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TAS2R38 Antibody (PA5-90212) in WB
Western blot analysis of TAS2R38 in extracts of Rat thymus. Samples were incubated with TAS2R38 Polyclonal antibody (Product # PA5-90212) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-90212
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_7897874)
Conjugate
Form
Liquid
Concentration
0.87 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805962
Product Specific Information
Immunogen sequence: CSCICTVLCV WCFFSRPHFT VTTVLFMNNN TRLNWQIKDL NLFYSFLFCY LWSVPPFLLF LVSSGMLTVS LGRHMRTMKV YTRNSRDPSL EAHIKALKSL V; Positive Samples: rat thymus; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting); also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T2R26; T2R38; T2r38 {ECO:0000312|RGD:1560649}; Taste receptor type 2 member 138; Taste receptor type 2 member 26; Taste receptor type 2 member 38; taste receptor, type 2, member 38
Gene Aliases: T2R38; Tas2r138; Tas2r26; Tas2r38
UniProt ID: (Rat) Q4VHE7
Entrez Gene ID: (Rat) 500091
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