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TAFA5 Antibody (PA5-47702) in WB
Western blot analysis of TAFA5 in bEnd.3 mouse endothelioma cell line, T98G human glioblastoma cell line, Neuro‚2A mouse neuroblastoma cell line, and IMR‚32 human neuroblastoma cell line. Samples were incubated in TAFA5 polyclonal antibody (Product # PA5-47702) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for TAFA5/FAM19A5 at approximately 21 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47702
Product Specifications
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human TAFA5/FAM19A5 Gln26-Ser125
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607054
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) TAFA1, rhTAFA2, rhTAFA3, and rhTAFA4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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