Invitrogen

Streptococcus pneumoniae Polyclonal Antibody

Streptococcus pneumoniae Antibody in Immunohistochemistry (IHC)

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Streptococcus pneumoniae Antibody (PA1-7259) in IHC

Annals of neurology 2021 - 1 FIGURE Validation of a rat model of acute bacterial meningitis infection by Streptococcus pneumoniae . (A) Schematic representation of the experimental procedure. (B) Change in body weight of infected and control rats 24 hours after subarachnoid injection of S pneumoniae strain SP001 as a percentage of baseline body weight (unpaired t -test, ** p = 0.0017, n = 11 in each group, mean +- standard de... View More

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Product Details

PA1-7259

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Bacteria

Published species

Bacteria

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Whole cell blend of numerous serotypes.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4-5 mg/mL

Purification

IgG fraction

Storage buffer

PBS, pH 7.2

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_1087585

Product Specific Information

PA1-7259 detects Streptococcus pneumoniae. This product cross-reacts with types 3, 4, 6, 7, 9, 14, 18, 19 and 23. The antiserum was not absorbed and may react with related microorganisms.

PA1-7259 has been successfully used in immunofluorescence and ELISA procedures.

The PA1-7259 immunogen is a whole cell blend of numerous serotypes.

Short term storage, up to 6 months, is liquid at 4ºC. For long term storage, aliquot and store at -20 ºC.

Target Information

There are more than 85 antigenic types of S. pneumoniae, which are determined by capsule antigens. Altough S. pneumoniae is part of the normal respiratory flora, invasion commonly results in pneumonia as well as meningitis. S. pneumoniae is protected from phagocytosis by its polysaccharide capsule which is also a prominent virulence factor. Infections can usually be treated with antibiotics, although resistant strains are emerging.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A multiple comorbidities mouse lung infection model in ApoE‑deficient mice.

Biomedical reports

Bartlett B,Lee S,Ludewick HP,Siew T,Verma S,Waterer G,Corrales-Medina VF,Dwivedi G

PA1-7259 was used in ELISA to study respiratory and systemic inflammation that results from pneumonia in the setting of atherosclerosis.

Wed Mar 01 00:00:00 UTC 2023

Clostridia and Enteroviruses as Synergistic Triggers of Type 1 Diabetes Mellitus.

International journal of molecular sciences

Root-Bernstein R,Chiles K,Huber J,Ziehl A,Turke M,Pietrowicz M

PA1-7259 was used in ELISA to suggest that type 1 diabetes mellitus T1DM is triggered by combined enterovirus-Clostridium (and possibly combined Epstein-Barr-virus-Streptococcal) infections, and the probable rate of such co-infections approximates the rate of new T1DM diagnoses.

Sat May 06 00:00:00 UTC 2023

SARS-CoV-2 and Its Bacterial Co- or Super-Infections Synergize to Trigger COVID-19 Autoimmune Cardiopathies.

International journal of molecular sciences

Root-Bernstein R,Huber J,Ziehl A,Pietrowicz M

PA1-7259 was used in ELISA to suggest that AC results from SARS-CoV-2 infections or vaccination complicated by bacterial infections.

Sat Jul 29 00:00:00 UTC 2023

DNase Treatment Prevents Cerebrospinal Fluid Block in Early Experimental Pneumococcal Meningitis.

Annals of neurology

Pavan C,L R Xavier A,Ramos M,Fisher J,Kritsilis M,Linder A,Bentzer P,Nedergaard M,Lundgaard I

PA1-7259 was used in Immunohistochemistry (PFA) to suggest that CSF accumulation is responsible for cerebral edema formation and identify the glymphatic system and NETs as possible new treatment targets in S pneumoniae meningitis.

Fri Oct 01 00:00:00 UTC 2021

DNase Treatment Prevents Cerebrospinal Fluid Block in Early Experimental Pneumococcal Meningitis.

Annals of neurology

Pavan C,L R Xavier A,Ramos M,Fisher J,Kritsilis M,Linder A,Bentzer P,Nedergaard M,Lundgaard I

Fri Oct 01 00:00:00 UTC 2021

Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis.

Nature communications

Mohanty T,Fisher J,Bakochi A,Neumann A,Cardoso JFP,Karlsson CAQ,Pavan C,Lundgaard I,Nilson B,Reinstrup P,Bonnevier J,Cederberg D,Malmström J,Bentzer P,Linder A

PA1-7259 was used in Immunohistochemistry to show neutrophil extracellular traps in the cerebrospinal fluid of patients with pneumococcal meningitis and their absence in other forms of meningitis with neutrophil influx.

Wed Apr 10 00:00:00 UTC 2019

Disposable amperometric magnetoimmunosensors for the specific detection of Streptococcus pneumoniae.

Biosensors & bioelectronics

Campuzano S,de Ávila BE,Yuste J,Pedrero M,García JL,García P,García E,Pingarrón JM

PA1-7259 was used in flow cytometry to develop a new amperometric magnetoimmunosenso methodology for the quantification of Streptococcus pneumoniae

Wed Dec 15 00:00:00 UTC 2010

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