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Invitrogen
TAF6 Polyclonal Antibody
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Product Details
PA5-41502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human TAF6 (aa 576-625).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608650
Product Specific Information
Peptide sequence: PSVQPIVKLV STATTAPPST APSGPGSVQK YIVVSLPPTG EGKGGPTSHP
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Target Information
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781E21155; RNA polymerase II TBP-associated factor subunit E; TAF(II)70; TAF(II)80; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; TATA box binding protein associated factor 6; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; Transcription initiation factor TFIID subunit 6
Gene Aliases: MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAF6; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85
UniProt ID: (Human) P49848
Entrez Gene ID: (Human) 6878
DNA-templated transcription, initiation
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
snRNA transcription from RNA polymerase II promoter
negative regulation of cell cycle
regulation of sequence-specific DNA binding transcription factor activity
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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