Active Motif

Suz12 Polyclonal Antibody

FIGURE: 1 / 3

Suz12 Antibody (39357) in WB

Suz12 antibody (pAb) tested by Western blot. HeLa cell nuclear extract (25 µg) was probed with Suz12 pAb (1:500 dilution).

Suz12 Antibody in ChIP-Sequencing (ChIP-Seq)

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Product Details

39357

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250-1:1,000

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

ChIP assay (ChIP)

10 µL

View 1 publication 1 publication

ChIP-sequencing (ChIP-Seq)

10 µL

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This Suz12 antibody was raised against a peptide corresponding to the C-terminus of human Suz12.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.5, with 30% glycerol

Contains

0.035% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2614929

Target Information

SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.

Cancer cell

Erkek S,Johann PD,Finetti MA,Drosos Y,Chou HC,Zapatka M,Sturm D,Jones DTW,Korshunov A,Rhyzova M,Wolf S,Mallm JP,Beck K,Witt O,Kulozik AE,Frühwald MC,Northcott PA,Korbel JO,Lichter P,Eils R,Gajjar A,Roberts CWM,Williamson D,Hasselblatt M,Chavez L,Pfister SM,Kool M

Research topic: atypical teratoid rhabdoid tumors (ATRT), Gene Regulation

Mon Jan 14 00:00:00 UTC 2019

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection.

PLoS pathogens

Toth Z,Papp B,Brulois K,Choi YJ,Gao SJ,Jung JU

Research topic: HIV & AIDS

Thu Sep 01 00:00:00 UTC 2016

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection.

PLoS pathogens

Toth Z,Papp B,Brulois K,Choi YJ,Gao SJ,Jung JU

Research topic: HIV & AIDS

Thu Sep 01 00:00:00 UTC 2016

Retinoic acid controls body axis extension by directly repressing Fgf8 transcription.

Development (Cambridge, England)

Kumar S,Duester G

Research topic: Embryogenesis

Fri Aug 01 00:00:00 UTC 2014

In situ histone landscape of nephrogenesis.

Epigenetics

McLaughlin N,Wang F,Saifudeen Z,El-Dahr SS

Research topic: Nephrogenesis

Sat Feb 01 00:00:00 UTC 2014

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.

Cancer cell

Bender S,Tang Y,Lindroth AM,Hovestadt V,Jones DT,Kool M,Zapatka M,Northcott PA,Sturm D,Wang W,Radlwimmer B,Højfeldt JW,Truffaux N,Castel D,Schubert S,Ryzhova M,Seker-Cin H,Gronych J,Johann PD,Stark S,Meyer J,Milde T,Schuhmann M,Ebinger M,Monoranu CM,Ponnuswami A,Chen S,Jones C,Witt O,Collins VP,von Deimling A,Jabado N,Puget S,Grill J,Helin K,Korshunov A,Lichter P,Monje M,Plass C,Cho YJ,Pfister SM

Research topic: Glioma

Mon Nov 11 00:00:00 UTC 2013

Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells.

PLoS pathogens

Rossetto CC,Tarrant-Elorza M,Pari GS

Research topic: Innate Immunity

Mon Dec 09 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog

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Gene Aliases: 2610028O16Rik; AI195385; AU016842; AW536442; CHET9; D11Ertd530e; JJAZ1; KIAA0160; mKIAA0160; SUZ12

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UniProt ID: (Human) Q15022, (Mouse) Q80U70

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Entrez Gene ID: (Human) 23512, (Mouse) 52615

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Function(s)

RNA polymerase II core promoter sequence-specific DNA binding RNA binding protein binding chromatin DNA binding methylated histone binding histone methyltransferase activity metal ion binding chromatin binding sequence-specific DNA binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation chromatin modification histone methylation histone ubiquitination negative regulation of chemokine production negative regulation of tyrosine phosphorylation of Stat3 protein negative regulation of cell differentiation negative regulation of epithelial cell proliferation histone H3-K27 trimethylation negative regulation of gene expression, epigenetic

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Suz12 Polyclonal Antibody

Suz12 Antibody (39357) in WB

Product Details

39357

Western Blot (WB)

Immunocytochemistry (ICC/IF)

ChIP assay (ChIP)

ChIP-sequencing (ChIP-Seq)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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