Proteintech

Syntaxin 6 Polyclonal Antibody

Syntaxin 6 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 13

Syntaxin 6 Antibody (10841-1-AP) in ICC/IF

IF result of anti-STX6 (10841-1-AP) in Murine Spleen-DC by Dr. LOREDANA SAVEANU.

Syntaxin 6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Syntaxin 6 Antibody in Western Blot (WB)

Syntaxin 6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10841-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 11 publications 11 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Syntaxin 6 Fusion Protein Ag1284 (1-255 aa encoded by BC009944)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSMEDPFFV VKGEVQKAVN TAQGLFQRWT ELLQDPSTAT REEIDWTTNE LRNNLRSIEW DLEDLDETIS IVEANPRKFN LDATELSIRK AFITSTRQVV RDMKDQMSTS SVQALAERKN RQALLGDSGS QNWSTGTTDK YGRLDRELQR ANSHFIEEQQ AQQQLIVEQQ DEQLELVSGS IGVLKNMSQR IGGELEEQAV MLEDFSHELE STQSRLDNVM KKLAKVSHMT SDRRQWCAIA ILFAVLLVVL ILFLVL (1-255 aa encoded by B C009944)

Target Information

Syntaxin 6 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi.

The Journal of allergy and clinical immunology

Weimershaus M,Carvalho C,Rignault R,Waeckel-Enee E,Dussiot M,van Endert P,Maciel TT,Hermine O

Thu Jun 01 00:00:00 UTC 2023

Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zheng S,Lin J,Pang Z,Zhang H,Wang Y,Ma L,Zhang H,Zhang X,Chen M,Zhang X,Zhao C,Qi J,Cao L,Wang M,He X,Sheng R

Sat Oct 01 00:00:00 UTC 2022

Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.

Cell reports. Medicine

Hamel Y,Mauvais FX,Madrange M,Renard P,Lebreton C,Nemazanyy I,Pellé O,Goudin N,Tang X,Rodero MP,Tuchmann-Durand C,Nusbaum P,Brindley DN,van Endert P,de Lonlay P

Tue Aug 17 00:00:00 UTC 2021

Thioxothiazolidin derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase-containing vesicles to lysosome.

Journal of cellular biochemistry

Isogawa K,Asano M,Hayazaki M,Koga K,Watanabe M,Suzuki K,Kobayashi T,Kawaguchi K,Ishizuka A,Kato S,Ito H,Hamamoto A,Koyama H,Furuta K,Takemori H

Tue Jun 01 00:00:00 UTC 2021

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells.

Frontiers in cell and developmental biology

Weimershaus M,Mauvais FX,Evnouchidou I,Lawand M,Saveanu L,van Endert P

Tue Jan 12 00:00:00 UTC 2021

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

Nature communications

Evnouchidou I,Chappert P,Benadda S,Zucchetti A,Weimershaus M,Bens M,Caillens V,Koumantou D,Lotersztajn S,van Endert P,Davoust J,Guermonprez P,Hivroz C,Gross DA,Saveanu L

Tue Jun 02 00:00:00 UTC 2020

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

Nature communications

Evnouchidou I,Chappert P,Benadda S,Zucchetti A,Weimershaus M,Bens M,Caillens V,Koumantou D,Lotersztajn S,van Endert P,Davoust J,Guermonprez P,Hivroz C,Gross DA,Saveanu L

Tue Jun 02 00:00:00 UTC 2020

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.

The Biochemical journal

Malik N,Nirujogi RS,Peltier J,Macartney T,Wightman M,Prescott AR,Gourlay R,Trost M,Alessi DR,Karapetsas A

Wed Oct 30 00:00:00 UTC 2019

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.

Cell reports

Weimershaus M,Mauvais FX,Saveanu L,Adiko C,Babdor J,Abramova A,Montealegre S,Lawand M,Evnouchidou I,Huber KJ,Chadt A,Zwick M,Vargas P,Dussiot M,Lennon-Dumenil AM,Brocker T,Al-Hasani H,van Endert P

Tue Sep 25 00:00:00 UTC 2018

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.

Cell reports

Weimershaus M,Mauvais FX,Saveanu L,Adiko C,Babdor J,Abramova A,Montealegre S,Lawand M,Evnouchidou I,Huber KJ,Chadt A,Zwick M,Vargas P,Dussiot M,Lennon-Dumenil AM,Brocker T,Al-Hasani H,van Endert P

Tue Sep 25 00:00:00 UTC 2018

Proteomic analysis of insulin secretory granules in INS-1 cells by protein correlation profiling.

