Proteintech

Synaptophysin Monoclonal Antibody (4E12C4)

Synaptophysin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Synaptophysin Antibody (67864-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67864-1-Ig (Synaptophysin antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Synaptophysin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

67864-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4E12C4

Immunogen

Synaptophysin; SYP Fusion Protein Ag11803

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Protective Effect of 20(S)-Protopanaxadiol on D-Gal-Induced Cognitively Impaired Mice Based on Its Target Protein Brain-type Creatine Kinase.

Journal of agricultural and food chemistry

Zhang H,Chen F,Xu S,Zhang W,Li R,Yao Q,Zhao Y,Zhu Z,Chen L

Wed Feb 08 00:00:00 UTC 2023

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Chen XQ,Zuo X,Becker A,Head E,Mobley WC

Mon May 01 00:00:00 UTC 2023

A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.

BMC complementary medicine and therapies

Meng P,Zhang X,Liu TT,Liu J,Luo Y,Xie MX,Yang H,Fang R,Guo DW,Zhong ZY,Wang YH,Ge JW

Thu Jun 15 00:00:00 UTC 2023

Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.

Neurochemistry international

Feng Y,Yang L,Ma X,Huang Z,Zong X,Citadin CT,Lin HW,Zhang Q

Sun Jan 01 00:00:00 UTC 2023

Expression of SH3 and Multiple Ankyrin Repeat Domains Protein 3 in Mouse Retina.

Frontiers in cellular neuroscience

Xu Y,Wang Y,Tong G,Li L,Cheng J,Zhang L,Xu Q,Wang L,Zhang P

Wed Apr 13 00:00:00 UTC 2022

The role of reelin in the pathological mechanism of depression from clinical to rodents.

Psychiatry research

Jin K,Zhang S,Jiang C,Liu R,Chen B,Zhao H,Zhang Q,Shen Z,Xu P,Hu X,Jiao J,Lu J,Huang M

Tue Nov 01 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I

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Gene Aliases: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1

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UniProt ID: (Human) P08247, (Rat) P07825, (Mouse) Q62277

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Entrez Gene ID: (Human) 6855, (Rat) 24804, (Mouse) 20977

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Function(s)

transporter activity cholesterol binding SH2 domain binding identical protein binding protein self-association protein binding syntaxin-1 binding protein domain specific binding protein complex binding

Process(es)

endocytosis regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity cellular response to organic substance regulation of opioid receptor signaling pathway synaptic vesicle maturation synaptic vesicle membrane organization transport chemical synaptic transmission

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Synaptophysin Monoclonal Antibody (4E12C4)

Synaptophysin Antibody (67864-1-IG) in IHC (P)

Product Details

67864-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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