Product References
Excessive apoptosis of Rip1-deficient T cells leads to premature aging.
EMBO reports
Wang L,Zhang X,Zhang H,Lu K,Li M,Li X,Ou Y,Zhao X,Wu X,Wu X,Liu J,Xing M,Liu H,Zhang Y,Tan Y,Li F,Deng X,Deng J,Zhang X,Li J,Zhao Y,Ding Q,Wang H,Wang X,Luo Y,Zhou B,Zhang H
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Wed Dec 06 00:00:00 UTC 2023
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Thu Oct 12 00:00:00 UTC 2023
The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations.
International journal of molecular sciences
Chan L,Mehrani Y,Minott JA,Bridle BW,Karimi K
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Thu Jan 26 00:00:00 UTC 2023
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Cell reports
Viladomiu M,Khounlotham M,Dogan B,Lima SF,Elsaadi A,Cardakli E,Castellanos JG,Ng C,Herzog J,Schoenborn AA,Ellermann M,Liu B,Zhang S,Gulati AS,Sartor RB,Simpson KW,Lipkin SM,Longman RS
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Nov 15 00:00:00 UTC 2022
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner.
Journal of cell science
Korniotis S,Saichi M,Trichot C,Hoffmann C,Amblard E,Viguier A,Grondin S,Noel F,Mattoo H,Soumelis V
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Nov 01 00:00:00 UTC 2022
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Cellular & molecular immunology
Liu Y,Bockermann R,Hadi M,Safari I,Carrion B,Kveiborg M,Issazadeh-Navikas S
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Sun Aug 01 00:00:00 UTC 2021
Splicing factor SRSF1 limits IFN-γ production via RhoH and ameliorates experimental nephritis.
Rheumatology (Oxford, England)
Katsuyama T,Li H,Krishfield SM,Kyttaris VC,Moulton VR
14-5825-82 was used in Flow Cytometry to uncover a previously unrecognized role of SRSF1 in restraining IFN-γ production and Th1 differentiation through the control of RhoH.
Tue Jan 05 00:00:00 UTC 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Thu Apr 01 00:00:00 UTC 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Jan 11 00:00:00 UTC 2022
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.
Nature communications
Zhao Z,Wang H,Shi M,Zhu T,Pediongco T,Lim XY,Meehan BS,Nelson AG,Fairlie DP,Mak JYW,Eckle SBG,de Lima Moreira M,Tumpach C,Bramhall M,Williams CG,Lee HJ,Haque A,Evrard M,Rossjohn J,McCluskey J,Corbett AJ,Chen Z
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Fri Jul 16 00:00:00 UTC 2021
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Cell reports. Medicine
Bonilla WV,Kirchhammer N,Marx AF,Kallert SM,Krzyzaniak MA,Lu M,Darbre S,Schmidt S,Raguz J,Berka U,Vincenti I,Pauzuolis M,Kerber R,Hoepner S,Günther S,Magnus C,Merkler D,Orlinger KK,Zippelius A,Pinschewer DD
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Mar 16 00:00:00 UTC 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells.
STAR protocols
Sia WR,Hey YY,Foo R,Wang LF,Leeansyah E
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Fri Jun 18 00:00:00 UTC 2021
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells.
Cell reports
McLane LM,Ngiow SF,Chen Z,Attanasio J,Manne S,Ruthel G,Wu JE,Staupe RP,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Freedman BD,Betts MR,Wherry EJ
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Immunocytochemistry
Tue May 11 00:00:00 UTC 2021
C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
Shen ZY,Zheng Y,Pecsok MK,Wang K,Li W,Gong MJ,Wu F,Zhang L
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Western Blot
Thu Jul 01 00:00:00 UTC 2021
Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection.
