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Invitrogen
TATDN3 Polyclonal Antibody
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Product Details
PA5-28490
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TATDN3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545966
Product Specific Information
Recommended positive controls: NT2D1, SK-N-SH, mouse testis.
Predicted reactivity: Mouse (86%), Rat (87%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The TATDN3 gene encodes the protein TatD DNase domain containing 3, which belongs to a family of nucleases with a range of enzymatic activities. TATDN3 is known to exhibit apurinic/apyrimidinic (AP) endonuclease activity, which is crucial for DNA repair mechanisms, particularly in the recognition and removal of damaged bases. Structurally, the TatD family proteins, including TATDN3, possess a conserved nuclease domain that enables their function in DNA metabolism. Studies demonstrate that TATDN3 can also display 3'-5' exonuclease activity, further contributing to genome stability by processing DNA ends. Phylogenetically, TATDN3 represents a distinct clade with unique active site motifs, differentiating it from other paralogs such as TATDN1. Given its involvement in critical cellular processes, TATDN3 is an important factor in maintaining genomic integrity and preventing mutations that may lead to diseases such as cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Putative deoxyribonuclease TATDN3
Gene Aliases: 1500010M24Rik; TATDN3
UniProt ID: (Human) Q17R31, (Mouse) Q3U1C6
Entrez Gene ID: (Human) 128387, (Mouse) 68972
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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