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Invitrogen
TARC Recombinant Rabbit Monoclonal Antibody (B22H33L5)
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FIGURE: 1 / 3
TARC Antibody (700655) in IHC (P)
Immunohistochemistry analysis of TARC showing weak staining in the cytoplasm paraffin-embedded mouse spleen tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, w... View More
Product Details
700655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
B22H33L5
Immunogen
A portion of recombinant human TARC protein corresponding to amino acids 24-94
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2532335
Product Specific Information
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
TARC ligand (CCL17) belongs to the CC chemokine family. It is a small cytokine and the gene is located on q arm of chromosome 16, in humans, along with other chemokines. TARC specifically binds to T-cells and interacts with chemokine receptors CCR4 and CCR8. It plays an important role in T cell development in thymus as well as in trafficking and activation of mature T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABCD-2; C-C motif chemokine; C-C motif chemokine 17; CC chemokine TARC; chemokine (C-C motif) ligand 17; small inducible cytokine subfamily A (Cys-Cys), member 17; small inducible cytokine subfamily A17; Small-inducible cytokine A17; T cell-directed CC chemokine; Thymus and activation-regulated chemokine
Gene Aliases: A-152E5.3; ABCD-2; CCL17; SCYA17; Scya17l; TARC
UniProt ID: (Human) Q92583, (Mouse) Q9WUZ6
Entrez Gene ID: (Human) 6361, (Mouse) 20295
chemotaxis
cellular defense response
signal transduction
negative regulation of myoblast differentiation
cell chemotaxis
monocyte chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
cell-cell signaling
multicellular organism development
neutrophil chemotaxis
positive regulation of GTPase activity
lymphocyte chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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