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Proteintech
TAP1 Polyclonal Antibody
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Product Details
11114-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TAP1 Fusion Protein Ag1619 (509-808 aa encoded by BC014081)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Western blot analysis using this antibody detected a major band around 70-80kD in HeLa cells.
Immunogen sequence: LYQMQFTQA VEVLLSIYPR VQKAVGSSEK IFEYLDRTPR CPPSGLLTPL HLEGLVQFQD VSFAYPNRPD VLVLQGLTFT LRPGEVTALV GPNGSGKSTV AALLQNLYQP TGGQLLLDGK PLPQYEHRYL HRQVAAVGQE PQVFGRSLQE NIAYGLTQKP TMEEITAAAV KSGAHSFISG LPQGYDTEVD EAGSQLSGGQ RQAVALARAL IRKPCVLILD DATSALDANS QLQVEQLLYE SPERYSRSVL LITQHLSLVE QADHILFLEG GAIREGGTHQ QLMEKKGCYW AMVQAPADAP E (509-808 aa encoded by BC014081)
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC transporter, MHC 1; ABC transporter, MHC, 1; ABP-278; ABP-280; ABP-280 homolog; Antigen peptide transporter 1; AOI; APT1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500; FLN-B; FLN1L; Histocompatibility antigen modifier 1; LRS1; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; Really interesting new gene 4 protein; RING4; SCT; TABP; tap i; thyroid autoantigen; transporter 1 ATP-binding cassette sub-family B; transporter 1, ABC (ATP binding cassette); transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1
Gene Aliases: ABC17; ABCB2; APT1; D6S114E; Ham-1; Ham1; MTP1; PSF-1; PSF1; RING4; TAP; Tap-1; TAP1; TAP1*0102N; TAP1N; Y3
UniProt ID: (Human) Q03518, (Mouse) P21958
Entrez Gene ID: (Human) 6890, (Mouse) 21354
protein binding
ATP binding
peptide transporter activity
peptide-transporting ATPase activity
MHC class Ib protein binding
MHC class I protein binding
peptide antigen binding
ATPase activity, coupled to transmembrane movement of substances
protein homodimerization activity
ADP binding
TAP1 binding
TAP2 binding
tapasin binding
protein heterodimerization activity
nucleotide binding
ATPase activity
MHC protein binding
immune system process
transport
defense response
metabolic process
protein transport
peptide transport
intracellular transport of viral protein in host cell
antigen processing and presentation of endogenous peptide antigen via MHC class I
protection from natural killer cell mediated cytotoxicity
cytosol to ER transport
transmembrane transport
adaptive immune response
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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