Cell reports. Medicine
Rouers A,Chng MHY,Lee B,Rajapakse MP,Kaur K,Toh YX,Sathiakumar D,Loy T,Thein TL,Lim VWX,Singhal A,Yeo TW,Leo YS,Vora KA,Casimiro D,Lim B,Tucker-Kellogg L,Rivino L,Newell EW,Fink K
14-5825-82 was used in Flow Cytometry to reveal associations between cellular profiles and disease severity, opening opportunities to study immunopathology in dengue disease and the potential predictive value of these parameters.
Tue May 18 00:00:00 UTC 2021
Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning.
Laboratory investigation; a journal of technical methods and pathology
Hermsen M,Volk V,Bräsen JH,Geijs DJ,Gwinner W,Kers J,Linmans J,Schaadt NS,Schmitz J,Steenbergen EJ,Swiderska-Chadaj Z,Smeets B,Hilbrands LB,Feuerhake F,van der Laak JAWM
14-5825-82 was used in Immunohistochemistry to demonstrate that CNNs can be used to leverage reliable, quantitative results from mTSA-stained, multi spectrally imaged slides of kidney transplant biopsies.
Sun Aug 01 00:00:00 UTC 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-5825-82 was used in Flow Cytometry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 UTC 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-5825-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 UTC 2020
Mir-124 Attenuates STAT3-Mediated TH17 Differentiation in Colitis-Driven Colon Cancer.
Frontiers in oncology
Lin S,Liu Q,Wen J,Bai K,Guo Y,Wang J
14-5825-82 was used in Western blot to investigate if miR-124 acts as a safeguard to inhibit the pro-inflammatory production and reparative regeneration.
Fri Nov 01 00:00:00 UTC 2024
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Sep 22 00:00:00 UTC 2020
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Mon May 31 00:00:00 UTC 2021
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Cancers
Tao L,Farooq MA,Gao Y,Zhang L,Niu C,Ajmal I,Zhou Y,He C,Zhao G,Yao J,Liu M,Jiang W
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Sun Sep 13 00:00:00 UTC 2020
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
14-5825 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.
Science advances
Si Y,Tian Q,Zhao F,Kelly SH,Shores LS,Camacho DF,Sperling AI,Andrade MS,Collier JH,Chong AS
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Sat Aug 01 00:00:00 UTC 2020
Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level.
Gastroenterology
Karimzadeh H,Kiraithe MM,Oberhardt V,Salimi Alizei E,Bockmann J,Schulze Zur Wiesch J,Budeus B,Hoffmann D,Wedemeyer H,Cornberg M,Krawczyk A,Rashidi-Alavijeh J,Rodríguez-Frías F,Casillas R,Buti M,Smedile A,Alavian SM,Heinold A,Emmerich F,Panning M,Gostick E,Price DA,Timm J,Hofmann M,Raziorrouh B,Thimme R,Protzer U,Roggendorf M,Neumann-Haefelin C
14-5825-82 was used in Flow cytometry/Cell sorting to study how hepatitis D virus escapes the CD8+ T-cell-mediated response and which hepatitis D virus epitopes are targeted by virus-specific CD8+ T cells.
Wed May 01 00:00:00 UTC 2019
Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology.
The Journal of allergy and clinical immunology
Tumes D,Hirahara K,Papadopoulos M,Shinoda K,Onodera A,Kumagai J,Yip KH,Pant H,Kokubo K,Kiuchi M,Aoki A,Obata-Ninomiya K,Tokoyoda K,Endo Y,Kimura MY,Nakayama T
14-5825-82 was used in Immunocytochemistry to determine whether the polycomb repressive complex 2 protein enhancer of zeste homolog 2 (Ezh2) restrains pathogenicity of NKT cells in the context of asthma-like lung disease.
Thu Aug 01 00:00:00 UTC 2019
CD24+ Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition.
Immune network
Park JY,Kwon J,Kim EY,Fink J,Kim HK,Park JH
14-5825 was used in Flow cytometry/Cell sorting to test magnetic-activated depletion of CD24+ immature thymocytes as an alternative method to enrich iNKT cells.
