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Product Details
PA5-67854
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human TAOK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2692232
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; serine-threonine kinase; serine/threonine protein kinase TAO2; Serine/threonine-protein kinase TAO2; tao; TAO kinase 2TAO kinase 2; Thousand and one amino acid protein 2; Thousand and one amino acid protein kinase 2
Gene Aliases: 1110033K02Rik; B230344N16; KIAA0881; MAP3K17; mKIAA0881; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54, (Mouse) Q6ZQ29, (Rat) Q9JLS3
Entrez Gene ID: (Human) 9344, (Mouse) 381921, (Rat) 64666
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
mitogen-activated protein kinase kinase binding
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
activation of MAPKK activity
protein phosphorylation
response to stress
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
regulation of cell shape
phosphorylation
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
regulation of apoptotic process
positive regulation of JNK cascade
focal adhesion assembly
stress-activated MAPK cascade
regulation of cell growth
protein targeting to membrane
apoptotic process
cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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