Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Peptide sequence: QNKQTLLVEF LWSHTTESMC VGYMSAQDGK AKTHISRLPP GAVAGQSVAI
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ20212; MGC39159; Taspase-1; Threonine aspartase 1
Gene Aliases: C20orf13; dJ585I14.2; TASP1
UniProt ID: (Human) Q9H6P5
Entrez Gene ID: (Human) 55617
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