Mon Apr 01 00:00:00 UTC 2019
FCRL5+ Memory B Cells Exhibit Robust Recall Responses.
Cell reports
Kim CC,Baccarella AM,Bayat A,Pepper M,Fontana MF
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Apr 30 00:00:00 UTC 2019
The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype.
Frontiers in immunology
Cuff AO,Sillito F,Dertschnig S,Hall A,Luong TV,Chakraverty R,Male V
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Wed Oct 21 00:00:00 UTC 2020
Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells.
Cell reports
Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Dec 03 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Mon Jul 22 00:00:00 UTC 2019
TIGIT signaling restores suppressor function of Th1 Tregs.
JCI insight
Lucca LE,Axisa PP,Singer ER,Nolan NM,Dominguez-Villar M,Hafler DA
14-5825 was used in Flow cytometry/Cell sorting to demonstrate an important role for TIGIT in controlling the functional stability of Tregs through repression of Akt, suggesting that the TIGIT pathway could be targeted for immunomodulatory therapies in human autoimmune disorders.
Thu Feb 07 00:00:00 UTC 2019
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.
ImmunoHorizons
Poholek CH,Dulson SJ,Zajac AJ,Harrington LE
14-5825 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.
Tue Jun 04 00:00:00 UTC 2019
Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations.
Science immunology
Dutton EE,Gajdasik DW,Willis C,Fiancette R,Bishop EL,Camelo A,Sleeman MA,Coccia M,Didierlaurent AM,Tomura M,Pilataxi F,Morehouse CA,Carlesso G,Withers DR
14-5825-82 was used in Flow cytometry/Cell sorting to determine whether migratory innate lymphoid cells exist within peripheral lymph nodes (LNs).
Fri May 31 00:00:00 UTC 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
The Journal of clinical investigation
Mande P,Zirak B,Ko WC,Taravati K,Bride KL,Brodeur TY,Deng A,Dresser K,Jiang Z,Ettinger R,Fitzgerald KA,Rosenblum MD,Harris JE,Marshak-Rothstein A
14-5825 was used in Flow cytometry/Cell sorting to provide a relevant system for exploring the pathophysiology of cutaneous lupus erythematosus (CLE) as well as the negative regulatory role of TLR9.
Mon Jul 02 00:00:00 UTC 2018
TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Wed Sep 26 00:00:00 UTC 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Mon Feb 05 00:00:00 UTC 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-5825 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 UTC 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-5825-82 was used in Flow Cytometry to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 UTC 2018
Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection.
Clinical & translational immunology
Ng SS,Souza-Fonseca-Guimaraes F,Rivera FL,Amante FH,Kumar R,Gao Y,Sheel M,Beattie L,Montes de Oca M,Guillerey C,Edwards CL,Faleiro RJ,Frame T,Bunn PT,Vivier E,Godfrey DI,Pellicci DG,Lopez JA,Andrews KT,Huntington ND,Smyth MJ,McCarthy J,Engwerda CR
14-5825 was used in Flow cytometry/Cell sorting to characterise the role of group 1 ILCs during Plasmodium infection.
Wed Sep 30 00:00:00 UTC 2020
Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization.
Scientific reports
Gnipp S,Mergia E,Puschkarow M,Bufe A,Koesling D,Peters M
14-5825 was used in Flow cytometry/Cell sorting to show that activity of NO-GC1 in DCs is important for the magnitude and bias of the Th response in allergic airway disease most likely by counteracting intracellular cAMP.
Fri Jul 20 00:00:00 UTC 2018
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-5825-82 was used in Flow Cytometry to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 UTC 2017
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
The Journal of experimental medicine
Daley D,Mani VR,Mohan N,Akkad N,Pandian GSDB,Savadkar S,Lee KB,Torres-Hernandez A,Aykut B,Diskin B,Wang W,Farooq MS,Mahmud AI,Werba G,Morales EJ,Lall S,Wadowski BJ,Rubin AG,Berman ME,Narayanan R,Hundeyin M,Miller G
14-5825-82 was used in Flow Cytometry to suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.
