Product References
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1.
Brain : a journal of neurology
Chalkiadaki K,Hooshmandi M,Lach G,Statoulla E,Simbriger K,Amorim IS,Kouloulia S,Zafeiri M,Pothos P,Bonneil É,Gantois I,Popic J,Kim SH,Wong C,Cao R,Komiyama NH,Atlasi Y,Jafarnejad SM,Khoutorsky A,Gkogkas CG
PA1-046 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation to identify the synaptic Ras GTPase activating protein 1 (Syngap1), encoded by a syndromic autism gene, as a downstream target of Mnk1 since Syngap1 immunoprecipitated with Mnk1 and showed reduced phosphorylation (S788) in Mnk DKO mice.
Tue May 02 00:00:00 UTC 2023
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1.
Brain : a journal of neurology
Chalkiadaki K,Hooshmandi M,Lach G,Statoulla E,Simbriger K,Amorim IS,Kouloulia S,Zafeiri M,Pothos P,Bonneil É,Gantois I,Popic J,Kim SH,Wong C,Cao R,Komiyama NH,Atlasi Y,Jafarnejad SM,Khoutorsky A,Gkogkas CG
PA1-046 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation to identify the synaptic Ras GTPase activating protein 1 (Syngap1), encoded by a syndromic autism gene, as a downstream target of Mnk1 since Syngap1 immunoprecipitated with Mnk1 and showed reduced phosphorylation (S788) in Mnk DKO mice.
Tue May 02 00:00:00 UTC 2023
Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
Nature communications
Kim H,Kim D,Cho Y,Kim K,Roh JD,Kim Y,Yang E,Kim SS,Ahn S,Kim H,Kang H,Bae Y,Kim E
PA1-046 was used in Immuno-assay to suggest that chronic modulation of serotonergic receptors during critical early postnatal periods prevents synaptic and behavioral deficits in adult Arid1b+/- mice through transcriptional reprogramming.
Sat Aug 27 00:00:00 UTC 2022
SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain.
Journal of neurochemistry
Gou G,Roca-Fernandez A,Kilinc M,Serrano E,Reig-Viader R,Araki Y,Huganir RL,de Quintana-Schmidt C,Rumbaugh G,Bayés À
PA1-046 was used in Western Blotting to hypothesize that different SynGAP isoforms will mediate different sets of functions and that deciphering their spatio-temporal expression and subcellular localization will accelerate understanding their multiple functions.
Tue Sep 01 00:00:00 UTC 2020
Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.
Frontiers in synaptic neuroscience
Sahasrabudhe A,Begum F,Guevara CA,Morrison C,Hsiao K,Kezunovic N,Bozdagi-Gunal O,Benson DL
PA1-046 was used in Immunohistochemistry and Western Blotting to examine how Cyfip1 haploinsufficiency impacts SynGAP1 levels and localization, as well as potential sites for mechanistic interaction in mouse hippocampus.
Wed Feb 24 00:00:00 UTC 2021
Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.
Frontiers in synaptic neuroscience
Sahasrabudhe A,Begum F,Guevara CA,Morrison C,Hsiao K,Kezunovic N,Bozdagi-Gunal O,Benson DL
PA1-046 was used in Immunohistochemistry and Western Blotting to examine how Cyfip1 haploinsufficiency impacts SynGAP1 levels and localization, as well as potential sites for mechanistic interaction in mouse hippocampus.
Wed Feb 24 00:00:00 UTC 2021
Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.
Frontiers in synaptic neuroscience
Sahasrabudhe A,Begum F,Guevara CA,Morrison C,Hsiao K,Kezunovic N,Bozdagi-Gunal O,Benson DL
PA1-046 was used in Immunohistochemistry and Western Blotting to examine how Cyfip1 haploinsufficiency impacts SynGAP1 levels and localization, as well as potential sites for mechanistic interaction in mouse hippocampus.
Wed Feb 24 00:00:00 UTC 2021
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
eLife
Mastro TL,Preza A,Basu S,Chattarji S,Till SM,Kind PC,Kennedy MB
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Western Blot
Wed Jan 15 00:00:00 UTC 2020
Dynamic- and Frequency-Specific Regulation of Sleep Oscillations by Cortical Potassium Channels.
Current biology : CB
Muheim CM,Spinnler A,Sartorius T,Dürr R,Huber R,Kabagema C,Ruth P,Brown SA
PA1-046 was used in Immunohistochemistry to postulate that additive dynamic roles of individual potassium channels could integrate different influences upon sleep and wake within single neurons.
