Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
NE152-PAB
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Bovine Superoxide dismutase
Conjugate
Form
Lyophilized
Concentration
2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.5% dextran
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstituted by adding 0.5 mL sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20°C.
Cross-reactivities against enzymes of other sources may occur but have not been determined.
Prior to use, an aliquot is thawed slowly at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used t he same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the product.
Target Information
SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Amyotrophic lateral sclerosis 1 (ALS1); Cu-Zn superoxide dismutase; Cu/Zn SOD; HGNC:11179; Indophenoloxidase A (IPOA); superoxide dismutase; Superoxide Dismutase 1 (SOD1); Superoxide dismutase [Cu-Zn]
Gene Aliases: BOS_506; SOD1; SOD1L1
UniProt ID: (Bovine) P00442
Entrez Gene ID: (Bovine) 281495
activation of MAPK activity
protein polyubiquitination
response to superoxide
ovarian follicle development
regulation of cytokine production
positive regulation of cytokine production
retina homeostasis
myeloid cell homeostasis
double-strand break repair
apoptotic DNA fragmentation
glutathione metabolic process
superoxide metabolic process
cellular iron ion homeostasis
spermatogenesis
embryo implantation
cell aging
sensory perception of sound
locomotory behavior
regulation of blood pressure
response to heat
response to organic substance
transmission of nerve impulse
removal of superoxide radicals
peripheral nervous system myelin maintenance
regulation of multicellular organism growth
response to drug
response to hydrogen peroxide
positive regulation of catalytic activity
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of neuron apoptotic process
interspecies interaction between organisms
response to ethanol
negative regulation of cholesterol biosynthetic process
regulation of protein kinase activity
muscle cell cellular homeostasis
response to axon injury
hydrogen peroxide biosynthetic process
positive regulation of nitric-oxide synthase biosynthetic process
regulation of mitochondrial membrane potential
heart contraction
neurofilament cytoskeleton organization
relaxation of vascular smooth muscle
auditory receptor cell stereocilium organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support