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NeoBiotechnologies
StAR (Steroidogenic Acute Regulator) Monoclonal Antibody (STAR, 2154)
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Product Details
6770-MSM4-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
STAR, 2154
Immunogen
Recombinant fragment (around aa 39-108) of human STAR protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cholesterol trafficker; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP
Gene Aliases: STAR; STARD1
UniProt ID: (Human) P49675
Entrez Gene ID: (Human) 6770
steroid biosynthetic process
bile acid biosynthetic process
C21-steroid hormone biosynthetic process
progesterone biosynthetic process
estrogen biosynthetic process
brain development
response to nutrient
cholesterol metabolic process
glucocorticoid metabolic process
male gonad development
response to herbicide
response to ionizing radiation
response to lead ion
positive regulation of gene expression
response to activity
diterpenoid metabolic process
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
intracellular cholesterol transport
cellular response to insulin stimulus
response to nicotine
cellular response to interferon-alpha
response to drug
response to hydrogen peroxide
circadian sleep/wake cycle, REM sleep
negative regulation of neuron apoptotic process
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
regulation of neuronal synaptic plasticity
positive regulation of neurogenesis
response to corticosterone
response to fungicide
testosterone biosynthetic process
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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