Mon Jun 05 00:00:00 UTC 2017
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
The Journal of experimental medicine
Daley D,Mani VR,Mohan N,Akkad N,Pandian GSDB,Savadkar S,Lee KB,Torres-Hernandez A,Aykut B,Diskin B,Wang W,Farooq MS,Mahmud AI,Werba G,Morales EJ,Lall S,Wadowski BJ,Rubin AG,Berman ME,Narayanan R,Hundeyin M,Miller G
14-5825-82 was used in Flow Cytometry to suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.
Mon Jun 05 00:00:00 UTC 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-5825 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 UTC 2017
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells.
Journal of leukocyte biology
Rampoldi F,Brunk F,Bonrouhi M,Federico G,Krunic D,Porubsky S,Gröne HJ,Popovic ZV
14582582 was used in flow cytometry to evaluate the potential role of the attachment of myristic acid to the N-terminal glycine of proteins on the activation of gamma delta T cells
Sat Apr 01 00:00:00 UTC 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Sep 05 00:00:00 UTC 2017
Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Nature communications
Brownlie RJ,Garcia C,Ravasz M,Zehn D,Salmond RJ,Zamoyska R
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Nov 07 00:00:00 UTC 2017
Conventional NK cells and ILC1 are partially ablated in the livers of Ncr1 iCreTbx21 fl/fl mice.
Wellcome open research
Cuff AO,Male V
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Sat Jan 09 00:00:00 UTC 2021
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Thu Aug 25 00:00:00 UTC 2016
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Nature immunology
Hukelmann JL,Anderson KE,Sinclair LV,Grzes KM,Murillo AB,Hawkins PT,Stephens LR,Lamond AI,Cantrell DA
Fri Jan 01 00:00:00 UTC 2016
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Journal of internal medicine
Frodermann V,van Duijn J,van Puijvelde GH,van Santbrink PJ,Lagraauw HM,de Vries MR,Quax PH,Bot I,Foks AC,de Jager SC,Kuiper J
14582582 was used in flow cytometry to test whether heat-killed Staphyloccocus aureus inhibits the development of atherosclerosis
Wed Jun 01 00:00:00 UTC 2016
Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
PLoS pathogens
Roberts ER,Carnathan DG,Li H,Shaw GM,Silvestri G,Betts MR
14582582 was used in flow cytometry to examine the kinetics of SIV-specific CD8+ T cell cytolytic factor expression in peripheral blood, lymph node, spleen, and gut mucosa from early acute infection through chronic infection
Thu Dec 01 00:00:00 UTC 2016
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.
European journal of immunology
Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Younis RH,Han KL,Webb TJ
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
14582582 was used in flow cytometry to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways
Mon Apr 18 00:00:00 UTC 2016
Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.
Scientific reports
Martínez Gómez JM,Periasamy P,Dutertre CA,Irving AT,Ng JH,Crameri G,Baker ML,Ginhoux F,Wang LF,Alonso S
14582582 was used in flow cytometry to describe the phenotypic and functional characterization of T cell subsets, B and NK cells in the fruit-eating bat Pteropus alecto
Thu Nov 24 00:00:00 UTC 2016
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Clinical & translational immunology
Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S
14-5825 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.
Mon Aug 01 00:00:00 UTC 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
14582582 was used in flow cytometry to study the contribution of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer cell activation and tumor control
Wed Jun 01 00:00:00 UTC 2016
Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut.
