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Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6) Monoclonal Antibody (1), FITC
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Product Details
X1626M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1
Immunogen
Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Epitope for the antibody is the C-terminal of the EDG6 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody.
Target Information
EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDG-6; Endothelial differentiation G-protein coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6; S1P receptor 4; S1P receptor Edg-6; S1P(4) receptor; Sphingosine 1-phosphate receptor 4; Sphingosine 1-phosphate receptor Edg-6
Gene Aliases: EDG6; LPC1; S1P4; S1PR4; SLP4
UniProt ID: (Human) O95977
Entrez Gene ID: (Human) 8698
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