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Proteintech
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Immunogen sequence: EATDSRTPE VPAGEGPRRG LGAPLTEDQQ NRLSEEIEKK WQELEKLPLR ENKRVPLTAL LNQSRGERRG PPSDGHEALE KEVQALRAQL EAWRLQGEAP QSALRSQEDG HIPPGYISQE ACERSLAEME SSHQQVMEEL QRHHERELQR LQQEKEWLLA EETAATASAI EAMKKAYQEE LSRELSKTRS LQQGPDGLRK QHQSDVEALK RELQVLSEQY SQKCLEIGAL MRQAEEREHT LRRCQQEGQE LLRHNQELHG RLSEEIDQLR GFIASQGMGN GCGRSNERSS CELEVLLRVK ENELQYLKKE VQCLRDELQM MQKDKRFTSG KYQDVYVELS HIKTRSEREI EQLKEHLRLA MAALQEKESM RNSLAE (5-379 aa encoded by B C013278)
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Protein Tara; tara-like protein; TRF1-associated protein of 68 kDa; TRIO and F-actin-binding protein; Trio-associated repeat on actin
Gene Aliases: DFNB28; dJ37E16.4; HRIHFB2122; KIAA1662; TAP68; TARA; TRIOBP
UniProt ID: (Human) Q9H2D6
Entrez Gene ID: (Human) 11078
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