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Product Details
24421-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TALPID3 Fusion Protein Ag19813 (1201-1533 aa encoded by BC066647)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SQMPGSDSS TLESTLSVTV TETETLDKPI SEGEILFSCG QKLAPKILED IGLYLTNLND SLSSTLHDAV EMEDDPPSEG QVIRMSHKKF HADAILSFAK QNQESAVSQQ AVYHSEDLEN SVGELSEGQR PQLTAAAENI LMGHSLYMQP PVTNTQSLDQ QCDPKPLSRQ FDTVSGSIYE DSCASHGPMS LGELELEPNS KLVLPTTLLT AQENDVNLPV AAEDFSQYQL KQNQDVKQVE HKPSQSYLRV RNKSDIAPSQ QQVSPGDMDR TQIELNPYLT CVFSGGKAVP LSASQMPPAK MSVMLPSVNL EDCSQSLSLS TMQEDMESSG ADTF (1201-1533 aa encoded by BC066647)
Target Information
KIAA0586 also named as Talpid3 is a 1472 amino-acid protein, which belongs to Talpid3 family. Talpid3 is a gene essential for vertebrate development. Studies in chicken, mouse, zebrafish and human have shown that TALPID3 is a centrosomal protein, mutants null for TALPID3 fail to produce cilia, resulting in far reaching signaling defects such as polydactyly, dorsalised neural tube, craniofacial and vascular defects often due to abnormalities in Hedgehog signal transduction. Talpid3 is absolutely required for the function of both Gli repressor and activator in the intracellular Hedgehog pathway and ciliogenesis. TALPID3 may be identified as a subcellular maker of centrosome and needed to further studied.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ortholog of chicken talpid{3}; Protein TALPID3
Gene Aliases: JBTS23; KIAA0586; SRTD14; TALPID3
UniProt ID: (Human) Q9BVV6
Entrez Gene ID: (Dog) 480340, (Human) 9786
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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