Biophysics reports

Li M,Du W,Zhou M,Zheng L,Song E,Hou J

Wed Mar 30 00:00:00 UTC 2022

IRAP⁺ endosomes restrict TLR9 activation and signaling.

Nature immunology

Babdor J,Descamps D,Adiko AC,Tohmé M,Maschalidi S,Evnouchidou I,Vasconcellos LR,De Luca M,Mauvais FX,Garfa-Traore M,Brinkmann MM,Chignard M,Manoury B,Saveanu L

Mon May 01 00:00:00 UTC 2017

IRAP⁺ endosomes restrict TLR9 activation and signaling.

Nature immunology

Babdor J,Descamps D,Adiko AC,Tohmé M,Maschalidi S,Evnouchidou I,Vasconcellos LR,De Luca M,Mauvais FX,Garfa-Traore M,Brinkmann MM,Chignard M,Manoury B,Saveanu L

Mon May 01 00:00:00 UTC 2017

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

Immunology and cell biology

De Angelis Rigotti F,De Gassart A,Pforr C,Cano F,N'Guessan P,Combes A,Camossetto V,Lehner PJ,Pierre P,Gatti E

Sun Oct 01 00:00:00 UTC 2017

Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system.

Scientific reports

Su X,Liang H,Wang H,Chen G,Jiang H,Wu Q,Liu T,Liu Q,Yu T,Gu Y,Yang B,Shan H

Tue Apr 11 00:00:00 UTC 2017

Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system.

Scientific reports

Su X,Liang H,Wang H,Chen G,Jiang H,Wu Q,Liu T,Liu Q,Yu T,Gu Y,Yang B,Shan H

Tue Apr 11 00:00:00 UTC 2017

Poster Session Abstracts.

Pediatric pulmonology

No authors listed

Thu Oct 01 00:00:00 UTC 2015

Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation.

Journal of immunology (Baltimore, Md. : 1950)

Weimershaus M,Maschalidi S,Sepulveda F,Manoury B,van Endert P,Saveanu L

Wed Feb 15 00:00:00 UTC 2012

Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation.

Journal of immunology (Baltimore, Md. : 1950)

Weimershaus M,Maschalidi S,Sepulveda F,Manoury B,van Endert P,Saveanu L

Wed Feb 15 00:00:00 UTC 2012

HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus.

Protein & cell

Wang L,Zhan Y,Song E,Yu Y,Jiu Y,Du W,Lu J,Liu P,Xu P,Xu T

Sat Jan 01 00:00:00 UTC 2011

HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus.

Protein & cell

Wang L,Zhan Y,Song E,Yu Y,Jiu Y,Du W,Lu J,Liu P,Xu P,Xu T

Sat Jan 01 00:00:00 UTC 2011

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

Science (New York, N.Y.)

Saveanu L,Carroll O,Weimershaus M,Guermonprez P,Firat E,Lindo V,Greer F,Davoust J,Kratzer R,Keller SR,Niedermann G,van Endert P

Fri Jul 10 00:00:00 UTC 2009

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

Science (New York, N.Y.)

Saveanu L,Carroll O,Weimershaus M,Guermonprez P,Firat E,Lindo V,Greer F,Davoust J,Kratzer R,Keller SR,Niedermann G,van Endert P

Fri Jul 10 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: HGNC:11441; Syn6; Syntaxin-6

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Gene Aliases: 2310039E05Rik; 2410005I16Rik; AA437559; AI415714; AI845861; STX6

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UniProt ID: (Human) O43752, (Mouse) Q9JKK1, (Rat) Q63635

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Entrez Gene ID: (Human) 10228, (Mouse) 58244, (Rat) 60562

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Function(s)

SNAP receptor activity protein binding syntaxin binding

Process(es)

intracellular protein transport vesicle fusion endosome organization endocytic recycling regulation of protein localization retrograde transport, endosome to Golgi Golgi vesicle transport vesicle docking Golgi ribbon formation regulation of cellular protein localization transport protein transport vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Syntaxin 6 Polyclonal Antibody

Syntaxin 6 Antibody (10841-1-AP) in ICC/IF

Product Details

10841-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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