Immunity
Kim MH,Taparowsky EJ,Kim CH
14582582 was used in flow cytometry to discuss tissue tropisms of innate lymphoid cells
Tue Jul 21 00:00:00 UTC 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-5825 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 UTC 2015
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Nature immunology
Lynch L,Michelet X,Zhang S,Brennan PJ,Moseman A,Lester C,Besra G,Vomhof-Dekrey EE,Tighe M,Koay HF,Godfrey DI,Leadbetter EA,Sant'Angelo DB,von Andrian U,Brenner MB
14-5825 was used in Flow cytometry/Cell sorting to report a unique transcriptional program of iNKT cells in adipose tissue, making them unique regulators of immunological homeostasis.
Thu Jan 01 00:00:00 UTC 2015
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
The Journal of clinical investigation
Pollizzi KN,Patel CH,Sun IH,Oh MH,Waickman AT,Wen J,Delgoffe GM,Powell JD
14-5825 was used in Flow cytometry/Cell sorting to define specific roles for mTORC1 and mTORC2 in the specification of immune cell subsets.
Fri May 01 00:00:00 UTC 2015
PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.
The Journal of experimental medicine
Yang M,Li D,Chang Z,Yang Z,Tian Z,Dong Z
14-5825 was used in Flow cytometry/Cell sorting to investigate the signals required to induce E4BP4 expression and its effects on NK cell development in mice.
Mon Feb 09 00:00:00 UTC 2015
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
The Journal of experimental medicine
Omilusik KD,Best JA,Yu B,Goossens S,Weidemann A,Nguyen JV,Seuntjens E,Stryjewska A,Zweier C,Roychoudhuri R,Gattinoni L,Bird LM,Higashi Y,Kondoh H,Huylebroeck D,Haigh J,Goldrath AW
14-5825 was used in Chromatin immunoprecipitation to study the upregulation of ZEB2 by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset.
Mon Nov 16 00:00:00 UTC 2015
Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.
The Journal of experimental medicine
Dobenecker MW,Kim JK,Marcello J,Fang TC,Prinjha R,Bosselut R,Tarakhovsky A
14-5825 was used in Flow cytometry/Cell sorting to enable precise coupling of TCR specificity to lineage commitment.
Mon Mar 09 00:00:00 UTC 2015
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.
Science advances
Hoffmann MM,Molina-Mendiola C,Nelson AD,Parks CA,Reyes EE,Hansen MJ,Rajagopalan G,Pease LR,Schrum AG,Gil D
14-5825 was used in Flow cytometry/Cell sorting to investigate co-potentiation, showing that weak T-cell responses can be boosted to provide immunotherapy in vivo.
Thu Oct 01 00:00:00 UTC 2015
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.
Frontiers in immunology
Shen W,Hixon JA,McLean MH,Li WQ,Durum SK
14-5825 was used in Flow cytometry/Cell sorting to identify and explore the function, plasticity, pathogenicity and location of IL-22-expressing lymphocytes in reporter mice.
Tue Feb 02 00:00:00 UTC 2016
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway.
Mucosal immunology
Park J,Kim M,Kang SG,Jannasch AH,Cooper B,Patterson J,Kim CH
14-5825 was used in Flow cytometry/Cell sorting to show that short-chain fatty acids promote T-cell differentiation to promote either immunity or immune tolerance.
Thu Jan 01 00:00:00 UTC 2015
The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.
European journal of immunology
Goyvaerts C,Broos K,Escors D,Heirman C,Raes G,De Baetselier P,Thielemans K,Breckpot K
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Dec 01 00:00:00 UTC 2015
T follicular helper, but not Th1, cell differentiation in the absence of conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Dahlgren MW,Gustafsson-Hedberg T,Livingston M,Cucak H,Alsén S,Yrlid U,Johansson-Lindbom B
14-5825 was used in Flow cytometry/Cell sorting to investigate the accessory role of conventional DCs during the concurrent development of Tfh and effector Th1 cells.
Mon Jun 01 00:00:00 UTC 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-5825 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 UTC 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-5825 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 UTC 2015
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.
