Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
TAFII p135/p105 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-36243
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 951-1000 of human TAF II p135
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553435
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 135 kDa and 105 kDa.
Purity is >95% by SDS-PAGE.
Target Information
TAF II p105, also called TAF4B, is a celltype specific transcriptional co-activator that is a component of the TFIID complex. Expressed primarily in B cells and ovarian granulosa cells, TAF II p105 can interact with OCBA/POU2AF1 to activate B cell-specific octamerdependent transcription. Additionally, TAF II p105 plays an important role in co-activating the transcription factor NFkB and is essential for activation of anti-apoptotic genes such as TNFAIP3. TAF II p135, also known as TAF4, TAF2C, TAF2C1, TAF4A or TAFII130, is a 1,085 amino acid subunit of TFIID that accelerates transcriptional activation triggered by thyroid hormone (TR) or retinoic acid (RA). Localized to the nucleus, TAF II p135 contains one TAFH domain and is thought to bind to proteins that contain glutamine-rich domains, such as the transcription factor CREB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: RNA polymerase II TBP-associated factor subunit C; similar to Transcription initiation factor TFIID 105 kDa subunit (TAFII-105); TAF(II)105; TAF(II)130; TAF(II)135; TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD; TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; TAFII 130; TAFII 135; TAFII-130; TAFII-135; TATA box binding protein (TBP)-associated factor 4B; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; TATA box binding protein associated factor 4; TATA box binding protein associated factor 4b; TBP-associated factor 4; Transcription initiation factor TFIID 105 kDa subunit; Transcription initiation factor TFIID 130 kDa subunit; transcription initiation factor TFIID 135 kD subunit; Transcription initiation factor TFIID 135 kDa subunit; Transcription initiation factor TFIID subunit 4; Transcription initiation factor TFIID subunit 4B
Gene Aliases: 105kDa; 135kDa; 2610524B04Rik; 4932409F03Rik; AI450312; AW987595; SPGF13; TAF2C; TAF2C1; TAF2C2; TAF4; TAF4A; TAF4B; TAFII-105; TAFII105; TAFII130; TAFII135
UniProt ID: (Human) O00268, (Human) Q92750, (Mouse) G5E8Z2
Entrez Gene ID: (Rat) 291773, (Human) 6874, (Human) 6875, (Rat) 682097, (Mouse) 228980, (Mouse) 72504
transcription, DNA-templated
DNA-templated transcription, initiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
spermatogenesis
cell differentiation
oogenesis
ovarian follicle development
transcription initiation from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
transcription elongation from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support