Proteintech

Syntaxin 17 Polyclonal Antibody

Syntaxin 17 Antibody in Immunocytochemistry (ICC/IF)

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Syntaxin 17 Antibody (17815-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 17815-1-AP (Syntaxin 17 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Syntaxin 17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Syntaxin 17 Antibody in Western Blot (WB)

Syntaxin 17 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17815-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 26 publications 26 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 9 publications 9 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Syntaxin 17 Fusion Protein Ag12134 (1-216 aa encoded by BC111009)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEDEEKVK LRRLEPAIQK FIKIVIPTDL ERLRKHQINI EKYQRCGIWD KLHEEHINAG RTVQQLRSNI REIEKLCLKV RKDDLVLLKR MIDPVKEEAS AATAEFLQLH LESVEELKKQ FNDEETLLQP PLTRSMTVGG AFHTTEAEAS SQSLTQIYAL PEIPQDQNAA ESWETLEADL IELSQLVTDF SLLVNSQQEK IDSIADHVNS AAVNVEE (1-216 aa encoded by BC111009)

Target Information

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. STX17 may also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. (Uniprot)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

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Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 UTC 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 UTC 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 UTC 2023

Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.

Hepatology (Baltimore, Md.)

Liu X,Tan S,Liu H,Jiang J,Wang X,Li L,Wu B

Sat Apr 01 00:00:00 UTC 2023

Porcine Reproductive and Respiratory Syndrome Virus nsp5 Induces Incomplete Autophagy by Impairing the Interaction of STX17 and SNAP29.

Microbiology spectrum

Zhou Y,Li Y,Tao R,Li J,Fang L,Xiao S

Thu Feb 23 00:00:00 UTC 2023

Porcine Reproductive and Respiratory Syndrome Virus nsp5 Induces Incomplete Autophagy by Impairing the Interaction of STX17 and SNAP29.

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Zhou Y,Li Y,Tao R,Li J,Fang L,Xiao S

Thu Feb 23 00:00:00 UTC 2023

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Toda N,Sato T,Muraoka M,Lin D,Saito M,Li G,Song QC,Yanagisawa T,Yamauchi M

Wed Feb 01 00:00:00 UTC 2023

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Free radical biology & medicine

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Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.

Free radical biology & medicine

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Wed Feb 01 00:00:00 UTC 2023

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins.

Journal of cell science

Fote GM,Geller NR,Efstathiou NE,Hendricks N,Vavvas DG,Reidling JC,Thompson LM,Steffan JS

Sat Jan 15 00:00:00 UTC 2022

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Autophagy

Yan JM,Zhang WK,Yan LN,Jiao YJ,Zhou CM,Yu XJ

Fri Jul 01 00:00:00 UTC 2022

Low syntaxin 17 expression in donor liver is associated with poor graft prognosis in recipients of living donor liver transplantation.

Hepatology research : the official journal of the Japan Society of Hepatology

Tomiyama T,Shimokawa M,Harada N,Toshida K,Morinaga A,Kosai-Fujimoto Y,Tomino T,Kurihara T,Nagao Y,Toshima T,Morita K,Itoh S,Yoshizumi T

Sat Oct 01 00:00:00 UTC 2022

TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.

Journal of hazardous materials

Tang H,Huang H,Wang D,Li P,Tian Z,Li D,Wang S,Ma R,Xia T,Wang A

Sun May 15 00:00:00 UTC 2022

TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.

Journal of hazardous materials

Tang H,Huang H,Wang D,Li P,Tian Z,Li D,Wang S,Ma R,Xia T,Wang A

Sun May 15 00:00:00 UTC 2022

Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.

Ecotoxicology and environmental safety

Zhang Y,Han X,Tang Y,Zhang J,Hu Z,Xu W,Yao P,Niu Q

Sat Jan 15 00:00:00 UTC 2022

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization.