Mon Sep 23 00:00:00 UTC 2019
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
iScience
Li L,Fan Y,Huang X,Luo J,Zhong L,Shu XS,Lu L,Xiang T,Chan ATC,Yeo W,Chen C,Chan WY,Huganir RL,Tao Q
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Immunocytochemistry
Fri Nov 22 00:00:00 UTC 2019
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
iScience
Li L,Fan Y,Huang X,Luo J,Zhong L,Shu XS,Lu L,Xiang T,Chan ATC,Yeo W,Chen C,Chan WY,Huganir RL,Tao Q
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Immunocytochemistry
Fri Nov 22 00:00:00 UTC 2019
Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior.
eLife
Creson TK,Rojas C,Hwaun E,Vaissiere T,Kilinc M,Jimenez-Gomez A,Holder JL,Tang J,Colgin LL,Miller CA,Rumbaugh G
PA1-046 was used in Western Blotting to determine if SYNGAP1 retains therapeutically-relevant biological functions into adulthood.
Fri Apr 26 00:00:00 UTC 2019
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density.
eLife
Walkup WG,Mastro TL,Schenker LT,Vielmetter J,Hu R,Iancu A,Reghunathan M,Bannon BD,Kennedy MB
PA1-046 was used in western blot demonstrate that synGAP-alpha1 regulates postsynaptic density composition by restricting binding to the PDZ domains of PSD-95
Tue Sep 13 00:00:00 UTC 2016
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density.
eLife
Walkup WG,Mastro TL,Schenker LT,Vielmetter J,Hu R,Iancu A,Reghunathan M,Bannon BD,Kennedy MB
PA1-046 was used in western blot demonstrate that synGAP-alpha1 regulates postsynaptic density composition by restricting binding to the PDZ domains of PSD-95
Tue Sep 13 00:00:00 UTC 2016
The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
Nature communications
Reinhard JR,Kriz A,Galic M,Angliker N,Rajalu M,Vogt KE,Ruegg MA
PA1-046 was used in western blot to determine regulation of spine structural plasticity and memory and learning by the calcium sensor Copine-6
Thu May 19 00:00:00 UTC 2016
Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly.
Biological psychiatry
Aceti M,Creson TK,Vaissiere T,Rojas C,Huang WC,Wang YX,Petralia RS,Page DT,Miller CA,Rumbaugh G
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Western Blot
Fri May 01 00:00:00 UTC 2015
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ferreira JS,Schmidt J,Rio P,Águas R,Rooyakkers A,Li KW,Smit AB,Craig AM,Carvalho AL
PA1-046 was used in immunocytochemistry and western blot to assess the role of the GluN2B subunit during development and in synaptic plasticity
Wed Jun 03 00:00:00 UTC 2015
Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
The Journal of comparative neurology
Friedman LG,Riemslagh FW,Sullivan JM,Mesias R,Williams FM,Huntley GW,Benson DL
PA1-046 was used in immunohistochemistry to examine the progression of functional corticostriatal interactions
Thu Jan 01 00:00:00 UTC 2015
Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
The Journal of comparative neurology
Friedman LG,Riemslagh FW,Sullivan JM,Mesias R,Williams FM,Huntley GW,Benson DL
PA1-046 was used in immunohistochemistry to examine the progression of functional corticostriatal interactions
Thu Jan 01 00:00:00 UTC 2015
Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
The Journal of biological chemistry
Walkup WG,Washburn L,Sweredoski MJ,Carlisle HJ,Graham RL,Hess S,Kennedy MB
PA1-046 was used in immunoprecipitation and western blot to study the effect of phosphorylation on synGAP activity
Fri Feb 20 00:00:00 UTC 2015
Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
The Journal of biological chemistry
Walkup WG,Washburn L,Sweredoski MJ,Carlisle HJ,Graham RL,Hess S,Kennedy MB
PA1-046 was used in immunoprecipitation and western blot to study the effect of phosphorylation on synGAP activity
Fri Feb 20 00:00:00 UTC 2015
Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.
Neuron
Ozkan ED,Creson TK,Kramár EA,Rojas C,Seese RR,Babyan AH,Shi Y,Lucero R,Xu X,Noebels JL,Miller CA,Lynch G,Rumbaugh G
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Western Blot
Wed Jun 18 00:00:00 UTC 2014
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.