Journal of immunology (Baltimore, Md. : 1950)
Metz PJ,Arsenio J,Kakaradov B,Kim SH,Remedios KA,Oakley K,Akimoto K,Ohno S,Yeo GW,Chang JT
14-5825 was used in Immunocytochemistry-immunoflourescence to show that PKCζ and PKCλ/i regulate asymmetric localization of effector fate-associated factors during the first CD8+ T cell division in vivo.
Sun Mar 01 00:00:00 UTC 2015
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Yamashita-Kanemaru Y,Takahashi Y,Wang Y,Tahara-Hanaoka S,Honda S,Bernhardt G,Shibuya A,Shibuya K
14-5825-82 was used in Flow Cytometry to identify CD155 as a costimulatory molecule on CD4(+) T cells.
Mon Jun 15 00:00:00 UTC 2015
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA
14-5825 was used in Chromatin immunoprecipitation to demonstrate that patients have chronic lymphocytic leukemia (CLL)-specific Th cells that support CLL proliferation.
Thu Jan 15 00:00:00 UTC 2015
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA
14-5825 was used in Chromatin immunoprecipitation to demonstrate that patients have chronic lymphocytic leukemia (CLL)-specific Th cells that support CLL proliferation.
Thu Jan 15 00:00:00 UTC 2015
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA
14-5825 was used in Chromatin immunoprecipitation to demonstrate that patients have chronic lymphocytic leukemia (CLL)-specific Th cells that support CLL proliferation.
Thu Jan 15 00:00:00 UTC 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-5825 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 UTC 2015
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.
PloS one
Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue May 31 00:00:00 UTC 2016
NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine.
PloS one
Luci C,Bekri S,Bihl F,Pini J,Bourdely P,Nouhen K,Malgogne A,Walzer T,Braud VM,Anjuère F
14-5825 was used in Flow cytometry/Cell sorting to show that vaginal NKp46+ Innate lymphoid cells dampen vaccine-induced CD8 T cell responses generated after local immunization with a Cholera Toxin-Based Vaccine.
Thu Jun 23 00:00:00 UTC 2016
Trained immunity in newborn infants of HBV-infected mothers.
Nature communications
Hong M,Sandalova E,Low D,Gehring AJ,Fieni S,Amadei B,Urbani S,Chong YS,Guccione E,Bertoletti A
14-5825 was used in Immunohistochemistry to demonstrate that HBV exposure in utero enhances the ability of cord blood immune cells to respond to bacterial infection in vitro.
Wed Mar 25 00:00:00 UTC 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-5825 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 UTC 2015
Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice.
PloS one
Kornete M,Mason ES,Girouard J,Lafferty EI,Qureshi S,Piccirillo CA
14-5825 was used in Flow cytometry/Cell sorting to reveal that CXCR3-mediated trafficking of Tregs could represent a mechanism of homeostatic immunoregulation during diabetogenesis.
Mon Apr 25 00:00:00 UTC 2016
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
14-5825 was used in Flow cytometry/Cell sorting to investigate a T-cell-intrinsic function of the transcriptional regulator Bcl-3 in autoimmunity.
Thu Oct 16 00:00:00 UTC 2014
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Nature immunology
Heikamp EB,Patel CH,Collins S,Waickman A,Oh MH,Sun IH,Illei P,Sharma A,Naray-Fejes-Toth A,Fejes-Toth G,Misra-Sen J,Horton MR,Powell JD
14-5825 was used in Western Blotting to characterise the range of phenotypes generated for mice with selective deletion of SGK1 in T cells.
Thu May 01 00:00:00 UTC 2014
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Nature immunology
Heikamp EB,Patel CH,Collins S,Waickman A,Oh MH,Sun IH,Illei P,Sharma A,Naray-Fejes-Toth A,Fejes-Toth G,Misra-Sen J,Horton MR,Powell JD
14-5825 was used in Western Blotting to characterise the range of phenotypes generated for mice with selective deletion of SGK1 in T cells.
