 UTC 2020

Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.

Journal of proteomics

Ohira T,Ino Y,Nakai Y,Morita H,Kimura A,Kurata Y,Kagawa H,Kimura M,Egashira K,Moriya S,Hiramatsu K,Kawakita M,Kimura Y,Hirano H

Wed Apr 15 00:00:00 UTC 2020

The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer.

Cancer science

Urabe F,Kosaka N,Sawa Y,Ito K,Kimura T,Egawa S,Ochiya T,Yamamoto Y

Tue Sep 01 00:00:00 UTC 2020

Polyamine Homeostasis in Snyder-Robinson Syndrome.

Medical sciences (Basel, Switzerland)

Murray-Stewart T,Dunworth M,Foley JR,Schwartz CE,Casero RA

Fri Dec 07 00:00:00 UTC 2018

Polyamine Homeostasis in Snyder-Robinson Syndrome.

Medical sciences (Basel, Switzerland)

Murray-Stewart T,Dunworth M,Foley JR,Schwartz CE,Casero RA

Fri Dec 07 00:00:00 UTC 2018

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.

Nature communications

Miao H,Ou J,Peng Y,Zhang X,Chen Y,Hao L,Xie G,Wang Z,Pang X,Ruan Z,Li J,Yu L,Xue B,Shi H,Shi C,Liang H

Wed May 18 00:00:00 UTC 2016

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.

Nature communications

Miao H,Ou J,Peng Y,Zhang X,Chen Y,Hao L,Xie G,Wang Z,Pang X,Ruan Z,Li J,Yu L,Xue B,Shi H,Shi C,Liang H

Wed May 18 00:00:00 UTC 2016

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.

Nature communications

Miao H,Ou J,Peng Y,Zhang X,Chen Y,Hao L,Xie G,Wang Z,Pang X,Ruan Z,Li J,Yu L,Xue B,Shi H,Shi C,Liang H

Wed May 18 00:00:00 UTC 2016

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.

Nature communications

Miao H,Ou J,Peng Y,Zhang X,Chen Y,Hao L,Xie G,Wang Z,Pang X,Ruan Z,Li J,Yu L,Xue B,Shi H,Shi C,Liang H

Wed May 18 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Putrescine aminopropyltransferase; SPDSY; Spermidine synthase; spermidine synthase-1

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Gene Aliases: AA407669; PAPT; SpdST; SPDSY; SPS1; SRM; SRML1

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UniProt ID: (Human) P19623, (Mouse) Q64674

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Entrez Gene ID: (Human) 6723, (Mouse) 20810, (Rat) 84596

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Function(s)

spermidine synthase activity protein binding protein homodimerization activity catalytic activity transferase activity

Process(es)

polyamine metabolic process spermidine biosynthetic process polyamine biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Spermidine synthase Polyclonal Antibody

Spermidine synthase Antibody (19858-1-AP) in ICC/IF

Product Details

19858-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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