Molecular brain
Nagura H,Ishikawa Y,Kobayashi K,Takao K,Tanaka T,Nishikawa K,Tamura H,Shiosaka S,Suzuki H,Miyakawa T,Fujiyoshi Y,Doi T
PA1-046 was used in western blot to use knock-in mice expressing PSD-95 lacking PDZ1/PDZ2 ligand binding to study the role of PSD-95 in the synaptic clustering of postsynaptic density proteins, synaptic transmission and memory
Wed Dec 26 00:00:00 UTC 2012
Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Carlisle HJ,Luong TN,Medina-Marino A,Schenker L,Khorosheva E,Indersmitten T,Gunapala KM,Steele AD,O'Dell TJ,Patterson PH,Kennedy MB
PA1-046 was used in western blot to investigate the role of densin-180 in the organization and dynamics of postsynaptic signaling complexes
Wed Nov 09 00:00:00 UTC 2011
Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.
The Journal of biological chemistry
Ferreira JS,Rooyakkers A,She K,Ribeiro L,Carvalho AL,Craig AM
PA1-046 was used in Immunocytochemistry to indicate that the major mechanisms mediating homeostatic synaptic accumulation and protein kinase C (PKC) dispersal of NMDA receptors occur independently of GluN1 splice isoform.
Fri Aug 12 00:00:00 UTC 2011
Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.
The Journal of biological chemistry
Ferreira JS,Rooyakkers A,She K,Ribeiro L,Carvalho AL,Craig AM
PA1-046 was used in Immunocytochemistry to indicate that the major mechanisms mediating homeostatic synaptic accumulation and protein kinase C (PKC) dispersal of NMDA receptors occur independently of GluN1 splice isoform.
Fri Aug 12 00:00:00 UTC 2011
Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling.
Proceedings of the National Academy of Sciences of the United States of America
McClelland AC,Hruska M,Coenen AJ,Henkemeyer M,Dalva MB
PA1-046 was used in immunocytochemistry to investigate the mechanism of excitatory synapse density modulation by EphB2-ephrin-B3 association
Tue May 11 00:00:00 UTC 2010
In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Delint-Ramirez I,Fernández E,Bayés A,Kicsi E,Komiyama NH,Grant SG
PA1-046 was used in western blot to investigate the composition of NMDAR-PSD-95 complexes in lipid rafts
Wed Jun 16 00:00:00 UTC 2010
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.
Human molecular genetics
Marcora E,Kennedy MB
Published figure using SynGAP polyclonal antibody (Product # PA1-046) in Western Blot
Mon Nov 15 00:00:00 UTC 2010
Age-related accumulation of Reelin in amyloid-like deposits.
Neurobiology of aging
Knuesel I,Nyffeler M,Mormède C,Muhia M,Meyer U,Pietropaolo S,Yee BK,Pryce CR,LaFerla FM,Marighetto A,Feldon J
PA1-046 was used in immunocytochemistry to examine the Reelin accumulation of Reelin in amyloid-like deposits during ageing
Fri May 01 00:00:00 UTC 2009
Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons.
The Journal of comparative neurology
Harms KJ,Craig AM
PA1-046 was used in immunocytochemistry to study the effect of activity on synapse composition and organization in central nerve system
Mon Sep 12 00:00:00 UTC 2005
Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lévi S,Logan SM,Tovar KR,Craig AM
PA1-046 was used in immunocytochemistry to study the GABAergic synaptic phenotype of hippocampal neurons from gephyrin-/- mice.
Wed Jan 07 00:00:00 UTC 2004
Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II.
The Journal of biological chemistry
Oh JS,Manzerra P,Kennedy MB
PA1-046 was used in western blot to investigate the role of calcium/calmodulin-dependent protein kinase II in regulating synGAP.
Fri Apr 23 00:00:00 UTC 2004
Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lévi S,Grady RM,Henry MD,Campbell KP,Sanes JR,Craig AM
PA1-046 was used in immunocytochemistry to investigate the functions of dystrophin glycoprotein complex in the differentiation of synapses
Sat Jun 01 00:00:00 UTC 2002
A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.
Neuron
Chen HJ,Rojas-Soto M,Oguni A,Kennedy MB
PA1-046 was used in western blot to characterize a synaptic Ras-GTPase activating protein in the brain
Fri May 01 00:00:00 UTC 1998