Thu May 01 00:00:00 UTC 2014
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
The Journal of clinical investigation
Araya N,Sato T,Ando H,Tomaru U,Yoshida M,Coler-Reilly A,Yagishita N,Yamauchi J,Hasegawa A,Kannagi M,Hasegawa Y,Takahashi K,Kunitomo Y,Tanaka Y,Nakajima T,Nishioka K,Utsunomiya A,Jacobson S,Yamano Y
14-5825 was used in Flow cytometry/Cell sorting to study the cellular changes leading to the development of an inflammatory response to Human T-lymphotropic virus type 1 infection.
Fri Aug 01 00:00:00 UTC 2014
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
PLoS biology
Sarrabayrouse G,Bossard C,Chauvin JM,Jarry A,Meurette G,Quévrain E,Bridonneau C,Preisser L,Asehnoune K,Labarrière N,Altare F,Sokol H,Jotereau F
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue Apr 01 00:00:00 UTC 2014
Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis.
Journal of immunology (Baltimore, Md. : 1950)
Drummond RA,Wallace C,Reid DM,Way SS,Kaplan DH,Brown GD
14-5825 was used in Flow cytometry/Cell sorting to explain the redundancy of CD4(+) T cells for defense against systemic infection with Candida albicans by characterising C. albicans-specific T cells.
Mon Dec 01 00:00:00 UTC 2014
Islet antigen-specific Th17 cells can induce TNF-α-dependent autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Li CR,Mueller EE,Bradley LM
14-5825 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism by which Th17 cells can contribute to T1D.
Sat Feb 15 00:00:00 UTC 2014
Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays.
PloS one
Jung HR,Song KH,Chang JT,Doh J
14-5825 was used in Immunofluorescence to investigate key factors that influence whether T cells will undergo symmetric or asymmetric divisions.
Tue Nov 18 00:00:00 UTC 2014
Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.
PloS one
Samuelson EM,Laird RM,Papillion AM,Tatum AH,Princiotta MF,Hayes SM
14-5825 was used in Flow cytometry/Cell sorting to demonstrate how BLK risk alleles confer susceptibility to systemic lupus erythematosus.
Tue Nov 11 00:00:00 UTC 2014
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-5825 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 UTC 2014
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Nature
Kleinewietfeld M,Manzel A,Titze J,Kvakan H,Yosef N,Linker RA,Muller DN,Hafler DA
14-5825 was used in Flow cytometry/Cell sorting to investigate the environmental factors that influence TH17 cells, showing that sodium chloride induces TH17 cells and drives autoimmune disease.
Thu Apr 25 00:00:00 UTC 2013
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.
Immunity
Bailis W,Yashiro-Ohtani Y,Fang TC,Hatton RD,Weaver CT,Artis D,Pear WS
14-5825 was used in Flow cytometry/Cell sorting to investigate the role of Notch in orchestrating Th cell differentiation.
Thu Jul 25 00:00:00 UTC 2013
Peptide vaccination in Montanide adjuvant induces and GM-CSF increases CXCR3 and cutaneous lymphocyte antigen expression by tumor antigen-specific CD8 T cells.
Cancer immunology research
Clancy-Thompson E,King LK,Nunnley LD,Mullins IM,Slingluff CL,Mullins DW
14-5825 was used in Flow cytometry/Cell sorting to assess the melanoma-infiltrating capability of CD8 T cells in the context of a clinical trial of a melanoma-specific peptide vaccine.
Fri Nov 01 00:00:00 UTC 2013
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.
Journal of immunology (Baltimore, Md. : 1950)
Himmel ME,MacDonald KG,Garcia RV,Steiner TS,Levings MK
14-5825 was used in Flow cytometry/Cell sorting to investigate the link between Helios expression and natural regulatory FOXP3+ T cell subsets from different origins in humans.
Fri Mar 01 00:00:00 UTC 2013
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses.
