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Invitrogen
Syntenin 1 Polyclonal Antibody
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FIGURE: 1 / 6
Syntenin 1 Antibody (PA5-28813) in ICC/IF
Immunocytochemistry (Confocal immunofluorescence) of Syntenin 1 in paraformaldehyde-fixed HeLa. Samples were incubated with Syntenin 1 polyclonal antibody (Product # PA5-28813) using a dilution of 1:500 (green). Alpha-tubulin filaments were labeled with alpha Tubulin monoclonal antibody (Product # MA1-25054) (Red) at 1:2,000.
Product Details
PA5-28813
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Syntenin 1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2546289
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; sdcbp; syndecan binding protein (syntenin); syndecan interacting protein; Syndecan-binding protein 1; syntenin; Syntenin-1; syntenin-b; TACIP18
Gene Aliases: MDA-9; MDA9; sb:eu862; SDCBP; si:dkey-235k4.1; ST1; SYCL; syntenin-1; TACIP18
UniProt ID: (Human) O00560, (Mouse) O08992
Entrez Gene ID: (Human) 6386, (Mouse) 53378, (Zebrafish) 407719
glycoprotein binding
frizzled binding
interleukin-5 receptor binding
protein binding
protein C-terminus binding
cytoskeletal adaptor activity
growth factor binding
neurexin family protein binding
identical protein binding
protein homodimerization activity
syndecan binding
ephrin receptor binding
protein heterodimerization activity
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
cell adhesion molecule binding
negative regulation of receptor internalization
protein targeting to membrane
substrate-dependent cell migration, cell extension
Ras protein signal transduction
chemical synaptic transmission
regulation of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
actin cytoskeleton organization
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of JNK cascade
ephrin receptor signaling pathway
cell-cell adhesion
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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