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Proteintech
TBC1D22A Polyclonal Antibody
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Product Details
18332-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBC1D22A Fusion Protein Ag12942 (1-517 aa encoded by BC001292)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASDGARKQ FWKRSNSKLP GSIQHVYGAQ HPPFDPLLHG TLLRSTAKMP TTPVKAKRVS TFQEFESNTS DAWDAGEDDD ELLAMAAESL NSKVVMETAN RVLRNHSQRQ GRPTLQEGPG LQQKPRPEAE PPSPPSGDLR LVKSVSESHT SCPAESASDA APLQRSQSLP HSATVTLGGT SDPSTLSSSA LSEREASRLD KFKQLLAGPN TDLEELRRLS WSGIPKPVRP MTWKLLSGYL PANVDRRPAT LQRKQKEYFA FIEHYYDSRN DEVHQDTYRQ IHIDIPRMSP EALILQPKVT EIFERILFIW AIRHPASGYV QGINDLVTPF FVVFICEYIE AEEVDTVDVS CVPAEVLCNI EADTYWCMSK LLDGIQDNYT FAQPGIQMKV KMLEELVSRI DEQVHRHLDQ HEVRYLQFAF RWMNNLLMRE VPLRCTIRLW DTYQSEPDGF SHFHLYVCAA FLVRWRKEIL EEKDFQELLL FLQNLPTAHW DDEDISLLLA EAYRLKFAFA DAPNHYKK (1-517 aa encoded by BC001292)
Target Information
TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: putative GTPase activator; TBC1 domain family member 22A; TBC1 domain family, member 22A
Gene Aliases: BC023106; C22orf4; D15Ertd781e; HSC79E021; RGD1306588; TBC1D22A
UniProt ID: (Human) Q8WUA7, (Mouse) Q8R5A6
Entrez Gene ID: (Human) 25771, (Rat) 689443, (Mouse) 223754
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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