Journal of experimental & clinical cancer research : CR

Li Z,Fu WJ,Chen XQ,Wang S,Deng RS,Tang XP,Yang KD,Niu Q,Zhou H,Li QR,Lin Y,Liang M,Li SS,Ping YF,Liu XD,Bian XW,Yao XH

Tue Feb 22 00:00:00 UTC 2022

Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells.

Toxicology and applied pharmacology

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Fri Jul 15 00:00:00 UTC 2022

Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells.

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Fri Jul 15 00:00:00 UTC 2022

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Tue Apr 20 00:00:00 UTC 2021

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Fri Jul 03 00:00:00 UTC 2020

Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.

Experimental neurology

Zheng Z,Zhou Y,Ye L,Lu Q,Zhang K,Zhang J,Xie L,Wu Y,Xu K,Zhang H,Xiao J

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Molecular and cellular endocrinology

Wang Y,Ji L,Peng Z,Lai R,Zhang X,Xu Y,Chen Z,Liu R,Zhong Y,Hu H,Wang L

Sat Feb 15 00:00:00 UTC 2020

Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.

Molecular and cellular endocrinology

Wang Y,Ji L,Peng Z,Lai R,Zhang X,Xu Y,Chen Z,Liu R,Zhong Y,Hu H,Wang L

Sat Feb 15 00:00:00 UTC 2020

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Tian X,Zheng P,Zhou C,Wang X,Ma H,Ma W,Zhou X,Teng J,Chen J

Fri May 01 00:00:00 UTC 2020

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Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.

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Jian F,Chen D,Chen L,Yan C,Lu B,Zhu Y,Chen S,Shi A,Chan DC,Song Z

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Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.

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McLelland GL,Goiran T,Yi W,Dorval G,Chen CX,Lauinger ND,Krahn AI,Valimehr S,Rakovic A,Rouiller I,Durcan TM,Trempe JF,Fon EA

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Morales I,Sanchez A,Rodriguez-Sabate C,Rodriguez M

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Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.

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Morales I,Sanchez A,Rodriguez-Sabate C,Rodriguez M

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Li X,Zhu F,Jiang J,Sun C,Zhong Q,Shen M,Wang X,Tian R,Shi C,Xu M,Peng F,Guo X,Hu J,Ye D,Wang M,Qin R

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Li X,Zhu F,Jiang J,Sun C,Zhong Q,Shen M,Wang X,Tian R,Shi C,Xu M,Peng F,Guo X,Hu J,Ye D,Wang M,Qin R

Thu Sep 01 00:00:00 UTC 2016

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

The Journal of cell biology

McLelland GL,Lee SA,McBride HM,Fon EA

Mon Aug 01 00:00:00 UTC 2016

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

The Journal of cell biology

McLelland GL,Lee SA,McBride HM,Fon EA

Mon Aug 01 00:00:00 UTC 2016

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Yang H,Peng YF,Ni HM,Li Y,Shi YH,Ding WX,Fan J

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Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.

PloS one

Yang H,Peng YF,Ni HM,Li Y,Shi YH,Ding WX,Fan J

Wed Apr 06 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Syntaxin-17

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Gene Aliases: 4833418L03Rik; 6330411F21Rik; 9030425C21Rik; AW048351; STX17

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UniProt ID: (Human) P56962, (Rat) Q9Z158, (Mouse) Q9D0I4

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Entrez Gene ID: (Human) 55014, (Rat) 252853, (Mouse) 67727

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Function(s)

SNARE binding SNAP receptor activity protein binding protein kinase binding protein phosphatase binding

Process(es)

intracellular protein transport ER to Golgi vesicle-mediated transport vesicle fusion Golgi organization protein localization to pre-autophagosomal structure vesicle docking endoplasmic reticulum-Golgi intermediate compartment organization autophagosome maturation transport autophagy vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Syntaxin 17 Polyclonal Antibody

Syntaxin 17 Antibody (17815-1-AP) in ICC/IF

Product Details

17815-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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