World journal of gastroenterology
Chen QQ,Yan L,Wang CZ,Wang WH,Shi H,Su BB,Zeng QH,Du HT,Wan J
Wed Aug 07 00:00:00 UTC 2013
Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.
PloS one
Yang MJ,Sim S,Jeon JH,Jeong E,Kim HC,Park YJ,Kim IB
14-5825 was used in Western Blotting to assess the role of nitration in the decline in olfactory sensory function observed in ageing mice.
Tue Sep 17 00:00:00 UTC 2013
Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.
PloS one
Yang MJ,Sim S,Jeon JH,Jeong E,Kim HC,Park YJ,Kim IB
14-5825 was used in Western Blotting to assess the role of nitration in the decline in olfactory sensory function observed in ageing mice.
Tue Sep 17 00:00:00 UTC 2013
Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.
PloS one
Schijf MA,Kerperien J,Bastiaans J,Szklany K,Meerding J,Hofman G,Boon L,van Wijk F,Garssen J,Van't Land B
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Tue May 27 00:00:00 UTC 2014
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-5825 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 UTC 2012
Transcutaneous vaccination via laser microporation.
Journal of controlled release : official journal of the Controlled Release Society
Weiss R,Hessenberger M,Kitzmüller S,Bach D,Weinberger EE,Krautgartner WD,Hauser-Kronberger C,Malissen B,Boehler C,Kalia YN,Thalhamer J,Scheiblhofer S
14-5825 was used in Flow cytometry/Cell sorting to investigate the potential of transcutaneous immunisation via laser-generated micropores for induction of specific immune responses.
Mon Sep 10 00:00:00 UTC 2012
Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Rao R,Vazzana J,Goedegebuure P,Odunsi K,Gillanders W,Shrikant PA
14-5825 was used in Flow cytometry/Cell sorting to indicate that judicious application of rapamycin can augment vaccine efficacy for chronic challenges.
Sun Apr 01 00:00:00 UTC 2012
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Nature immunology
El-Behi M,Ciric B,Dai H,Yan Y,Cullimore M,Safavi F,Zhang GX,Dittel BN,Rostami A
14-5825 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which IL-23 promotes pathogenicity of Th17 cells.
Wed Jun 01 00:00:00 UTC 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-5825 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 UTC 2011
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Qui HZ,Hagymasi AT,Bandyopadhyay S,St Rose MC,Ramanarasimhaiah R,Ménoret A,Mittler RS,Gordon SM,Reiner SL,Vella AT,Adler AJ
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-5825 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 UTC 2011
Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.
PloS one
Almolda B,Costa M,Montoya M,González B,Castellano B
Published figure using T-bet monoclonal antibody (Product # 14-5825-82) in Flow Cytometry
Mon Mar 26 00:00:00 UTC 2012
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
Nature communications
Haabeth OA,Lorvik KB,Hammarström C,Donaldson IM,Haraldsen G,Bogen B,Corthay A
14-5825 was used in Flow cytometry/Cell sorting to investigate the nature of protective anti-tumour immunity.
Mon Aug 01 00:00:00 UTC 2011
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
The Journal of experimental medicine
Xie Y,Akpinarli A,Maris C,Hipkiss EL,Lane M,Kwon EK,Muranski P,Restifo NP,Antony PA
14-5825 was used in Flow cytometry/Cell sorting to study the regression of tumours due to naive tumor-specific CD4(+) T cell differentiation.
Mon Mar 15 00:00:00 UTC 2010
Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ness-Schwickerath KJ,Jin C,Morita CT
Tue Jun 15 00:00:00 UTC 2010
Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa.
Blood
Imanguli MM,Swaim WD,League SC,Gress RE,Pavletic SZ,Hakim FT
14-5825 was used in Immunofluorescence to support the model that oral cGVHD results from type I IFN-driven immigration, proliferation, and differentiation of T-bet(+) type I T effectors.
Thu Apr 09 00:00:00 UTC 2009
