Proteintech

TAOK2 Polyclonal Antibody

TAOK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

TAOK2 Antibody (21188-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 21188-1-AP) (TAOK2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

TAOK2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21188-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

Assay-dependent

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TAOK2 Fusion Protein Ag15521 (742-969 aa encoded by BC142663)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The immunogen of this antibody is 742-969 aa of human TAOK2 protein isoform Alpha. This antibody mainly detects the isoforms 1, 3, and 4. It does not detect isoform 2.

Immunogen sequence: SLKVRAGQR PPGLPLPIPG ALGPPNTGTP IEQQPCSPGQ EAVLDQRMLG EEEEAVGERR ILGKEGATLE PKQQRILGEE SGAPSPSPQK HGSLVDEEVW GLPEEIEELR VPSLVPQERS IVGQEEAGTW SLWGKEDESL LDEEFELGWV QGPALTPVPE EEEEEEEGAP IGTPRDPGDG CPSPDIPPEP PPTHLRPCPA SQLPGLLSHG LLAGLSFAVG SSSGLLPLL (742-969 aa encoded by BC142663)

Target Information

TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning.

Journal of cell science

Garg R,Koo CY,Infante E,Giacomini C,Ridley AJ,Morris JDH

Mon Mar 16 00:00:00 UTC 2020

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.

American journal of human genetics

Burns DT,Donkervoort S,Müller JS,Knierim E,Bharucha-Goebel D,Faqeih EA,Bell SK,AlFaifi AY,Monies D,Millan F,Retterer K,Dyack S,MacKay S,Morales-Gonzalez S,Giunta M,Munro B,Hudson G,Scavina M,Baker L,Massini TC,Lek M,Hu Y,Ezzo D,AlKuraya FS,Kang PB,Griffin H,Foley AR,Schuelke M,Horvath R,Bönnemann CG

Thu May 03 00:00:00 UTC 2018

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.

American journal of human genetics

Thu May 03 00:00:00 UTC 2018

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.

American journal of human genetics

Thu May 03 00:00:00 UTC 2018

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.

American journal of human genetics

Thu May 03 00:00:00 UTC 2018

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

Acta neuropathologica communications

Giacomini C,Koo CY,Yankova N,Tavares IA,Wray S,Noble W,Hanger DP,Morris JDH

Mon May 07 00:00:00 UTC 2018

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

Acta neuropathologica communications

Giacomini C,Koo CY,Yankova N,Tavares IA,Wray S,Noble W,Hanger DP,Morris JDH

Mon May 07 00:00:00 UTC 2018

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

Acta neuropathologica communications

Giacomini C,Koo CY,Yankova N,Tavares IA,Wray S,Noble W,Hanger DP,Morris JDH

Mon May 07 00:00:00 UTC 2018

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

Acta neuropathologica communications

Giacomini C,Koo CY,Yankova N,Tavares IA,Wray S,Noble W,Hanger DP,Morris JDH

Mon May 07 00:00:00 UTC 2018

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

Molecular cancer therapeutics

Koo CY,Giacomini C,Reyes-Corral M,Olmos Y,Tavares IA,Marson CM,Linardopoulos S,Tutt AN,Morris JDH

Wed Nov 01 00:00:00 UTC 2017

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

Molecular cancer therapeutics

Koo CY,Giacomini C,Reyes-Corral M,Olmos Y,Tavares IA,Marson CM,Linardopoulos S,Tutt AN,Morris JDH

Wed Nov 01 00:00:00 UTC 2017

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

Molecular cancer therapeutics

Koo CY,Giacomini C,Reyes-Corral M,Olmos Y,Tavares IA,Marson CM,Linardopoulos S,Tutt AN,Morris JDH

Wed Nov 01 00:00:00 UTC 2017

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

Molecular cancer therapeutics

Koo CY,Giacomini C,Reyes-Corral M,Olmos Y,Tavares IA,Marson CM,Linardopoulos S,Tutt AN,Morris JDH

Wed Nov 01 00:00:00 UTC 2017

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.

The Journal of biological chemistry

Tavares IA,Touma D,Lynham S,Troakes C,Schober M,Causevic M,Garg R,Noble W,Killick R,Bodi I,Hanger DP,Morris JD

Fri May 24 00:00:00 UTC 2013

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.

The Journal of biological chemistry

Tavares IA,Touma D,Lynham S,Troakes C,Schober M,Causevic M,Garg R,Noble W,Killick R,Bodi I,Hanger DP,Morris JD

Fri May 24 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; serine-threonine kinase; serine/threonine protein kinase TAO2; Serine/threonine-protein kinase TAO2; tao; TAO kinase 2TAO kinase 2; Thousand and one amino acid protein 2; Thousand and one amino acid protein kinase 2

View more View less

Gene Aliases: 1110033K02Rik; B230344N16; KIAA0881; MAP3K17; mKIAA0881; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431

View more View less

UniProt ID: (Human) Q9UL54, (Mouse) Q6ZQ29, (Rat) Q9JLS3

View more View less

Entrez Gene ID: (Human) 9344, (Mouse) 381921, (Rat) 64666

View more View less

Function(s)

protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity ATP binding mitogen-activated protein kinase kinase binding nucleotide binding protein kinase activity MAP kinase kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

MAPK cascade activation of MAPKK activity protein phosphorylation response to stress cellular response to DNA damage stimulus regulation of mitotic cell cycle regulation of cell shape phosphorylation signal transduction by protein phosphorylation actin cytoskeleton organization stress-activated protein kinase signaling cascade G2 DNA damage checkpoint positive regulation of stress-activated MAPK cascade regulation of apoptotic process positive regulation of JNK cascade focal adhesion assembly stress-activated MAPK cascade regulation of cell growth protein targeting to membrane apoptotic process cell migration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TAOK2 Polyclonal Antibody

TAOK2 Antibody (21188-1-AP) in IHC (P)

Product Details

21188-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!