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Proteintech
TBC1D17 Polyclonal Antibody
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Product Details
20482-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBC1D17 Fusion Protein Ag14358 (1-350 aa encoded by BC003516)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEGAGYRVV FEKGGVYLHT SAKKYQDRDS LIAGVIRVVE KDNDVLLHWA PVEEAGDSTQ ILFSKKDSSG GDSCASEEEP TFDPGYEPDW AVISTVRPQP CHSEPTRGAE PSCPQGSWAF SVSLGELKSI RRSKPGLSWA YLVLVTQAGG SLPALHFHRG GTRALLRVLS RYLLLASSPQ DSRLYLVFPH DSSALSNSFH HLQLFDQDSS NVVSRFLQDP YSTTFSSFSR VTNFFRGALQ PQPEGAASDL PPPPDDEPEP GFEVISCVEL GPRPTVERGP PVTEEEWARH VGPEGRLQQV PELKNRIFSG GLSPSLRREA WKFLLGYLSW EGTAEEHKAH IRKKTDEYFR M (1-350 aa encoded by BC003516)
Target Information
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TBC1 domain family member 17; TBC1 domain family, member 17
Gene Aliases: BC017607; TBC1D17
UniProt ID: (Human) Q9HA65, (Mouse) Q8BYH7
Entrez Gene ID: (Human) 79735, (Mouse) 233204
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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