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Rockland
Stat1 Polyclonal Antibody
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Product Details
600-401-A42
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Stat1 protein.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for mouse Stat1 protein. A BLAST analysis was used to suggest cross-reactivity with Stat1 from mouse and rat based on 100% homology with the immunizing sequence. Partial reactivity is expected against Stat1 from human sources as 90% homology is noted. Cross-reactivity with Stat1 from other sources has not been determined.
Target Information
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686B04100; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1-alpha/beta; STAT; STAT 1; STAT-1; stat1 alpha
Gene Aliases: 2010005J02Rik; AA408197; DD6G4-4
Entrez Gene ID: (Mouse) 20846, (Rat) 25124
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
tumor necrosis factor receptor binding
protein binding
enzyme binding
CCR5 chemokine receptor binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
protein phosphatase 2A binding
negative regulation of endothelial cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
JAK-STAT cascade
response to nutrient
blood circulation
positive regulation of cell proliferation
response to mechanical stimulus
response to bacterium
negative regulation of angiogenesis
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
cellular response to insulin stimulus
tumor necrosis factor-mediated signaling pathway
response to cytokine
negative regulation of macrophage fusion
cellular response to interferon-beta
response to drug
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
response to peptide hormone
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
response to cAMP
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
renal tubule development
cellular response to lipopolysaccharide
regulation of transcription from RNA polymerase II promoter
response to organic cyclic compound
response to hydrogen peroxide
endothelial cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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