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Syntaxin 1A / Syntaxin 1B Monoclonal Antibody (2D3B5)

Syntaxin 1A / Syntaxin 1B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Syntaxin 1A / Syntaxin 1B Antibody (66437-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Rat brain tissue slide using (Product # 66437-1-Ig) Syntaxin 1A/Syntaxin 1B antibody at dilution of 1:4,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Syntaxin 1A / Syntaxin 1B Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Syntaxin 1A / Syntaxin 1B Antibody in Western Blot (WB)

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Product Details

66437-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:4,000

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D3B5

Immunogen

Syntaxin 1A / Syntaxin 1B Fusion Protein Ag10257 (1-263 aa encoded by BC062298)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKDRTQELR SAKDSDDEEE VVHVDRDHFM DEFFEQVEEI RGCIEKLSED VEQVKKQHSA ILAAPNPDEK TKQELEDLTA DIKKTANKVR SKLKAIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MTEYNATQSK YRDRCKDRIQ RQLEITGRTT TNEELEDMLE SGKLAIFTDD IKMDSQMTKQ ALNEIETRHN EIIKLETSIR ELHDMFVDMA MLVESQGEMI DRIEYNVEHS VDYVERAVSD TKKAVKYQSK ARRK (1-263 aa encoded by BC062298)

Target Information

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Heterozygous disruption of beclin 1 alleviates neurotoxicity induced by sub-chronic exposure of arsenite in mice.

Neurotoxicology

Li D,Qin Q,Xia Y,Cheng S,Zhang J,Duan X,Qin X,Tian X,Mao L,Qiu J,Jiang X,Zou Z,Chen C

Sun Jan 01 00:00:00 UTC 2023

Confinement induces oxidative damage and synaptic dysfunction in mice.

Frontiers in physiology

Li N,Wang H,Xin S,Min R,Zhang Y,Deng Y

Thu Dec 22 00:00:00 UTC 2022

Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor.

Journal of neuroinflammation

Chen B,Qin G,Xiao J,Deng X,Lin A,Liu H

Wed Jul 13 00:00:00 UTC 2022

Fast resupply of synaptic vesicles requires synaptotagmin-3.

Nature

Weingarten DJ,Shrestha A,Juda-Nelson K,Kissiwaa SA,Spruston E,Jackman SL

Tue Nov 01 00:00:00 UTC 2022

Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits.

Brain communications

Williams JB,Cao Q,Yan Z

Mon May 06 00:00:00 UTC 2024

Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits.

Brain communications

Williams JB,Cao Q,Yan Z

Mon May 06 00:00:00 UTC 2024

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells.

Clinical science (London, England : 1979)

Chen J,Wang F,Zhou Y,Jiang J,Ksimu S,Zhang X,Li JZ,Niu J,Wang Q

Fri Mar 13 00:00:00 UTC 2020

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Nature communications

Wang S,Li Y,Gong J,Ye S,Yang X,Zhang R,Ma C

Tue Jan 08 00:00:00 UTC 2019

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Nature communications

Wang S,Li Y,Gong J,Ye S,Yang X,Zhang R,Ma C

Tue Jan 08 00:00:00 UTC 2019

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: adipocyte; adiponectin; FP17469; HGNC:11433; Neuron-specific antigen HPC-1; P35A; P35B; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; syntaxin 1B1; syntaxin 1B2; Syntaxin 2; syntaxin a/b; Syntaxin-1A; Syntaxin-1B; Syntaxin-1B1; Syntaxin-1B2

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Gene Aliases: GEFSP9; HPC-1; P35-1; Sap; STX1; STX1A; STX1B; STX1B1; STX1B2; Stx1bl; Stx2; SYN1A; Syn1b

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UniProt ID: (Human) Q16623, (Human) P61266, (Mouse) O35526, (Rat) P32851, (Mouse) P61264, (Rat) P61265

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Entrez Gene ID: (Human) 6804, (Human) 112755, (Mouse) 20907, (Rat) 116470, (Mouse) 56216, (Rat) 24923

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Function(s)

SNARE binding glycoprotein binding SNAP receptor activity protein binding myosin binding calcium channel inhibitor activity chloride channel inhibitor activity kinase binding protein domain specific binding protein binding, bridging myosin head/neck binding ATP-dependent protein binding ion channel binding protein heterodimerization activity protein N-terminus binding calcium-dependent protein binding protein kinase binding

Process(es)

positive regulation of neurotransmitter secretion transport neurotransmitter transport intracellular protein transport exocytosis regulation of gene expression regulation of synaptic vesicle priming protein transport synaptic vesicle docking vesicle-mediated transport regulation of exocytosis synaptic vesicle fusion to presynaptic active zone membrane spontaneous neurotransmitter secretion positive regulation of excitatory postsynaptic potential response to gravity positive regulation of norepinephrine secretion calcium ion regulated exocytosis secretion by cell positive regulation of catecholamine secretion positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis vesicle docking neurotransmitter secretion glutamate secretion regulation of insulin secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Syntaxin 1A / Syntaxin 1B Monoclonal Antibody (2D3B5)

Syntaxin 1A / Syntaxin 1B Antibody (66437-1-IG) in IHC (P)

Product Details

66437-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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