Proteintech

Syntaxin 11 Polyclonal Antibody

Syntaxin 11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Syntaxin 11 Antibody (13301-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using (Product # 13301-1-AP) (Syntaxin 11 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Syntaxin 11 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

13301-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Syntaxin 11 Fusion Protein Ag4097 (1-287 aa encoded by BC033519)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKDRLAELL DLSKQYDQQF PDGDDEFDSP HEDIVFETDH ILESLYRDIR DIQDENQLLV ADVKRLGKQN ARFLTSMRRL SSIKRDTNSI AKAIKARGEV IHCKLRAMKE LSEAAEAQHG PHSAVARISR AQYNALTLTF QRAMHDYNQA EMKQRDNCKI RIQRQLEIMG KEVSGDQIED MFEQGKWDVF SENLLADVKG ARAALNEIES RHRELLRLES RIRDVHELFL QMAVLVEKQA DTLNVIELNV QKTVDYTGQA KAQVRKAVQY EEKNPCRTLC CFCCPCLK (1-287 aa encoded by BC033519)

Target Information

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.

Immunity

Yang M,Jiang H,Ding C,Zhang L,Ding N,Li G,Zhang F,Wang J,Deng L,Liu J,Xu Y

Tue May 09 00:00:00 UTC 2023

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

iScience

Zhang G,Han J,Wang L,Yang X,Yan Z,Qu M,Zhou H,Bilal H,Wang F,Ge H,Yang X

Fri Apr 15 00:00:00 UTC 2022

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

iScience

Zhang G,Han J,Wang L,Yang X,Yan Z,Qu M,Zhou H,Bilal H,Wang F,Ge H,Yang X

Fri Apr 15 00:00:00 UTC 2022

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

iScience

Zhang G,Han J,Wang L,Yang X,Yan Z,Qu M,Zhou H,Bilal H,Wang F,Ge H,Yang X

Fri Apr 15 00:00:00 UTC 2022

The septin cytoskeleton regulates natural killer cell lytic granule release.

The Journal of cell biology

Phatarpekar PV,Overlee BL,Leehan A,Wilton KM,Ham H,Billadeau DD

Mon Nov 02 00:00:00 UTC 2020

The septin cytoskeleton regulates natural killer cell lytic granule release.

The Journal of cell biology

Phatarpekar PV,Overlee BL,Leehan A,Wilton KM,Ham H,Billadeau DD

Mon Nov 02 00:00:00 UTC 2020

The septin cytoskeleton regulates natural killer cell lytic granule release.

The Journal of cell biology

Phatarpekar PV,Overlee BL,Leehan A,Wilton KM,Ham H,Billadeau DD

Mon Nov 02 00:00:00 UTC 2020

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Frontiers in immunology

Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

Fri May 10 00:00:00 UTC 2019

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Frontiers in immunology

Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

Fri May 10 00:00:00 UTC 2019

C2 Domains of Munc13-4 Are Crucial for Ca²⁺-Dependent Degranulation and Cytotoxicity in NK Cells.

Journal of immunology (Baltimore, Md. : 1950)

Bin NR,Ma K,Tien CW,Wang S,Zhu D,Park S,Turlova E,Sugita K,Shirakawa R,van der Sluijs P,Horiuchi H,Sun HS,Monnier PP,Gaisano HY,Sugita S

Sun Jul 15 00:00:00 UTC 2018

C2 Domains of Munc13-4 Are Crucial for Ca²⁺-Dependent Degranulation and Cytotoxicity in NK Cells.

Journal of immunology (Baltimore, Md. : 1950)

Bin NR,Ma K,Tien CW,Wang S,Zhu D,Park S,Turlova E,Sugita K,Shirakawa R,van der Sluijs P,Horiuchi H,Sun HS,Monnier PP,Gaisano HY,Sugita S

Sun Jul 15 00:00:00 UTC 2018

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 UTC 2015

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 UTC 2015

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 UTC 2015

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 UTC 2015

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.

PloS one

Hellewell AL,Foresti O,Gover N,Porter MY,Hewitt EW

Mon Jun 15 00:00:00 UTC 2015

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.

PloS one

Hellewell AL,Foresti O,Gover N,Porter MY,Hewitt EW

Mon Jun 15 00:00:00 UTC 2015

An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2.

Frontiers in immunology

Müller ML,Chiang SC,Meeths M,Tesi B,Entesarian M,Nilsson D,Wood SM,Nordenskjöld M,Henter JI,Naqvi A,Bryceson YT

Tue Jan 14 00:00:00 UTC 2014

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 UTC 2013

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 UTC 2013

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 UTC 2013

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 UTC 2013

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Pediatric blood & cancer

Marsh RA,Satake N,Biroschak J,Jacobs T,Johnson J,Jordan MB,Bleesing JJ,Filipovich AH,Zhang K

Thu Jul 15 00:00:00 UTC 2010

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Pediatric blood & cancer

Marsh RA,Satake N,Biroschak J,Jacobs T,Johnson J,Jordan MB,Bleesing JJ,Filipovich AH,Zhang K

Thu Jul 15 00:00:00 UTC 2010

Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.

Biochemical and biophysical research communications

Kawashima R,Ikematsu K,Abe Y,Sato M,Tsuruya S,Nakasono I,Fukushima H,Inoue K,Tsuboi T

Fri Sep 17 00:00:00 UTC 2010

Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.

Biochemical and biophysical research communications

Kawashima R,Ikematsu K,Abe Y,Sato M,Tsuruya S,Nakasono I,Fukushima H,Inoue K,Tsuboi T

Fri Sep 17 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Syntaxin-11

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Gene Aliases: 5830405C08Rik; FHL4; HLH4; HPLH4; STX11

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UniProt ID: (Human) O75558, (Mouse) Q9D3G5

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Entrez Gene ID: (Human) 8676, (Mouse) 74732, (Rat) 292483

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Function(s)

SNARE binding SNAP receptor activity protein binding

Process(es)

intracellular protein transport synaptic vesicle fusion to presynaptic active zone membrane vesicle docking membrane fusion T cell mediated cytotoxicity transport protein transport vesicle-mediated transport natural killer cell mediated cytotoxicity neutrophil degranulation cytotoxic T cell degranulation natural killer cell degranulation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Syntaxin 11 Polyclonal Antibody

Syntaxin 11 Antibody (13301-1-AP) in IHC (P)

Product Details

13301-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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