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Immunogen sequence: MTMEKGMSS GEGLPSRSSQ VSAGKITAKE LETKQSYKEK RGGFVLVHAG AGYHSESKAK EYKHVCKRAC QKAIEKLQAG ALATDAVTAA LVELEDSPFT NAGMGSNLNL LGEIECDASI MDGKSLNFGA VGALSGIKNP VSVANRLLCE GQKGKLSAGR IPPCFLVGEG AYRWAVDHGI PSCPPNIMTT RFSLAAFKRN KRKLELAERV DTDFMQLKKR RQSSEKENDS GTLDTVGAVV VDHEGNVAAA VSSGGLALKH PGRVGQAALY GCGCWAENTG AHNPYSTAVS TSGCGEHLVR TILARECSHA LQAEDAHQAL LETMQNKFIS SPFLASEDGV LGGVIVLRSC RCSAEPDSSQ NKQTLLVEFL WSHTTESMCV GYMSAQDGKA KTHISRLPPG AVAGQSVAIE GGVCRLESPV N (1-420 aa encoded by BC025266)
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ20212; MGC39159; taspase 1; Taspase-1; Threonine aspartase 1
Gene Aliases: 4930485D02Rik; AW986064; C20orf13; dJ585I14.2; RGD1308591; TASP1
UniProt ID: (Human) Q9H6P5, (Mouse) Q8R1G1
Entrez Gene ID: (Human) 55617, (Rat) 311468, (Mouse) 75812
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