Proteintech

TARS2 Polyclonal Antibody

TARS2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

TARS2 Antibody (15067-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 15067-1-AP (TARS2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TARS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TARS2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15067-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TARS2 Fusion Protein Ag7074 (369-718 aa encoded by BC000541)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EHYQEDMFA VQPPGSDRPP SSQSDDSTRH ITDTLALKPM NCPAHCLMFA HRPRSWRELP LRLADFGALH RAEASGGLGG LTRLRCFQQD DAHIFCTTDQ LEAEIQSCLD FLRSVYAVLG FSFRLALSTR PSGFLGDPCL WDQAEQVLKQ ALKEFGEPWD LNSGDGAFYG PKIDVHLHDA LGRPHQCGTI QLDFQLPLRF DLQYKGQAGA LERPVLIHRA VLGSVERLLG VLAESCGGKW PLWLSPFQVV VIPVGSEQEE YAKEAQQSLR AAGLVSDLDA DSGLTLSRRI RRAQLAHYNF QFVVGQKEQS KRTVNIRTRD NRRLGEWDLP EAVQRLVELQ NTRVPNAEEI F (369-718 aa encoded by BC000541)

Target Information

This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle.

Redox biology

López-Soldado I,Torres AG,Ventura R,Martínez-Ruiz I,Díaz-Ramos A,Planet E,Cooper D,Pazderska A,Wanic K,O'Hanlon D,O'Gorman DJ,Carbonell T,Ribas de Pouplana L,Nolan JJ,Zorzano A,Hernández-Alvarez MI

Mon May 01 00:00:00 UTC 2023

Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.

Bioengineered

Tian H,Yan H,Zhang Y,Fu Q,Li C,He J,Li H,Zhou Y,Huang Y,Li R

Tue Mar 01 00:00:00 UTC 2022

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 UTC 2021

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 UTC 2021

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Threonine--tRNA ligase, mitochondrial; Threonyl-tRNA synthetase; threonyl-tRNA synthetase, mitochondrial; Threonyl-tRNA synthetase-like 1; ThrRS

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Gene Aliases: 2610024N01Rik; AI429208; COXPD21; RGD1308283; TARS2; TARSL1; thrRS

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UniProt ID: (Human) Q9BW92, (Mouse) Q3UQ84, (Rat) Q68FW7

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Entrez Gene ID: (Human) 80222, (Mouse) 71807, (Rat) 310672

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Function(s)

molecular_function RNA binding threonine-tRNA ligase activity ATP binding nucleotide binding aminoacyl-tRNA ligase activity ligase activity ligase activity, forming aminoacyl-tRNA and related compounds

Process(es)

translation tRNA aminoacylation for protein translation threonyl-tRNA aminoacylation tRNA aminoacylation mitochondrial threonyl-tRNA aminoacylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TARS2 Polyclonal Antibody

TARS2 Antibody (15067-1-AP) in ICC/IF

Product Details

15067-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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