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Rockland
Sts-1 Polyclonal Antibody
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FIGURE: 1 / 2
Sts-1 Antibody (600-401-870) in IHC (P)
Immunohistochemistry with anti-Sts-1 antibody showing Sts-1 staining of histiocytic elements in cytoplasm of human tonsil at 20x and 40x (B & C). Formalin fixed/paraffin embedded sections were subjected to heat induced epitope retrieval (HIER) at pH 6.2 and then incubated with rabbit anti-Sts-1 antibody at 4.0 µg/ml for 60 minutes. The reaction was developed using MACH 1 universal HRP polymer detection syst... View More
Product Details
600-401-870
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1.
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against mouse Sts-1 protein. A BLAST analysis was used to suggest reactivity with this protein from mouse, human, rat and dog based on 100% homology for the immunogen sequence. Cross reactivity with Sts-1 homologues from other sources has not been determined.
Target Information
Sts1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbl-interacting protein p70; MGC15437; STS-1; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2; Ubiquitin-associated and SH3 domain-containing protein B
Gene Aliases: 2810457I06Rik; BB125008; p70; Sts1; TULA-2; Ubash3b
UniProt ID: (Mouse) Q8BGG7
Entrez Gene ID: (Mouse) 72828
negative regulation of protein kinase activity
negative regulation of signal transduction
peptidyl-tyrosine dephosphorylation
negative regulation of osteoclast differentiation
negative regulation of bone resorption
regulation of release of sequestered calcium ion into cytosol
negative regulation of platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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